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  1. About 150 human rhinovirus serotypes are responsible for more than 50 % of recurrent upper respiratory infections. Despite having similar 3D structures, some bind members of the low-density lipoprotein recepto...

    Authors: Dieter Blaas and Renate Fuchs
    Citation: Molecular and Cellular Pediatrics 2016 3:21
  2. Alveologenesis is the last stage in lung development and is essential for building the gas-exchanging units called alveoli. Despite intensive lung research, the intricate crosstalk between mesenchymal and epit...

    Authors: Cho-Ming Chao, Alena Moiseenko, Klaus-Peter Zimmer and Saverio Bellusci
    Citation: Molecular and Cellular Pediatrics 2016 3:17
  3. Asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) are all chronic pulmonary diseases, albeit with different etiologies, that are characterized by airflow limitation, chronic inflam...

    Authors: Robert C. Fellner, Shawn T. Terryah and Robert Tarran
    Citation: Molecular and Cellular Pediatrics 2016 3:16
  4. After birth, adequate lung function is necessary for the successful adaptation of a preterm baby. Both prenatal and postnatal insults and therapeutic interventions have an immediate effect on lung function and...

    Authors: Matthias C. Hütten, Tim G. A. M. Wolfs and Boris W. Kramer
    Citation: Molecular and Cellular Pediatrics 2016 3:15
  5. The maintenance of oxygen homeostasis in human tissues is mediated by several cellular adaptations in response to low-oxygen stress, called hypoxia. A decrease in tissue oxygen levels is initially counteracted...

    Authors: Nathalie E. Zeitouni, Sucheera Chotikatum, Maren von Köckritz-Blickwede and Hassan Y. Naim
    Citation: Molecular and Cellular Pediatrics 2016 3:14
  6. Cystic fibrosis (CF) is a lethal monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that entails the (diagnostic) increase in sweat electrolyte concent...

    Authors: Speranza Esposito, Antonella Tosco, Valeria R. Villella, Valeria Raia, Guido Kroemer and Luigi Maiuri
    Citation: Molecular and Cellular Pediatrics 2016 3:13
  7. Bacterial and fungal infections are hallmarks of cystic fibrosis (CF) lung disease. In the era of long-term inhaled antibiotics and increasing CF patient survival, new “emerging” pathogens are detected in CF a...

    Authors: Andreas Hector, Nina Frey and Dominik Hartl
    Citation: Molecular and Cellular Pediatrics 2016 3:12
  8. Incomplete intestinal absorption of fructose might lead to abdominal complaints such as pain, flatulence and diarrhoea. Whether defect fructose transporters such as GLUT5 or GLUT2 are involved in the pathogene...

    Authors: Karolin Ebert and Heiko Witt
    Citation: Molecular and Cellular Pediatrics 2016 3:10
  9. Bacterial infection often leads to cellular damage, primarily marked by loss of cellular integrity and cell death. However, in recent years, it is being increasingly recognized that, in individual cells, there...

    Authors: Helena Pillich, Maria Loose, Klaus-Peter Zimmer and Trinad Chakraborty
    Citation: Molecular and Cellular Pediatrics 2016 3:9
  10. Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Some gliadin peptides are not digested by intestinal proteases and can have diff...

    Authors: M. Vittoria Barone and K. Peter Zimmer
    Citation: Molecular and Cellular Pediatrics 2016 3:8
  11. Irritable bowel syndrome (IBS) is a common condition with a complex and largely unknown etiology. There is no cure, and treatment options are mainly directed to the amelioration of symptoms. IBS causes reduced...

    Authors: Maria Henström and Mauro D’Amato
    Citation: Molecular and Cellular Pediatrics 2016 3:7
  12. Perinatal complications in both term- and preterm-born infants are a leading cause of neonatal morbidities and mortality. Infants face different challenges in the neonatal intensive care unit with long-term mo...

    Authors: Martin Mueller, Tim G. A. Wolfs, Andreina Schoeberlein, Antonio W. D. Gavilanes, Daniel Surbek and Boris W. Kramer
    Citation: Molecular and Cellular Pediatrics 2016 3:6
  13. Primary sucrase-isomaltase deficiency, originally thought to be a homozygous recessive disorder, has been found to have numerous genetic variants that alone or in combination (compound heterozygosity) express ...

    Authors: Stanley A. Cohen
    Citation: Molecular and Cellular Pediatrics 2016 3:5
  14. Starch requires six enzymes for digestion to free glucose: two amylases (salivary and pancreatic) and four mucosal maltase activities; sucrase-isomaltase and maltase-glucoamylase. All are deficient in suckling...

    Authors: B. L. Nichols, M. Diaz-Sotomayor, S. E. Avery, S. K. Chacko, D. L. Hadsell, S. S. Baker, B. R. Hamaker, L. K. Yan, H. M. Lin and R. Quezada-Calvillo
    Citation: Molecular and Cellular Pediatrics 2016 3:4
  15. Microvillus inclusion disease (MVID) is characterised by onset of intractable life-threatening watery diarrhoea during infancy. Transmission electron microscopy demonstrates shortening or absence of apical mic...

    Authors: Georg F. Vogel, Michael W. Hess, Kristian Pfaller, Lukas A. Huber, Andreas R. Janecke and Thomas Müller
    Citation: Molecular and Cellular Pediatrics 2016 3:3
  16. Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the intestine. IBD is a multifactorial disorder, and IBD-associated genes are critical in innate immune response, inflammatory re...

    Authors: Yatrik M. Shah
    Citation: Molecular and Cellular Pediatrics 2016 3:1
  17. Childhood arterial ischemic stroke (CAIS) is increasingly recognized as an important cause of significant long-term morbidity in the pediatric population. Post stroke movement disorders, above all hemi-dystoni...

    Authors: Daniel Tibussek, Ertan Mayatepek, Dirk Klee and Anne Koy
    Citation: Molecular and Cellular Pediatrics 2015 2:14
  18. The immunogenicity and limited stability of conventional messenger RNA (mRNA) has traditionally restricted its potential therapeutic use. In 1992, the first clinical application of mRNA was reported as a poten...

    Authors: Justin S. Antony, Alexander Dewerth, Ashiqul Haque, Rupert Handgretinger and Michael S.D. Kormann
    Citation: Molecular and Cellular Pediatrics 2015 2:11
  19. Stent implantation into the tracheo-bronchial system may be life-saving in selected pediatric patients with otherwise intractable stenosis of the upper airways. Following implantation, significant tissue proli...

    Authors: Matthias Sigler, Julia Klötzer, Thomas Quentin, Thomas Paul and Oliver Möller
    Citation: Molecular and Cellular Pediatrics 2015 2:10
  20. Cystic fibrosis is a mono-genetic multi-system disease; however, respiratory manifestations cause the main morbidity and mortality where chronic bacterial infections lead to bronchiectasis and ultimately respi...

    Authors: Marianne S. Muhlebach and Wei Sha
    Citation: Molecular and Cellular Pediatrics 2015 2:9
  21. Authors: Christian Klemann, Arne Schröder, Anika Dreier, Nora Moehn, Stephanie Dippel, Thomas Winterberg, Anne Wilde, Yi Yu, Faikah Gueler, Anne Joerns, Eva Tolosa, Johannes Leonhardt, Jan D Haas, Immo Prinz, Claus Petersen and Joachim F Kuebler
    Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A21

    This article is part of a Supplement: Volume 2 Supplement 1