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  1. Bronchopulmonary dysplasia (BPD) is a multifactorial disease occurring as a consequence of premature birth, as well as antenatal and postnatal injury to the developing lung. BPD morbidity and severity depend o...

    Authors: I. Mižíková and B. Thébaud
    Citation: Molecular and Cellular Pediatrics 2023 10:4
  2. Advances in molecular biology are improving our understanding of the genetic causes underlying human congenital lower urinary tract (i.e., bladder and urethral) malformations. This has recently led to the iden...

    Authors: Caroline M. Kolvenbach, Gabriel C. Dworschak, Johanna M. Rieke, Adrian S. Woolf, Heiko Reutter, Benjamin Odermatt and Alina C. Hilger
    Citation: Molecular and Cellular Pediatrics 2023 10:2
  3. Catheterization of the umbilical vessels has proven to be an effective and relatively rapid method for gaining central vascular access in neonates. However, it can be technically difficult, the procedure may l...

    Authors: Katarzyna Gendera, Stanimir Georgiev, Peter Ewert, Stefan Eckstein, Christoph Fusch and Niels Rochow
    Citation: Molecular and Cellular Pediatrics 2023 10:1
  4. Non-invasive cardiac imaging has a growing role in diagnosis, differential diagnosis, therapy planning, and follow-up in children and adolescents with congenital and acquired cardiac diseases. This review is b...

    Authors: Meinrad Beer, Björn Schönnagel, Jochen Herrmann, Steffen Klömpken, Matthias Schaal, Michael Kaestner, Christian Apitz and Horst Brunner
    Citation: Molecular and Cellular Pediatrics 2022 9:21
  5. Insulin is used to treat neonatal hyperglycaemia when blood glucose concentrations are consistently high, and to treat neonatal diabetes. Within this brief report, a review of the existing literature is conduc...

    Authors: Paola Mian, Mathieu S. Bolhuis, J. Marina Maurer and Margriet van Stuijvenberg
    Citation: Molecular and Cellular Pediatrics 2022 9:20
  6. Shigellosis is one of the acute bowel infections and remains a serious public health problem in resource-poor countries. The present study aimed to survey the distribution of extended-spectrum β-lactamase (ESBL)-...

    Authors: Sahar Sabour, Amir Teimourpour, Jafar Mohammadshahi, Hadi Peeridogaheh, Roghayeh Teimourpour, Taher Azimi and Zahra Hosseinali
    Citation: Molecular and Cellular Pediatrics 2022 9:19
  7. Subcutaneous fat necrosis of the newborn (SCFN) is a rare disease occurring in the first days of life. Characteristically, the infants show hard nodules in subcutaneous tissue, purple or erythematous in color ...

    Authors: Leonie Frank, Stephanie Brandt and Martin Wabitsch
    Citation: Molecular and Cellular Pediatrics 2022 9:18
  8. In the neonatal lung, exposure to both prenatal and early postnatal risk factors converge into the development of injury and ultimately chronic disease, also known as bronchopulmonary dysplasia (BPD). The focu...

    Authors: Motaharehsadat Heydarian, Christian Schulz, Tobias Stoeger and Anne Hilgendorff
    Citation: Molecular and Cellular Pediatrics 2022 9:16
  9. Authors: Christoph Bührer, Regina Ensenauer, Frank Jochum, Hermann Kalhoff, Berthold Koletzko, Burkhard Lawrenz, Walter Mihatsch, Carsten Posovszky and Silvia Rudloff
    Citation: Molecular and Cellular Pediatrics 2022 9:15

    The original article was published in Molecular and Cellular Pediatrics 2022 9:14

  10. Human milk contains more than 150 different oligosaccharides, which together are among to the quantitatively predominant solid components of breast milk. The oligosaccharide content and composition of human mi...

    Authors: Christoph Bührer, Regina Ensenauer, Frank Jochum, Hermann Kalhoff, Berthold Koletzko, Burkhard Lawrenz, Walter Mihatsch, Carsten Posovszky and Silvia Rudloff
    Citation: Molecular and Cellular Pediatrics 2022 9:14

    The Correction to this article has been published in Molecular and Cellular Pediatrics 2022 9:15

  11. Chronic kidney disease (CKD) is a global burden affecting both children and adults. Novel imaging modalities hold great promise to visualize and quantify structural, functional, and molecular organ damage. The...

    Authors: Colin A. Goebel, Emma Brown, Fabian B. Fahlbusch, Alexandra L. Wagner, Adrian Buehler, Thomas Raupach, Martin Hohmann, Moritz Späth, Neal Burton, Joachim Woelfle, Michael Schmidt, Andrea Hartner, Adrian P. Regensburger and Ferdinand Knieling
    Citation: Molecular and Cellular Pediatrics 2022 9:13
  12. Different gastrointestinal pathogens cause diarrhea which is a very common problem in children aged under 5 years. Among bacterial pathogens, Shigella is one of the main causes of diarrhea among children, and it ...

    Authors: Ahmad Nasser, Mehrdad Mosadegh, Taher Azimi and Aref Shariati
    Citation: Molecular and Cellular Pediatrics 2022 9:12
  13. Ultrasound elastography (USE) is a modality that in addition to fundamental B-mode, Doppler, and contrast-enhanced sonography is suitable to make qualitative and quantitative statements about the stiffness of ...

    Authors: Hans-Joachim Mentzel, Katja Glutig, Stephanie Gräger, Paul-Christian Krüger and Matthias Waginger
    Citation: Molecular and Cellular Pediatrics 2022 9:11
  14. Long noncoding RNAs (lncRNAs) are increasingly emerging as regulators across human development and disease, and many have been described in the context of hematopoiesis and leukemogenesis. These studies have y...

    Authors: Sina Neyazi, Michelle Ng, Dirk Heckl and Jan-Henning Klusmann
    Citation: Molecular and Cellular Pediatrics 2022 9:10
  15. Children with chronic kidney disease (CKD) suffer from inflammation and reactive metabolite-induced stress, which massively accelerates tissue and vascular aging. Peritoneal dialysis (PD) is the preferred dial...

    Authors: Maria Bartosova, Sotirios G. Zarogiannis and Claus Peter Schmitt
    Citation: Molecular and Cellular Pediatrics 2022 9:9
  16. Even more than 50 years after its initial description, bronchopulmonary dysplasia (BPD) remains one of the most important and lifelong sequelae following premature birth. Tremendous efforts have been undertake...

    Authors: Lena Holzfurtner, Tayyab Shahzad, Ying Dong, Lisa Rekers, Ariane Selting, Birte Staude, Tina Lauer, Annesuse Schmidt, Stefano Rivetti, Klaus-Peter Zimmer, Judith Behnke, Saverio Bellusci and Harald Ehrhardt
    Citation: Molecular and Cellular Pediatrics 2022 9:7
  17. Exclusive enteral nutrition (EEN) is the first-line therapy for pediatric-onset Crohn’s disease (CD) patients. CEDATA-GPGE® is the largest patient registry for children and adolescents with inflammatory bowel ...

    Authors: Sarah Peters, Serdar Cantez and Jan De Laffolie
    Citation: Molecular and Cellular Pediatrics 2022 9:6
  18. To examine whether uni-ventricular palliation (UVP) and bi-ventricular repair (BVR) result in a different pattern of systemic inflammatory response to pediatric cardiac surgery with extra-corporeal circulation...

    Authors: Matthias Sigler, Hatem Rouatbi, Jaime Vazquez-Jimenez and Marie-Christine Seghaye
    Citation: Molecular and Cellular Pediatrics 2022 9:5
  19. Cystic fibrosis (CF) is the most common genetic disorder in the Caucasian population. Despite remarkable improvements in morbidity and mortality during the last decades, the disease still limits survival and r...

    Authors: Alexander Kiefer, Erika Plattner, Renate Ruppel, Christel Weiss, Zhe Zhou-Suckow, Marcus Mall, Marcus Renner and Hanna Müller
    Citation: Molecular and Cellular Pediatrics 2022 9:4
  20. The PTEN hamartoma tumor syndrome (PHTS) encompasses several different syndromes, which are linked to an autosomal-dominant mutation of the tumor suppressor PTEN gene on chromosome 10. Loss of PTEN activity leads...

    Authors: Michaela Plamper, Bettina Gohlke and Joachim Woelfle
    Citation: Molecular and Cellular Pediatrics 2022 9:3
  21. The purpose of the current study was to evaluate the phenotypic and genotypic patterns of aminoglycoside resistance among the Gram-negative bacteria (GNB) isolates collected from pediatric and general hospital...

    Authors: Leila Azimi, Shahnaz Armin, Hossein Samadi Kafil, Nafiseh Abdollahi, Kiarash Ghazvini, Sepide Hasanzadeh, Shahram Shahraki Zahedani, Sedigheh Rafiei Tabatabaei and Fatemeh Fallah
    Citation: Molecular and Cellular Pediatrics 2022 9:2
  22. Deleted in malignant brain tumors 1 (DMBT1) is involved in innate immunity and epithelial differentiation. It has been proven to play a role in various states of inflammation or hypoxia of fetal gastrointestin...

    Authors: Sonja Diez, Manuel Besendörfer, Veronika Weyerer, Arndt Hartmann, Julia Moosmann, Christel Weiss, Marcus Renner and Hanna Müller
    Citation: Molecular and Cellular Pediatrics 2022 9:1
  23. Childhood asthma derives from complex host-environment interactions occurring in the perinatal and infant period, a critical time for lung development. Sphingolipids are bioactive molecules consistently implic...

    Authors: Emily Wasserman and Stefan Worgall
    Citation: Molecular and Cellular Pediatrics 2021 8:22
  24. Bronchopulmonary dysplasia (BPD) continues to be one of the most common complications of prematurity, despite significant advancement in neonatology over the last couple of decades. The new BPD is characterize...

    Authors: Mitali Sahni and Vineet Bhandari
    Citation: Molecular and Cellular Pediatrics 2021 8:21
  25. Vascular Malformations belong to the spectrum of orphan diseases and can involve all segments of the vascular tree: arteries, capillaries, and veins, and similarly the lymphatic vasculature. The classification...

    Authors: Vanessa F. Schmidt, Max Masthoff, Michael Czihal, Beatrix Cucuruz, Beate Häberle, Richard Brill, Walter A. Wohlgemuth and Moritz Wildgruber
    Citation: Molecular and Cellular Pediatrics 2021 8:19
  26. Idiopathic nephrotic syndrome (INS) in children is characterized by massive proteinuria and hypoalbuminemia and usually responds well to steroids. However, relapses are frequent, which can require multi-drug t...

    Authors: Agnes Hackl, Seif El Din Abo Zed, Paul Diefenhardt, Julia Binz-Lotter, Rasmus Ehren and Lutz Thorsten Weber
    Citation: Molecular and Cellular Pediatrics 2021 8:18
  27. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has improved survival in high-risk childhood leukemia but is associated with long-term sequelae such as impaired pulmonary function and reduced ex...

    Authors: Katharina Ruf, Alaa Badran, Céline Siauw, Imme Haubitz, Paul-Gerhardt Schlegel, Helge Hebestreit, Christoph Härtel and Verena Wiegering
    Citation: Molecular and Cellular Pediatrics 2021 8:16
  28. Cardiovascular complications are the major cause of the marked morbidity and mortality associated with chronic kidney disease (CKD). The classical cardiovascular risk factors such as diabetes and hypertension ...

    Authors: Julia Schlender, Felix Behrens, Victoria McParland, Dominik Müller, Nicola Wilck, Hendrik Bartolomaeus and Johannes Holle
    Citation: Molecular and Cellular Pediatrics 2021 8:17
  29. DSTYK encodes dual serine/threonine and tyrosine protein kinase. DSTYK has been associated with autosomal-dominant congenital anomalies of the kidney and urinary tract and with autosomal-recessive hereditary spas...

    Authors: Clara Vidic, Marcin Zaniew, Szymon Jurga, Holger Thiele, Heiko Reutter and Alina C. Hilger
    Citation: Molecular and Cellular Pediatrics 2021 8:13
  30. Chronic kidney disease (CKD) is associated with distinct alterations in mineral metabolism in children and adults resulting in multiple organ dysfunctions. Children with advanced CKD often suffer from impaired...

    Authors: Maren Leifheit-Nestler and Dieter Haffner
    Citation: Molecular and Cellular Pediatrics 2021 8:12
  31. Immune thrombocytopenia (ITP) is an autoimmune disease associated with isolated thrombocytopenia, which is caused by an imbalance between platelet production and platelet destruction. Petechial and mucous memb...

    Authors: Hannah von Lukowicz, Paul-Gerhardt Schlegel, Christoph Härtel, Henner Morbach, Imme Haubitz and Verena Wiegering
    Citation: Molecular and Cellular Pediatrics 2021 8:11
  32. Leptin (LEP) and leptin receptor (LEPR) play a major role in energy homeostasis, metabolism, and reproductive function. While effects of biallelic likely pathogenic variants (-/-) on the phenotype are well charac...

    Authors: Ingrid Koerber-Rosso, Stephanie Brandt, Julia von Schnurbein, Pamela Fischer-Posovszky, Josef Hoegel, Hannah Rabenstein, Reiner Siebert and Martin Wabitsch
    Citation: Molecular and Cellular Pediatrics 2021 8:10
  33. The impairment of nephrogenesis can cause the termination of nephron formation in preterm and low birth weight babies. This leads to oligonephropathy with severe health consequences in later life. Although man...

    Authors: Will W. Minuth
    Citation: Molecular and Cellular Pediatrics 2021 8:9
  34. After pediatric kidney transplantation, immunosuppressive therapy is given to avoid acute and chronic rejections. However, the immunosuppression causes an increased risk of severe viral complications and bacte...

    Authors: Thurid Ahlenstiel-Grunow and Lars Pape
    Citation: Molecular and Cellular Pediatrics 2021 8:8

    The Correction to this article has been published in Molecular and Cellular Pediatrics 2021 8:14

  35. Infantile myofibromatosis (IM) is the most common cause of multiple fibrous tumors in infancy. Multicentric disease can be associated with life-threatening visceral lesions. Germline gain-of-function mutations...

    Authors: Tristan Römer, Norbert Wagner, Till Braunschweig, Robert Meyer, Miriam Elbracht, Udo Kontny and Olga Moser
    Citation: Molecular and Cellular Pediatrics 2021 8:7
  36. Ca2+ as a universal second messenger regulates basic biological functions including cell cycle, cell proliferation, cell differentiation, and cell death. Lack of the protein mitochondrial calcium uptake1 (MICU1),...

    Authors: Fatemeh Bitarafan, Mehrnoosh Khodaeian, Elham Amjadi Sardehaei, Fatemeh Zahra Darvishi, Navid Almadani, Yalda Nilipour and Masoud Garshasbi
    Citation: Molecular and Cellular Pediatrics 2021 8:6
  37. Immune-mediated cytopenias (AIC) are challenging complications following allogeneic hematopoietic stem cell transplantation (HSCT). While broad-acting immunosuppressive agents like corticosteroids are often st...

    Authors: Lina Driouk, Robert Schmitt, Anke Peters, Sabine Heine, Hermann Josef Girschick, Brigitte Strahm, Charlotte M. Niemeyer and Carsten Speckmann
    Citation: Molecular and Cellular Pediatrics 2021 8:5
  38. Reverse transcription of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (+)RNA genome and subgenomic RNAs (sgRNAs) and subsequent quantitative polymerase chain reaction (RT-qPCR) is the relia...

    Authors: Patrick Philipp Weil, Jacqueline Hentschel, Frank Schult, Anton Pembaur, Beniam Ghebremedhin, Olivier Mboma, Andreas Heusch, Anna-Christin Reuter, Daniel Müller, Stefan Wirth, Malik Aydin, Andreas C. W. Jenke and Jan Postberg
    Citation: Molecular and Cellular Pediatrics 2021 8:4
  39. Sex hormone-binding globulin (SHBG) levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNFα) plasma levels ...

    Authors: Marta Ramon-Krauel, María Jesús Leal-Witt, Óscar Osorio-Conles, Montse Amat-Bou, Carles Lerin and David M. Selva
    Citation: Molecular and Cellular Pediatrics 2021 8:3
  40. Congenital anomalies of the kidney and urinary tract (CAKUT) occur in 0.5–1/100 newborns and as a group they represent the most frequent cause for chronic kidney failure in children. CAKUT comprise clinically ...

    Authors: Stefan Kohl, Sandra Habbig, Lutz T. Weber and Max C. Liebau
    Citation: Molecular and Cellular Pediatrics 2021 8:2
  41. Epidermal development is a complex process of regulated cellular proliferation, differentiation, and tightly controlled cell death involving multiple cellular signaling networks. Here, we report a first descri...

    Authors: Claudia Dafinger, Thomas Benzing, Jörg Dötsch, Bernhard Schermer and Max C. Liebau
    Citation: Molecular and Cellular Pediatrics 2021 8:1
  42. Authors: Ruth Janoschek, Thorben Hoffmann, Yousef Ashraf Tawfik Morcos, Gerhard Sengle, Jörg Dötsch and Eva Hucklenbruch-Rother
    Citation: Molecular and Cellular Pediatrics 2020 7:18
  43. In the last years, great advances have been made in the effort to understand how nutritional influences can affect long-term renal health. Evidence has accumulated that maternal nutrition before and during pre...

    Authors: Eva Nüsken, Jenny Voggel, Gregor Fink, Jörg Dötsch and Kai-Dietrich Nüsken
    Citation: Molecular and Cellular Pediatrics 2020 7:17