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  1. Review

    The potential of antisense oligonucleotide therapies for inherited childhood lung diseases

    Antisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target a...

    Kelly M. Martinovich, Nicole C. Shaw, Anthony Kicic, André Schultz, Sue Fletcher, Steve D. Wilton and Stephen M. Stick

    Molecular and Cellular Pediatrics 2018 5:3

    Published on: 6 February 2018

  2. Research

    CISH promoter polymorphism effects on T cell cytokine receptor signaling and type 1 diabetes susceptibility

    Impaired regulatory T cell immunity plays a central role in the development of type 1 diabetes (T1D). Interleukin-2 receptor (IL-2R) signaling is essential for regulatory T cells (TREG), and cytokine-inducible SH...

    Julia Seyfarth, Heinz Ahlert, Joachim Rosenbauer, Christina Baechle, Michael Roden, Reinhard W. Holl, Ertan Mayatepek, Thomas Meissner and Marc Jacobsen

    Molecular and Cellular Pediatrics 2018 5:2

    Published on: 6 February 2018

  3. Research

    Preserved in vitro immunoreactivity in children receiving long-term immunosuppressive therapy due to inflammatory bowel disease or autoimmune hepatitis

    Children with inflammatory bowel disease (IBD) or autoimmune hepatitis (AIH) are at risk for severe infections. This is partially a result of their chronic disease condition but, moreover, a side effect of the...

    Teresa Schleker, Eva-Maria Jacobsen, Benjamin Mayer, Gudrun Strauss, Klaus-Michael Debatin and Carsten Posovszky

    Molecular and Cellular Pediatrics 2018 5:1

    Published on: 19 January 2018

  4. Research

    Estimated prevalence of potentially damaging variants in the leptin gene

    Mutations in the leptin gene (LEP) can alter the secretion or interaction of leptin with its receptor, leading to extreme early-onset obesity. The purpose of this work was to estimate the prevalence of heteroz...

    Adriana Nunziata, Guntram Borck, Jan-Bernd Funcke, Katja Kohlsdorf, Stephanie Brandt, Anke Hinney, Barbara Moepps, Peter Gierschik, Klaus-Michael Debatin, Pamela Fischer-Posovszky and Martin Wabitsch

    Molecular and Cellular Pediatrics 2017 4:10

    Published on: 3 November 2017

  5. Meeting abstracts

    Abstracts of the 52nd Workshop for Pediatric Research

    Rhea van den Bruck, Patrick P. Weil, Thomas Ziegenhals, Philipp Schreiner, Stefan Juranek, Daniel Gödde, Silvia Vogel, Frauke Schuster, Valerie Orth, Johannes Dörner, Daniel Pembaur, Meike Röper, Stefan Störkel, Hubert Zirngibl, Stefan Wirth, Andreas C. W. Jenke…

    Molecular and Cellular Pediatrics 2017 4(Suppl 1):5

    Published on: 10 May 2017

    This article is part of a Supplement: Volume 4 Supplement 1

  6. Review

    Human perinatal immunity in physiological conditions and during infection

    The intrauterine environment was long considered sterile. However, several infectious threats are already present during fetal life. This review focuses on the postnatal immunological consequences of prenatal ...

    Gijs T. J. van Well, Leonie A. Daalderop, Tim Wolfs and Boris W. Kramer

    Molecular and Cellular Pediatrics 2017 4:4

    Published on: 21 April 2017

  7. Review

    Renal consequences of preterm birth

    The developmental origin of health and disease concept identifies the brain, cardiovascular, liver, and kidney systems as targets of fetal adverse programming with adult consequences. As the limits of viabilit...

    Amelie Stritzke, Sumesh Thomas, Harish Amin, Christoph Fusch and Abhay Lodha

    Molecular and Cellular Pediatrics 2017 4:2

    Published on: 18 January 2017

  8. Research

    Severe changes in colon epithelium in the Mecp2-null mouse model of Rett syndrome

    Rett syndrome is best known due to its severe and devastating symptoms in the central nervous system. It is produced by mutations affecting the Mecp2 gene that codes for a transcription factor. Nevertheless, evid...

    Pamela Millar-Büchner, Amber R. Philp, Noemí Gutierrez, Sandra Villanueva, Bredford Kerr and Carlos A. Flores

    Molecular and Cellular Pediatrics 2016 3:37

    Published on: 21 November 2016

  9. Research

    Wilms’ tumor susceptibility: possible involvement of FOXP3 and CXCL12 genes

    Wilms’ tumor is an embryonal neoplasm of the kidney that accounts for approximately 6 % of all childhood tumors. The chemokine CXCL12 (C-X-C chemokine ligand 12) and its ligand CXCR4 (C-X-C chemokine receptor ...

    Patricia Midori Murobushi Ozawa, Carolina Batista Ariza, Roberta Losi-Guembarovski, Alda Losi Guembarovski, Carlos Eduardo Coral de Oliveira, Bruna Karina Banin-Hirata, Marina Okuyama Kishima, Diego Lima Petenuci and Maria Angelica Ehara Watanabe

    Molecular and Cellular Pediatrics 2016 3:36

    Published on: 10 November 2016

  10. Mini review

    Leukocyte recruitment in preterm and term infants

    Impaired cellular innate immune defense accounts for susceptibility to sepsis and its high morbidity and mortality in preterm infants. Leukocyte recruitment is an integral part of the cellular immune response ...

    Katinka Karenberg, Hannes Hudalla and David Frommhold

    Molecular and Cellular Pediatrics 2016 3:35

    Published on: 24 October 2016

  11. Short Communication

    Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus

    Neonatal leukemia is a rare disease with an estimated prevalence of about one to five in a million neonates. The majority being acute myeloid leukemia (AML), neonatal leukemia can present with a variety of sym...

    Tobias Gyárfás, Juergen Wintgens, Wolfgang Biskup, Ilske Oschlies, Wolfram Klapper, Reiner Siebert, Susanne Bens, Claudia Haferlach, Roland Meisel, Michaela Kuhlen and Arndt Borkhardt

    Molecular and Cellular Pediatrics 2016 3:30

    Published on: 29 August 2016

  12. Mini review

    Early origins of asthma (and allergy)

    Asthma is the most common chronic disease starting in childhood and persisting into adulthood in many cases. During childhood, different forms of asthma and wheezing disorders exist that can be discriminated b...

    Michael Kabesch

    Molecular and Cellular Pediatrics 2016 3:31

    Published on: 10 August 2016

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