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  1. Content type: Review

    Antisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target a...

    Authors: Kelly M. Martinovich, Nicole C. Shaw, Anthony Kicic, André Schultz, Sue Fletcher, Steve D. Wilton and Stephen M. Stick

    Citation: Molecular and Cellular Pediatrics 2018 5:3

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  2. Content type: Research

    Impaired regulatory T cell immunity plays a central role in the development of type 1 diabetes (T1D). Interleukin-2 receptor (IL-2R) signaling is essential for regulatory T cells (TREG), and cytokine-inducible SH...

    Authors: Julia Seyfarth, Heinz Ahlert, Joachim Rosenbauer, Christina Baechle, Michael Roden, Reinhard W. Holl, Ertan Mayatepek, Thomas Meissner and Marc Jacobsen

    Citation: Molecular and Cellular Pediatrics 2018 5:2

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  3. Content type: Research

    Children with inflammatory bowel disease (IBD) or autoimmune hepatitis (AIH) are at risk for severe infections. This is partially a result of their chronic disease condition but, moreover, a side effect of the...

    Authors: Teresa Schleker, Eva-Maria Jacobsen, Benjamin Mayer, Gudrun Strauss, Klaus-Michael Debatin and Carsten Posovszky

    Citation: Molecular and Cellular Pediatrics 2018 5:1

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  4. Content type: Review

    Numerous investigations are dealing with anlage of the mammalian kidney and primary development of nephrons. However, only few information is available about the last steps in kidney development leading at bir...

    Authors: Will W. Minuth

    Citation: Molecular and Cellular Pediatrics 2017 4:12

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  5. Content type: Research

    Mutations in the leptin gene (LEP) can alter the secretion or interaction of leptin with its receptor, leading to extreme early-onset obesity. The purpose of this work was to estimate the prevalence of heteroz...

    Authors: Adriana Nunziata, Guntram Borck, Jan-Bernd Funcke, Katja Kohlsdorf, Stephanie Brandt, Anke Hinney, Barbara Moepps, Peter Gierschik, Klaus-Michael Debatin, Pamela Fischer-Posovszky and Martin Wabitsch

    Citation: Molecular and Cellular Pediatrics 2017 4:10

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  6. Content type: Case Study

    Transcatheter closure has become the treatment of choice for secundum atrial septal defects (ASD II), but particularly in small children, there is concern regarding procedure-related complications.

    Authors: Roman Scheidmann, Thomas Paul and Matthias Sigler

    Citation: Molecular and Cellular Pediatrics 2017 4:9

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  7. Content type: Short Communication

    Autism spectrum disorders (ASDs) are neurodevelopmental disorders with impaired social interactions and communication and restrictive, repetitive patterns of behaviors, interests, and activities. A recent epid...

    Authors: Michaela Kuhlen, Julia Taeubner, Dagmar Wieczorek and Arndt Borkhardt

    Citation: Molecular and Cellular Pediatrics 2017 4:8

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  8. Content type: Mini review

    Chronic non-bacterial osteomyelitis (CNO) belongs to the growing spectrum of autoinflammatory diseases and primarily affects the skeletal system. Peak onset ranges between 7 and 12 years of age. The clinical s...

    Authors: Sigrun Ruth Hofmann, Franz Kapplusch, Katrin Mäbert and Christian Michael Hedrich

    Citation: Molecular and Cellular Pediatrics 2017 4:7

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  9. Content type: Review

    Precursor B acute lymphoblastic leukemia (BCP-ALL), the most common childhood malignancy, arises from an expansion of malignant B cell precursors in the bone marrow. Epidemiological studies suggest that infect...

    Authors: Simone Bürgler and David Nadal

    Citation: Molecular and Cellular Pediatrics 2017 4:6

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  10. Content type: Meeting abstracts

    Authors: Rhea van den Bruck, Patrick P. Weil, Thomas Ziegenhals, Philipp Schreiner, Stefan Juranek, Daniel Gödde, Silvia Vogel, Frauke Schuster, Valerie Orth, Johannes Dörner, Daniel Pembaur, Meike Röper, Stefan Störkel, Hubert Zirngibl, Stefan Wirth, Andreas C. W. Jenke…

    Citation: Molecular and Cellular Pediatrics 2017 4(Suppl 1):5

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    This article is part of a Supplement: Volume 4 Supplement 1

  11. Content type: Review

    The intrauterine environment was long considered sterile. However, several infectious threats are already present during fetal life. This review focuses on the postnatal immunological consequences of prenatal ...

    Authors: Gijs T. J. van Well, Leonie A. Daalderop, Tim Wolfs and Boris W. Kramer

    Citation: Molecular and Cellular Pediatrics 2017 4:4

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  12. Content type: Short Communication

    Exposure to second-hand tobacco smoke (SHS) is one of the prime risk factors for chronic lung disease development. Smoking during pregnancy may lead to birth defects in the newborn that include pulmonary dysfu...

    Authors: Neel Patel, Christopher D. Trumph, Manish Bodas and Neeraj Vij

    Citation: Molecular and Cellular Pediatrics 2017 4:3

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  13. Content type: Review

    The developmental origin of health and disease concept identifies the brain, cardiovascular, liver, and kidney systems as targets of fetal adverse programming with adult consequences. As the limits of viabilit...

    Authors: Amelie Stritzke, Sumesh Thomas, Harish Amin, Christoph Fusch and Abhay Lodha

    Citation: Molecular and Cellular Pediatrics 2017 4:2

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  14. Content type: Review

    The pathological course of several chronic inflammatory diseases, including cystic fibrosis, chronic obstructive pulmonary disease, and rheumatoid arthritis, features an aberrant innate immune response dominat...

    Authors: Camilla Margaroli and Rabindra Tirouvanziam

    Citation: Molecular and Cellular Pediatrics 2016 3:38

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  15. Content type: Research

    Rett syndrome is best known due to its severe and devastating symptoms in the central nervous system. It is produced by mutations affecting the Mecp2 gene that codes for a transcription factor. Nevertheless, evid...

    Authors: Pamela Millar-Büchner, Amber R. Philp, Noemí Gutierrez, Sandra Villanueva, Bredford Kerr and Carlos A. Flores

    Citation: Molecular and Cellular Pediatrics 2016 3:37

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  16. Content type: Research

    Wilms’ tumor is an embryonal neoplasm of the kidney that accounts for approximately 6 % of all childhood tumors. The chemokine CXCL12 (C-X-C chemokine ligand 12) and its ligand CXCR4 (C-X-C chemokine receptor ...

    Authors: Patricia Midori Murobushi Ozawa, Carolina Batista Ariza, Roberta Losi-Guembarovski, Alda Losi Guembarovski, Carlos Eduardo Coral de Oliveira, Bruna Karina Banin-Hirata, Marina Okuyama Kishima, Diego Lima Petenuci and Maria Angelica Ehara Watanabe

    Citation: Molecular and Cellular Pediatrics 2016 3:36

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  17. Content type: Mini review

    Impaired cellular innate immune defense accounts for susceptibility to sepsis and its high morbidity and mortality in preterm infants. Leukocyte recruitment is an integral part of the cellular immune response ...

    Authors: Katinka Karenberg, Hannes Hudalla and David Frommhold

    Citation: Molecular and Cellular Pediatrics 2016 3:35

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  18. Content type: Review

    Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due...

    Authors: Chiharu Ota, Hoeke A. Baarsma, Darcy E. Wagner, Anne Hilgendorff and Melanie Königshoff

    Citation: Molecular and Cellular Pediatrics 2016 3:34

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  19. Content type: Short Communication

    Neonatal leukemia is a rare disease with an estimated prevalence of about one to five in a million neonates. The majority being acute myeloid leukemia (AML), neonatal leukemia can present with a variety of sym...

    Authors: Tobias Gyárfás, Juergen Wintgens, Wolfgang Biskup, Ilske Oschlies, Wolfram Klapper, Reiner Siebert, Susanne Bens, Claudia Haferlach, Roland Meisel, Michaela Kuhlen and Arndt Borkhardt

    Citation: Molecular and Cellular Pediatrics 2016 3:30

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  20. Content type: Case Study

    Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limited recurrent attacks of fever and serositis. Patients may develop renal amyloidosis. Colchicine prevents attacks ...

    Authors: Betul Sozeri, Nesrin Gulez, Malik Ergin and Erkin Serdaroglu

    Citation: Molecular and Cellular Pediatrics 2016 3:33

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