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  1. Unlike infections with mycobacteria, reports of unusual viral infections in interferon-gamma-receptor (IFNγR) deficient patients are scarce. Therefore, discussion about increased susceptibility to viral infect...

    Authors: Julia Körholz, Nicole Richter, Jochen Schäfer, Catharina Schuetz and Joachim Roesler

    Citation: Molecular and Cellular Pediatrics 2020 7:14

    Content type: Case Report

    Published on:

  2. Glomerulonephritis results in a dysregulation of glomerular cells and may end up in chronic alterations and subsequent loss of renal function. Therefore, understanding mechanisms, which contribute to maintain ...

    Authors: Ines Marek, Karl Friedrich Hilgers, Wolfgang Rascher, Joachim Woelfle and Andrea Hartner

    Citation: Molecular and Cellular Pediatrics 2020 7:13

    Content type: Mini review

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  3. Linear bone growth is achieved by the division of chondrocytes at the growth plate and is regulated by endocrine and paracrine factors such as growth hormone. Mutations that negatively affect chondrogenesis ca...

    Authors: Nami Mohammadian Khonsari, Sahar Mohammad Poor Nami, Benyamin Hakak-Zargar and Tessa Voth

    Citation: Molecular and Cellular Pediatrics 2020 7:11

    Content type: Case Study

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  4. Long-term outcomes of hematopoietic stem cell transplantation (HSCT) in children with juvenile metachromatic leukodystrophy (MLD) have been investigated systematically, while short-term effects of HSCT on the ...

    Authors: Judith Beschle, Michaela Döring, Christiane Kehrer, Christa Raabe, Ute Bayha, Manuel Strölin, Judith Böhringer, Andrea Bevot, Nadja Kaiser, Benjamin Bender, Alexander Grimm, Peter Lang, Ingo Müller, Ingeborg Krägeloh-Mann and Samuel Groeschel

    Citation: Molecular and Cellular Pediatrics 2020 7:12

    Content type: Research

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  5. Hyperoxia is a well-known cause of cerebral white matter injury in preterm infants with male sex being an independent and critical risk factor for poor neurodevelopmental outcome. Sex is therefore being widely...

    Authors: Donna Elizabeth Sunny, Elke Hammer, Sebastian Strempel, Christy Joseph, Himanshu Manchanda, Till Ittermann, Stephanie Hübner, Frank Ulrich Weiss, Uwe Völker and Matthias Heckmann

    Citation: Molecular and Cellular Pediatrics 2020 7:10

    Content type: Research

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  6. Osteogenesis imperfecta (OI) is a rare congenital disease with a wide spectrum of severity characterized by skeletal deformity and increased bone fragility as well as additional, variable extraskeletal symptom...

    Authors: Julia Etich, Lennart Leßmeier, Mirko Rehberg, Helge Sill, Frank Zaucke, Christian Netzer and Oliver Semler

    Citation: Molecular and Cellular Pediatrics 2020 7:9

    Content type: Mini review

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  7. Nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency is caused by mutations in the active 21-hydroxylase gene (CYP21A2). The clinical symptoms can vary greatly. To date, no systematic s...

    Authors: Helmuth-Günther Dörr, Nadja Schulze, Markus Bettendorf, Gerhard Binder, Walter Bonfig, Christian Denzer, Desiree Dunstheimer, Kirsten Salzgeber, Heinrich Schmidt, Karl Otfried Schwab, Egbert Voss, Martin Wabitsch and Joachim Wölfle

    Citation: Molecular and Cellular Pediatrics 2020 7:8

    Content type: Research

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  8. Biomarkers which predict future health outcomes are key to the goals of precision health. Such biomarkers do not have to be involved in the causal pathway of a disease, and their performance is best assessed u...

    Authors: Shivanthan Shanthikumar, Melanie R. Neeland, Jovana Maksimovic, Sarath C. Ranganathan and Richard Saffery

    Citation: Molecular and Cellular Pediatrics 2020 7:7

    Content type: Review

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  9. The postnatal intestinal colonization of human milk-fed and formula-fed infants differs substantially, as does the susceptibility to infectious diseases during infancy. Specific ingredients in human milk, such...

    Authors: Antonia Nomayo, Andreas Schwiertz, Rainer Rossi, Katharina Timme, Janine Foster, Richard Zelenka, Josef Tvrdik and Frank Jochum

    Citation: Molecular and Cellular Pediatrics 2020 7:6

    Content type: Research

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  10. Febrile neutropenia is a common and serious complication during treatment of childhood cancer. Empirical broad-spectrum antibiotics are usually administered until neutrophil cell count recovery. It was the aim...

    Authors: Mira Siegmund, Julia Pagel, Tasja Scholz, Jan Rupp, Christoph Härtel and Melchior Lauten

    Citation: Molecular and Cellular Pediatrics 2020 7:5

    Content type: Research

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  11. To ascertain interactions of caffeine ingestion, food, medications, and environmental exposures during preterm human gestation, under informed consent, we studied a cohort of Mexican women with further preterm...

    Authors: M. R. Alcorta-García, C. N. López-Villaseñor, G. Sánchez-Ferrer, H. Flores-Mendoza, F. Castorena-Torres, M. A. Aguilar-Torres, C. M. Sepúlveda-Treviño, J. A. Hernández-Hernández, R. C. López-Sánchez and V. J. Lara-Díaz

    Citation: Molecular and Cellular Pediatrics 2020 7:4

    Content type: Research

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  12. Optoacoustic imaging (OAI), or photoacoustic imaging (PAI), has fundamentally influenced basic science by providing high-resolution visualization of biological mechanisms. With the introduction of multispectra...

    Authors: Adrian P. Regensburger, Alexandra L. Wagner, Jing Claussen, Maximilian J. Waldner and Ferdinand Knieling

    Citation: Molecular and Cellular Pediatrics 2020 7:3

    Content type: Mini review

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  13. X chromosome inactivation (XCI) is an indispensable process in the development of human female embryos. Reportedly, XCI occurs when a blastocyst contains 10–12 embryonic progenitor cells. To date, it remains u...

    Authors: Kenichi Kinjo, Tomoko Yoshida, Yoshitomo Kobori, Hiroshi Okada, Erina Suzuki, Tsutomu Ogata, Mami Miyado and Maki Fukami

    Citation: Molecular and Cellular Pediatrics 2020 7:1

    Content type: Short Communication

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  14. The impairment of nephrogenesis is caused by noxae, all of which are significantly different in molecular composition. These can cause an early termination of nephron development in preterm and low birth weigh...

    Authors: Will W. Minuth

    Citation: Molecular and Cellular Pediatrics 2020 7:2

    Content type: Research

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  15. In Western countries, vegetarian diets are associated with lower intakes of energy, saturated fatty acids and animal protein and higher intakes of fibre and phytochemicals, compared to omnivorous diets. Whethe...

    Authors: Silvia Rudloff, Christoph Bührer, Frank Jochum, Thomas Kauth, Mathilde Kersting, Antje Körner, Berthold Koletzko, Walter Mihatsch, Christine Prell, Thomas Reinehr and Klaus-Peter Zimmer

    Citation: Molecular and Cellular Pediatrics 2019 6:4

    Content type: Consensus Paper

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  16. Low vitamin D serum concentrations have been associated with rickets and other disorders in observational studies. Since vitamin D serum concentrations in children and adolescents are frequently below referenc...

    Authors: Thomas Reinehr, Dirk Schnabel, Martin Wabitsch, Susanne Bechtold-Dalla Pozza, Christoph Bührer, Bettina Heidtmann, Frank Jochum, Thomas Kauth, Antje Körner, Walter Mihatsch, Christine Prell, Silvia Rudloff, Bettina Tittel, Joachim Woelfle, Klaus-Peter Zimmer and Berthold Koletzko

    Citation: Molecular and Cellular Pediatrics 2019 6:3

    Content type: Consensus Paper

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  17. Pureed complementary feeding products packed in squeezable plastic pouches, usually with a spout and a screw cap, have been increasingly marketed. The Committee on Nutrition recommends that infants and young c...

    Authors: Berthold Koletzko, Christoph Bührer, Regina Ensenauer, Frank Jochum, Hermann Kalhoff, Burkhard Lawrenz, Antje Körner, Walter Mihatsch, Silvia Rudloff and Klaus-Peter Zimmer

    Citation: Molecular and Cellular Pediatrics 2019 6:2

    Content type: Consensus Paper

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  18. Birth cohort studies can contribute substantially to the understanding of health and disease — in childhood and over the life course. The KUNO-Kids birth cohort study was established to investigate various asp...

    Authors: Susanne Brandstetter, Antoaneta A. Toncheva, Jakob Niggel, Christine Wolff, Silvia Gran, Birgit Seelbach-Göbel, Christian Apfelbacher, Michael Melter and Michael Kabesch

    Citation: Molecular and Cellular Pediatrics 2019 6:1

    Content type: Research

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  19. β-Thalassemia is an inherited hematological disorder caused by mutations in the human hemoglobin beta (HBB) gene that reduce or abrogate β-globin expression. Although lentiviral-mediated expression of β-globin an...

    Authors: Justin S. Antony, Ngadhnjim Latifi, A. K. M. Ashiqul Haque, Andrés Lamsfus-Calle, Alberto Daniel-Moreno, Sebastian Graeter, Praveen Baskaran, Petra Weinmann, Markus Mezger, Rupert Handgretinger and Michael S. D. Kormann

    Citation: Molecular and Cellular Pediatrics 2018 5:9

    Content type: Short Communication

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  20. Survival rates of children with cancer are steadily increasing. This urges our attention to neurocognitive and psychiatric outcomes, as these can markedly influence the quality of life of these children. Neuro...

    Authors: Chrysanthy Ikonomidou

    Citation: Molecular and Cellular Pediatrics 2018 5:8

    Content type: Mini review

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  21. Outcome in treatment of childhood cancers has improved dramatically since the 1970s. This success was largely achieved by the implementation of cooperative clinical research trial groups that standardized and ...

    Authors: Stefan E. G. Burdach, Mike-Andrew Westhoff, Maximilian Felix Steinhauser and Klaus-Michael Debatin

    Citation: Molecular and Cellular Pediatrics 2018 5:6

    Content type: Review

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  22. Antisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target a...

    Authors: Kelly M. Martinovich, Nicole C. Shaw, Anthony Kicic, André Schultz, Sue Fletcher, Steve D. Wilton and Stephen M. Stick

    Citation: Molecular and Cellular Pediatrics 2018 5:3

    Content type: Review

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  23. Impaired regulatory T cell immunity plays a central role in the development of type 1 diabetes (T1D). Interleukin-2 receptor (IL-2R) signaling is essential for regulatory T cells (TREG), and cytokine-inducible SH...

    Authors: Julia Seyfarth, Heinz Ahlert, Joachim Rosenbauer, Christina Baechle, Michael Roden, Reinhard W. Holl, Ertan Mayatepek, Thomas Meissner and Marc Jacobsen

    Citation: Molecular and Cellular Pediatrics 2018 5:2

    Content type: Research

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  24. Children with inflammatory bowel disease (IBD) or autoimmune hepatitis (AIH) are at risk for severe infections. This is partially a result of their chronic disease condition but, moreover, a side effect of the...

    Authors: Teresa Schleker, Eva-Maria Jacobsen, Benjamin Mayer, Gudrun Strauss, Klaus-Michael Debatin and Carsten Posovszky

    Citation: Molecular and Cellular Pediatrics 2018 5:1

    Content type: Research

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  25. Numerous investigations are dealing with anlage of the mammalian kidney and primary development of nephrons. However, only few information is available about the last steps in kidney development leading at bir...

    Authors: Will W. Minuth

    Citation: Molecular and Cellular Pediatrics 2017 4:12

    Content type: Review

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  26. Mutations in the leptin gene (LEP) can alter the secretion or interaction of leptin with its receptor, leading to extreme early-onset obesity. The purpose of this work was to estimate the prevalence of heteroz...

    Authors: Adriana Nunziata, Guntram Borck, Jan-Bernd Funcke, Katja Kohlsdorf, Stephanie Brandt, Anke Hinney, Barbara Moepps, Peter Gierschik, Klaus-Michael Debatin, Pamela Fischer-Posovszky and Martin Wabitsch

    Citation: Molecular and Cellular Pediatrics 2017 4:10

    Content type: Research

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  27. Transcatheter closure has become the treatment of choice for secundum atrial septal defects (ASD II), but particularly in small children, there is concern regarding procedure-related complications.

    Authors: Roman Scheidmann, Thomas Paul and Matthias Sigler

    Citation: Molecular and Cellular Pediatrics 2017 4:9

    Content type: Case Study

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  28. Autism spectrum disorders (ASDs) are neurodevelopmental disorders with impaired social interactions and communication and restrictive, repetitive patterns of behaviors, interests, and activities. A recent epid...

    Authors: Michaela Kuhlen, Julia Taeubner, Dagmar Wieczorek and Arndt Borkhardt

    Citation: Molecular and Cellular Pediatrics 2017 4:8

    Content type: Short Communication

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  29. Chronic non-bacterial osteomyelitis (CNO) belongs to the growing spectrum of autoinflammatory diseases and primarily affects the skeletal system. Peak onset ranges between 7 and 12 years of age. The clinical s...

    Authors: Sigrun Ruth Hofmann, Franz Kapplusch, Katrin Mäbert and Christian Michael Hedrich

    Citation: Molecular and Cellular Pediatrics 2017 4:7

    Content type: Mini review

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  30. Precursor B acute lymphoblastic leukemia (BCP-ALL), the most common childhood malignancy, arises from an expansion of malignant B cell precursors in the bone marrow. Epidemiological studies suggest that infect...

    Authors: Simone Bürgler and David Nadal

    Citation: Molecular and Cellular Pediatrics 2017 4:6

    Content type: Review

    Published on:

  31. Authors: Rhea van den Bruck, Patrick P. Weil, Thomas Ziegenhals, Philipp Schreiner, Stefan Juranek, Daniel Gödde, Silvia Vogel, Frauke Schuster, Valerie Orth, Johannes Dörner, Daniel Pembaur, Meike Röper, Stefan Störkel, Hubert Zirngibl, Stefan Wirth, Andreas C. W. Jenke…

    Citation: Molecular and Cellular Pediatrics 2017 4(Suppl 1):5

    Content type: Meeting abstracts

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  32. The intrauterine environment was long considered sterile. However, several infectious threats are already present during fetal life. This review focuses on the postnatal immunological consequences of prenatal ...

    Authors: Gijs T. J. van Well, Leonie A. Daalderop, Tim Wolfs and Boris W. Kramer

    Citation: Molecular and Cellular Pediatrics 2017 4:4

    Content type: Review

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  33. Exposure to second-hand tobacco smoke (SHS) is one of the prime risk factors for chronic lung disease development. Smoking during pregnancy may lead to birth defects in the newborn that include pulmonary dysfu...

    Authors: Neel Patel, Christopher D. Trumph, Manish Bodas and Neeraj Vij

    Citation: Molecular and Cellular Pediatrics 2017 4:3

    Content type: Short Communication

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  34. The developmental origin of health and disease concept identifies the brain, cardiovascular, liver, and kidney systems as targets of fetal adverse programming with adult consequences. As the limits of viabilit...

    Authors: Amelie Stritzke, Sumesh Thomas, Harish Amin, Christoph Fusch and Abhay Lodha

    Citation: Molecular and Cellular Pediatrics 2017 4:2

    Content type: Review

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  35. The pathological course of several chronic inflammatory diseases, including cystic fibrosis, chronic obstructive pulmonary disease, and rheumatoid arthritis, features an aberrant innate immune response dominat...

    Authors: Camilla Margaroli and Rabindra Tirouvanziam

    Citation: Molecular and Cellular Pediatrics 2016 3:38

    Content type: Review

    Published on:

  36. Rett syndrome is best known due to its severe and devastating symptoms in the central nervous system. It is produced by mutations affecting the Mecp2 gene that codes for a transcription factor. Nevertheless, evid...

    Authors: Pamela Millar-Büchner, Amber R. Philp, Noemí Gutierrez, Sandra Villanueva, Bredford Kerr and Carlos A. Flores

    Citation: Molecular and Cellular Pediatrics 2016 3:37

    Content type: Research

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  37. Wilms’ tumor is an embryonal neoplasm of the kidney that accounts for approximately 6 % of all childhood tumors. The chemokine CXCL12 (C-X-C chemokine ligand 12) and its ligand CXCR4 (C-X-C chemokine receptor ...

    Authors: Patricia Midori Murobushi Ozawa, Carolina Batista Ariza, Roberta Losi-Guembarovski, Alda Losi Guembarovski, Carlos Eduardo Coral de Oliveira, Bruna Karina Banin-Hirata, Marina Okuyama Kishima, Diego Lima Petenuci and Maria Angelica Ehara Watanabe

    Citation: Molecular and Cellular Pediatrics 2016 3:36

    Content type: Research

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  38. Impaired cellular innate immune defense accounts for susceptibility to sepsis and its high morbidity and mortality in preterm infants. Leukocyte recruitment is an integral part of the cellular immune response ...

    Authors: Katinka Karenberg, Hannes Hudalla and David Frommhold

    Citation: Molecular and Cellular Pediatrics 2016 3:35

    Content type: Mini review

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  39. Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due...

    Authors: Chiharu Ota, Hoeke A. Baarsma, Darcy E. Wagner, Anne Hilgendorff and Melanie Königshoff

    Citation: Molecular and Cellular Pediatrics 2016 3:34

    Content type: Review

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  40. Neonatal leukemia is a rare disease with an estimated prevalence of about one to five in a million neonates. The majority being acute myeloid leukemia (AML), neonatal leukemia can present with a variety of sym...

    Authors: Tobias Gyárfás, Juergen Wintgens, Wolfgang Biskup, Ilske Oschlies, Wolfram Klapper, Reiner Siebert, Susanne Bens, Claudia Haferlach, Roland Meisel, Michaela Kuhlen and Arndt Borkhardt

    Citation: Molecular and Cellular Pediatrics 2016 3:30

    Content type: Short Communication

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  41. Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limited recurrent attacks of fever and serositis. Patients may develop renal amyloidosis. Colchicine prevents attacks ...

    Authors: Betul Sozeri, Nesrin Gulez, Malik Ergin and Erkin Serdaroglu

    Citation: Molecular and Cellular Pediatrics 2016 3:33

    Content type: Case Study

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  42. Asthma is the most common chronic disease starting in childhood and persisting into adulthood in many cases. During childhood, different forms of asthma and wheezing disorders exist that can be discriminated b...

    Authors: Michael Kabesch

    Citation: Molecular and Cellular Pediatrics 2016 3:31

    Content type: Mini review

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  43. Influenza viruses (IVs) circulate seasonally and are a common cause of respiratory infections in pediatric and adult patients. Additionally, recurrent pandemics cause massive morbidity and mortality worldwide....

    Authors: Barbara Rösler and Susanne Herold

    Citation: Molecular and Cellular Pediatrics 2016 3:29

    Content type: Mini review

    Published on: