Articles
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Citation: Molecular and Cellular Pediatrics 2024 11:5
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Changes in vitamins and trace elements after initiation of highly effective CFTR modulator therapy in children and adults with cystic fibrosis – a real-life insight
Highly-effective CFTR-modulator therapy with elexa-/teza-/ivacaftor (ETI) has led to improvements in pulmonary outcomes, sweat chloride, body mass index (BMI) and quality of life in people with cystic fibrosis...
Citation: Molecular and Cellular Pediatrics 2024 11:4 -
Tipping the balance in autoimmunity: are regulatory t cells the cause, the cure, or both?
Regulatory T cells (Tregs) are a specialized subgroup of T-cell lymphocytes that is crucial for maintaining immune homeostasis and preventing excessive immune responses. Depending on their differentiation rout...
Citation: Molecular and Cellular Pediatrics 2024 11:3 -
Adverse effects of remdesivir for the treatment of acute COVID-19 in the pediatric population: a retrospective observational study
Although the severity of coronavirus disease 2019 (COVID-19) tends to be lower in children, it can still lead to severe illness, particularly among those with chronic medical conditions. While remdesivir (RDV)...
Citation: Molecular and Cellular Pediatrics 2024 11:2 -
The role of regulatory B cells in immune regulation and childhood allergic asthma
As the most common chronic disease in childhood, asthma displays a major public health problem worldwide with the incidence of those affected rising. As there is currently no cure for allergic asthma, it is ma...
Citation: Molecular and Cellular Pediatrics 2024 11:1 -
Phagocytic cell death leads to enhanced release of pro-inflammatory S100A12 in familial Mediterranean fever
Familial Mediterranean fever (FMF) is a prototypical autoinflammatory syndrome associated with phagocytic cell activation. Pyrin mutations are the genetic basis of this disease, and its expression has been sho...
Citation: Molecular and Cellular Pediatrics 2023 10:19 -
Installation of the developing nephron in the fetal human kidney during advanced pregnancy
The kidneys of preterm and low birth weight babies reflect vulnerability, since several noxae can evoke the termination of nephron formation. This again leads to oligonephropathy with severe consequences for h...
Citation: Molecular and Cellular Pediatrics 2023 10:18 -
Gene therapy-based strategies for spinal muscular atrophy—an Asia-Pacific perspective
Onasemnogene abeparvovec has been life-changing for children with spinal muscular atrophy (SMA), signifying the potential and progress occurring in gene- and cell-based therapies for rare genetic diseases. Hen...
Citation: Molecular and Cellular Pediatrics 2023 10:17 -
Relevance and consequence of chronic inflammation for obesity development
Increasing prevalence of morbid obesity accompanied by comorbidities like type 2 diabetes mellitus (T2DM) led to a demand for improving therapeutic strategies and pharmacological intervention options. Apart fr...
Citation: Molecular and Cellular Pediatrics 2023 10:16 -
B cell phenotype and serum levels of interferons, BAFF, and APRIL in multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C)
Multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C) is a late complication of pediatric COVID-19, which follows weeks after the original SARS-CoV-2 infection, regardless of its sever...
Citation: Molecular and Cellular Pediatrics 2023 10:15 -
A novel serum calprotectin (MRP8/14) particle-enhanced immuno-turbidimetric assay (sCAL turbo) helps to differentiate systemic juvenile idiopathic arthritis from other diseases in routine clinical laboratory settings
Differential diagnosis in children with signs of unprovoked inflammation can be challenging. In particular, differentiating systemic juvenile idiopathic arthritis (SJIA) from other diagnoses is difficult. We h...
Citation: Molecular and Cellular Pediatrics 2023 10:14 -
What do we know about the sleep effects of caffeine used to treat apnoea of prematurity? A systematic review of the literature
Scientific scrutiny has proved the safety and benefits of caffeine to treat apnoea of prematurity (AOP). However, there is no consensus on the effects of this treatment on sleep, especially considering the key...
Citation: Molecular and Cellular Pediatrics 2023 10:13 -
Retinopathy of prematurity: from oxygen management to molecular manipulation
Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the premature retina with the potential to progress to extraretinal neovascularisation. This review serves as an introduction to retinopathy ...
Citation: Molecular and Cellular Pediatrics 2023 10:12 -
Autoimmune lymphoproliferative immunodeficiencies (ALPID) in childhood: breakdown of immune homeostasis and immune dysregulation
Many inborn errors of immunity (IEI) manifest with hallmarks of both immunodeficiency and immune dysregulation due to uncontrolled immune responses and impaired immune homeostasis. A subgroup of these disorder...
Citation: Molecular and Cellular Pediatrics 2023 10:11 -
Characterization of adolescents with functional respiratory disorders and prior history of SARS-CoV-2
The SARS-CoV-2 pandemic has caused significant pulmonary morbidity and mortality in the adult population. Children and adolescents typically show milder symptoms; however, a relevant proportion of them report ...
Citation: Molecular and Cellular Pediatrics 2023 10:10 -
Childhood asthma phenotypes and endotypes: a glance into the mosaic
Asthma is an inflammatory lung disease that constitutes the most common noncommunicable chronic disease in childhood. Childhood asthma shows large heterogeneity regarding onset of disease, symptoms, severity, ...
Citation: Molecular and Cellular Pediatrics 2023 10:9 -
Sex differences in long-term kidney fibrosis following neonatal nephron loss during ongoing nephrogenesis
Clinical studies suggest that female sex plays a protective role in the development and progression of kidney disease. Recent experimental studies indicate that in male rats early nephron loss under ongoing ne...
Citation: Molecular and Cellular Pediatrics 2023 10:8 -
Real-world evidence study on tolerance and growth in infants fed an infant formula with two human milk oligosaccharides vs mixed fed and exclusively breastfed infants
Human milk oligosaccharides (HMOs) are important components of human milk having diverse functions in the development of infants. Randomized controlled trials (RCTs) have demonstrated that infant formulas with...
Citation: Molecular and Cellular Pediatrics 2023 10:7 -
Metamizole-induced agranulocytosis (MIA): a mini review
Metamizole is an analgesic, antipyretic, and spasmolytic drug in Germany only approved for the treatment of severe pain or high fever that does not respond to other measures. In recent years, an increased use ...
Citation: Molecular and Cellular Pediatrics 2023 10:6 -
Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE)
Systemic lupus erythematosus (SLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Approximately 15–20% of SLE patients develop the disease during childhood or adolescence (...
Citation: Molecular and Cellular Pediatrics 2023 10:5 -
Perinatal origins of bronchopulmonary dysplasia—deciphering normal and impaired lung development cell by cell
Bronchopulmonary dysplasia (BPD) is a multifactorial disease occurring as a consequence of premature birth, as well as antenatal and postnatal injury to the developing lung. BPD morbidity and severity depend o...
Citation: Molecular and Cellular Pediatrics 2023 10:4 -
New insights into the immune functions of podocytes: the role of complement
Podocytes are differentiated epithelial cells which play an essential role to ensure a normal function of the glomerular filtration barrier (GFB). In addition to their adhesive properties in maintaining the in...
Citation: Molecular and Cellular Pediatrics 2023 10:3 -
Modelling human lower urinary tract malformations in zebrafish
Advances in molecular biology are improving our understanding of the genetic causes underlying human congenital lower urinary tract (i.e., bladder and urethral) malformations. This has recently led to the iden...
Citation: Molecular and Cellular Pediatrics 2023 10:2 -
Umbilical catheter placement aided by coronary guidewires
Catheterization of the umbilical vessels has proven to be an effective and relatively rapid method for gaining central vascular access in neonates. However, it can be technically difficult, the procedure may l...
Citation: Molecular and Cellular Pediatrics 2023 10:1 -
Non-invasive pediatric cardiac imaging—current status and further perspectives
Non-invasive cardiac imaging has a growing role in diagnosis, differential diagnosis, therapy planning, and follow-up in children and adolescents with congenital and acquired cardiac diseases. This review is b...
Citation: Molecular and Cellular Pediatrics 2022 9:21 -
Adsorption of insulin onto neonatal infusion sets: should intravenous administration of insulin to treat hyperglycemia in preterm babies on the NICU be proceeded by priming of the intravenous system, adding of albumin, or non-priming to get to a stable insulin dose?
Insulin is used to treat neonatal hyperglycaemia when blood glucose concentrations are consistently high, and to treat neonatal diabetes. Within this brief report, a review of the existing literature is conduc...
Citation: Molecular and Cellular Pediatrics 2022 9:20 -
Molecular detection and characterization of Shigella spp. harboring extended-spectrum β-lactamase genes in children with diarrhea in northwest Iran
Shigellosis is one of the acute bowel infections and remains a serious public health problem in resource-poor countries. The present study aimed to survey the distribution of extended-spectrum β-lactamase (ESBL)-...
Citation: Molecular and Cellular Pediatrics 2022 9:19 -
Subcutaneous fat necrosis in newborns: a systematic literature review of case reports and model of pathophysiology
Subcutaneous fat necrosis of the newborn (SCFN) is a rare disease occurring in the first days of life. Characteristically, the infants show hard nodules in subcutaneous tissue, purple or erythematous in color ...
Citation: Molecular and Cellular Pediatrics 2022 9:18 -
The interstitium at the developing nephron in the fetal kidney during advanced pregnancy — a microanatomical inventory
A series of noxae can evoke the termination of nephron formation in preterm and low birth weight babies. This results in oligonephropathy with severe consequences for health in the later life. Although the cli...
Citation: Molecular and Cellular Pediatrics 2022 9:17 -
Association of immune cell recruitment and BPD development
In the neonatal lung, exposure to both prenatal and early postnatal risk factors converge into the development of injury and ultimately chronic disease, also known as bronchopulmonary dysplasia (BPD). The focu...
Citation: Molecular and Cellular Pediatrics 2022 9:16 -
Correction: Infant formulas with synthetic oligosaccharides and respective marketing practices: Position Statement of the German Society for Child and Adolescent Medicine e.V. (DGKJ), Commission for Nutrition
Citation: Molecular and Cellular Pediatrics 2022 9:15 -
Infant formulas with synthetic oligosaccharides and respective marketing practices: Position Statement of the German Society for Child and Adolescent Medicine e.V. (DGKJ), Commission for Nutrition
Human milk contains more than 150 different oligosaccharides, which together are among to the quantitatively predominant solid components of breast milk. The oligosaccharide content and composition of human mi...
Citation: Molecular and Cellular Pediatrics 2022 9:14 -
High-resolution label-free mapping of murine kidney vasculature by raster-scanning optoacoustic mesoscopy: an ex vivo study
Chronic kidney disease (CKD) is a global burden affecting both children and adults. Novel imaging modalities hold great promise to visualize and quantify structural, functional, and molecular organ damage. The...
Citation: Molecular and Cellular Pediatrics 2022 9:13 -
Molecular mechanisms of Shigella effector proteins: a common pathogen among diarrheic pediatric population
Different gastrointestinal pathogens cause diarrhea which is a very common problem in children aged under 5 years. Among bacterial pathogens, Shigella is one of the main causes of diarrhea among children, and it ...
Citation: Molecular and Cellular Pediatrics 2022 9:12 -
Ultrasound elastography in children — nice to have for scientific studies or arrived in clinical routine?
Ultrasound elastography (USE) is a modality that in addition to fundamental B-mode, Doppler, and contrast-enhanced sonography is suitable to make qualitative and quantitative statements about the stiffness of ...
Citation: Molecular and Cellular Pediatrics 2022 9:11 -
Long noncoding RNAs as regulators of pediatric acute myeloid leukemia
Long noncoding RNAs (lncRNAs) are increasingly emerging as regulators across human development and disease, and many have been described in the context of hematopoiesis and leukemogenesis. These studies have y...
Citation: Molecular and Cellular Pediatrics 2022 9:10 -
How peritoneal dialysis transforms the peritoneum and vasculature in children with chronic kidney disease—what can we learn for future treatment?
Children with chronic kidney disease (CKD) suffer from inflammation and reactive metabolite-induced stress, which massively accelerates tissue and vascular aging. Peritoneal dialysis (PD) is the preferred dial...
Citation: Molecular and Cellular Pediatrics 2022 9:9 -
When inflammation meets lung development—an update on the pathogenesis of bronchopulmonary dysplasia
Even more than 50 years after its initial description, bronchopulmonary dysplasia (BPD) remains one of the most important and lifelong sequelae following premature birth. Tremendous efforts have been undertake...
Citation: Molecular and Cellular Pediatrics 2022 9:7 -
Implementation of exclusive enteral nutrition in pediatric patients with Crohn’s disease—results of a survey of CEDATA-GPGE reporting centers
Exclusive enteral nutrition (EEN) is the first-line therapy for pediatric-onset Crohn’s disease (CD) patients. CEDATA-GPGE® is the largest patient registry for children and adolescents with inflammatory bowel ...
Citation: Molecular and Cellular Pediatrics 2022 9:6 -
Uni-ventricular palliation vs. bi-ventricular repair: differential inflammatory response
To examine whether uni-ventricular palliation (UVP) and bi-ventricular repair (BVR) result in a different pattern of systemic inflammatory response to pediatric cardiac surgery with extra-corporeal circulation...
Citation: Molecular and Cellular Pediatrics 2022 9:5 -
Correction to: Precision medicine in pediatric oncology
Citation: Molecular and Cellular Pediatrics 2022 9:8 -
DMBT1 is upregulated in cystic fibrosis, affects ciliary motility, and is reduced by acetylcysteine
Cystic fibrosis (CF) is the most common genetic disorder in the Caucasian population. Despite remarkable improvements in morbidity and mortality during the last decades, the disease still limits survival and r...
Citation: Molecular and Cellular Pediatrics 2022 9:4 -
PTEN hamartoma tumor syndrome in childhood and adolescence—a comprehensive review and presentation of the German pediatric guideline
The PTEN hamartoma tumor syndrome (PHTS) encompasses several different syndromes, which are linked to an autosomal-dominant mutation of the tumor suppressor PTEN gene on chromosome 10. Loss of PTEN activity leads...
Citation: Molecular and Cellular Pediatrics 2022 9:3 -
Evaluation of phenotypic and genotypic patterns of aminoglycoside resistance in the Gram-negative bacteria isolates collected from pediatric and general hospitals
The purpose of the current study was to evaluate the phenotypic and genotypic patterns of aminoglycoside resistance among the Gram-negative bacteria (GNB) isolates collected from pediatric and general hospital...
Citation: Molecular and Cellular Pediatrics 2022 9:2 -
DMBT1 expression and neutrophil-to-lymphocyte ratio during necrotizing enterocolitis are influenced by impaired perfusion due to cardiac anomalies
Deleted in malignant brain tumors 1 (DMBT1) is involved in innate immunity and epithelial differentiation. It has been proven to play a role in various states of inflammation or hypoxia of fetal gastrointestin...
Citation: Molecular and Cellular Pediatrics 2022 9:1 -
Perinatal origins of chronic lung disease: mechanisms–prevention–therapy—sphingolipid metabolism and the genetic and perinatal origins of childhood asthma
Childhood asthma derives from complex host-environment interactions occurring in the perinatal and infant period, a critical time for lung development. Sphingolipids are bioactive molecules consistently implic...
Citation: Molecular and Cellular Pediatrics 2021 8:22 -
Patho-mechanisms of the origins of bronchopulmonary dysplasia
Bronchopulmonary dysplasia (BPD) continues to be one of the most common complications of prematurity, despite significant advancement in neonatology over the last couple of decades. The new BPD is characterize...
Citation: Molecular and Cellular Pediatrics 2021 8:21 -
Translational research approaches to study pediatric polycystic kidney disease
Polycystic kidney diseases (PKD) are severe forms of genetic kidney disorders. The two main types of PKD are autosomal recessive and autosomal dominant PKD (ARPKD, ADPKD). While ARPKD typically is a disorder o...
Citation: Molecular and Cellular Pediatrics 2021 8:20 -
Imaging of peripheral vascular malformations — current concepts and future perspectives
Vascular Malformations belong to the spectrum of orphan diseases and can involve all segments of the vascular tree: arteries, capillaries, and veins, and similarly the lymphatic vasculature. The classification...
Citation: Molecular and Cellular Pediatrics 2021 8:19 -
The role of the immune system in idiopathic nephrotic syndrome
Idiopathic nephrotic syndrome (INS) in children is characterized by massive proteinuria and hypoalbuminemia and usually responds well to steroids. However, relapses are frequent, which can require multi-drug t...
Citation: Molecular and Cellular Pediatrics 2021 8:18
- ISSN: 2194-7791 (electronic)