Articles
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Citation: Molecular and Cellular Pediatrics 2016 3:26
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Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease
Chronic lung disease remains the major cause of morbidity and mortality in patients with cystic fibrosis (CF). Recent studies in young children with CF diagnosed by newborn screening identified neutrophil elas...
Citation: Molecular and Cellular Pediatrics 2016 3:25 -
Early injury of the neonatal lung contributes to premature lung aging: a hypothesis
Chronic lung disease of the newborn, also known as bronchopulmonary dysplasia (BPD), is the most common chronic lung disease in early infancy and results in an increased risk for long-lasting pulmonary impairm...
Citation: Molecular and Cellular Pediatrics 2016 3:24 -
Pathogenesis of bronchopulmonary dysplasia: when inflammation meets organ development
Bronchopulmonary dysplasia is a chronic lung disease of preterm infants. It is caused by the disturbance of physiologic lung development mainly in the saccular stage with lifelong restrictions of pulmonary fun...
Citation: Molecular and Cellular Pediatrics 2016 3:23 -
Mendeliome sequencing enables differential diagnosis and treatment of neonatal lactic acidosis
Neonatal lactic acidosis can be associated to severe inborn errors of metabolism. Rapid identification of the underlying disorder may improve the clinical management through reliable counseling of the parents ...
Citation: Molecular and Cellular Pediatrics 2016 3:22 -
Mechanism of human rhinovirus infections
About 150 human rhinovirus serotypes are responsible for more than 50 % of recurrent upper respiratory infections. Despite having similar 3D structures, some bind members of the low-density lipoprotein recepto...
Citation: Molecular and Cellular Pediatrics 2016 3:21 -
The cross-talk between enterocytes and intraepithelial lymphocytes
The gut mucosa is continuously exposed to food and microbial antigens. Both enterocytes and intraepithelial lymphocytes have a pivotal role in maintaining the integrity of intestinal mucosa, as these cells gua...
Citation: Molecular and Cellular Pediatrics 2016 3:20 -
MicroRNA in late lung development and bronchopulmonary dysplasia: the need to demonstrate causality
MicroRNA are emerging as powerful regulators of cell differentiation and tissue and organ development. Several microRNA have been described to play a role in branching morphogenesis, a key step in early lung d...
Citation: Molecular and Cellular Pediatrics 2016 3:19 -
Mesenchymal stromal cells in the development and therapy of bronchopulmonary dysplasia
Bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, remains a major healthcare burden. Despite great progresses in perinatal medicine over the past decades, no cure for BPD has been foun...
Citation: Molecular and Cellular Pediatrics 2016 3:18 -
Alveologenesis: key cellular players and fibroblast growth factor 10 signaling
Alveologenesis is the last stage in lung development and is essential for building the gas-exchanging units called alveoli. Despite intensive lung research, the intricate crosstalk between mesenchymal and epit...
Citation: Molecular and Cellular Pediatrics 2016 3:17 -
Inhaled protein/peptide-based therapies for respiratory disease
Asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) are all chronic pulmonary diseases, albeit with different etiologies, that are characterized by airflow limitation, chronic inflam...
Citation: Molecular and Cellular Pediatrics 2016 3:16 -
Can the preterm lung recover from perinatal stress?
After birth, adequate lung function is necessary for the successful adaptation of a preterm baby. Both prenatal and postnatal insults and therapeutic interventions have an immediate effect on lung function and...
Citation: Molecular and Cellular Pediatrics 2016 3:15 -
The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens
The maintenance of oxygen homeostasis in human tissues is mediated by several cellular adaptations in response to low-oxygen stress, called hypoxia. A decrease in tissue oxygen levels is initially counteracted...
Citation: Molecular and Cellular Pediatrics 2016 3:14 -
Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis
Cystic fibrosis (CF) is a lethal monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that entails the (diagnostic) increase in sweat electrolyte concent...
Citation: Molecular and Cellular Pediatrics 2016 3:13 -
Update on host-pathogen interactions in cystic fibrosis lung disease
Bacterial and fungal infections are hallmarks of cystic fibrosis (CF) lung disease. In the era of long-term inhaled antibiotics and increasing CF patient survival, new “emerging” pathogens are detected in CF a...
Citation: Molecular and Cellular Pediatrics 2016 3:12 -
Underlying molecular and cellular mechanisms in childhood irritable bowel syndrome
Irritable bowel syndrome (IBS) affects a large number of children throughout the world. The symptom expression of IBS is heterogeneous, and several factors which may be interrelated within the IBS biopsychosoc...
Citation: Molecular and Cellular Pediatrics 2016 3:11 -
Fructose malabsorption
Incomplete intestinal absorption of fructose might lead to abdominal complaints such as pain, flatulence and diarrhoea. Whether defect fructose transporters such as GLUT5 or GLUT2 are involved in the pathogene...
Citation: Molecular and Cellular Pediatrics 2016 3:10 -
Diverse roles of endoplasmic reticulum stress sensors in bacterial infection
Bacterial infection often leads to cellular damage, primarily marked by loss of cellular integrity and cell death. However, in recent years, it is being increasingly recognized that, in individual cells, there...
Citation: Molecular and Cellular Pediatrics 2016 3:9 -
Endocytosis and transcytosis of gliadin peptides
Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Some gliadin peptides are not digested by intestinal proteases and can have diff...
Citation: Molecular and Cellular Pediatrics 2016 3:8 -
Genetics of irritable bowel syndrome
Irritable bowel syndrome (IBS) is a common condition with a complex and largely unknown etiology. There is no cure, and treatment options are mainly directed to the amelioration of symptoms. IBS causes reduced...
Citation: Molecular and Cellular Pediatrics 2016 3:7 -
Mesenchymal stem/stromal cells—a key mediator for regeneration after perinatal morbidity?
Perinatal complications in both term- and preterm-born infants are a leading cause of neonatal morbidities and mortality. Infants face different challenges in the neonatal intensive care unit with long-term mo...
Citation: Molecular and Cellular Pediatrics 2016 3:6 -
The clinical consequences of sucrase-isomaltase deficiency
Primary sucrase-isomaltase deficiency, originally thought to be a homozygous recessive disorder, has been found to have numerous genetic variants that alone or in combination (compound heterozygosity) express ...
Citation: Molecular and Cellular Pediatrics 2016 3:5 -
Milk glucosidase activity enables suckled pup starch digestion
Starch requires six enzymes for digestion to free glucose: two amylases (salivary and pancreatic) and four mucosal maltase activities; sucrase-isomaltase and maltase-glucoamylase. All are deficient in suckling...
Citation: Molecular and Cellular Pediatrics 2016 3:4 -
Towards understanding microvillus inclusion disease
Microvillus inclusion disease (MVID) is characterised by onset of intractable life-threatening watery diarrhoea during infancy. Transmission electron microscopy demonstrates shortening or absence of apical mic...
Citation: Molecular and Cellular Pediatrics 2016 3:3 -
The multiple roles of sucrase-isomaltase in the intestinal physiology
Osmotic diarrhea and abdominal pain in humans are oftentimes associated with carbohydrate malabsorption in the small intestine due to loss of function of microvillar disaccharidases. Disaccharidases are crucia...
Citation: Molecular and Cellular Pediatrics 2016 3:2 -
The role of hypoxia in intestinal inflammation
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the intestine. IBD is a multifactorial disorder, and IBD-associated genes are critical in innate immune response, inflammatory re...
Citation: Molecular and Cellular Pediatrics 2016 3:1 -
Expression and function of histamine and its receptors in atopic dermatitis
Atopic dermatitis constitutes a most burdensome chronic inflammatory skin disease. Standard treatment is cumbersome and often targets its main symptom, pruritus, only insufficiently.
Citation: Molecular and Cellular Pediatrics 2015 2:16 -
Pluripotent stem cells for disease modeling and drug screening: new perspectives for treatment of cystic fibrosis?
Despite continuous improvements in treating clinical symptoms and the identification of single compounds that effectively rescue some rare mutations in the cystic fibrosis transmembrane conductance regulator (...
Citation: Molecular and Cellular Pediatrics 2015 2:15 -
Post stroke hemi-dystonia in children: a neglected area of research
Childhood arterial ischemic stroke (CAIS) is increasingly recognized as an important cause of significant long-term morbidity in the pediatric population. Post stroke movement disorders, above all hemi-dystoni...
Citation: Molecular and Cellular Pediatrics 2015 2:14 -
Airway reactivity and sphingolipids—implications for childhood asthma
Asthma is a clinically heterogeneous disorder, whose onset and progression results from a complex interplay between genetic susceptibility, allergens, and viral triggers. Sphingolipids and altered sphingolipid...
Citation: Molecular and Cellular Pediatrics 2015 2:13 -
GM-CSF and the role of myeloid regulatory cells in the pathogenesis and treatment of Crohn’s disease
Intestinal monocytes/macrophages sustain the intestinal immune homeostasis and might be an attractive therapeutic target for the management of inflammatory bowel disease (IBD). Granulocyte macrophage colony-s...
Citation: Molecular and Cellular Pediatrics 2015 2:12 -
Modified mRNA as a new therapeutic option for pediatric respiratory diseases and hemoglobinopathies
The immunogenicity and limited stability of conventional messenger RNA (mRNA) has traditionally restricted its potential therapeutic use. In 1992, the first clinical application of mRNA was reported as a poten...
Citation: Molecular and Cellular Pediatrics 2015 2:11 -
Stent implantation into the tracheo-bronchial system in rabbits: histopathologic sequelae in bare metal vs. drug-eluting stents
Stent implantation into the tracheo-bronchial system may be life-saving in selected pediatric patients with otherwise intractable stenosis of the upper airways. Following implantation, significant tissue proli...
Citation: Molecular and Cellular Pediatrics 2015 2:10 -
Lessons learned from metabolomics in cystic fibrosis
Cystic fibrosis is a mono-genetic multi-system disease; however, respiratory manifestations cause the main morbidity and mortality where chronic bacterial infections lead to bronchiectasis and ultimately respi...
Citation: Molecular and Cellular Pediatrics 2015 2:9 -
Cilia-associated cellular function of the AAA ATPases RUVBL1 and RUVBL2
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A29 -
Simultaneously double infection of oncolytic viruses leads to addition of cell death induction in glioblastoma cell lines
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A28 -
A translational approach to dystroglycanopathies: a frequent type of muscular dystrophy
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A27 -
Fibrocystin in MDCK cells: impact on cell adhesion and epithelial morphogenesis
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A26 -
TMEM18 is a regulator of adipogenesis and involved in PPARG signalling in vivo
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A25 -
Neutralization of interleukin-17 produced by gamma delta T cells constrains inflammation in experimental biliary atresia
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A21 -
Regulation of PACAP receptors in respiratory distress syndrome (RDS) of preterms and newborns
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A19 -
Is the implementation of a microbiological surveillance screening beneficial in a neonatal intensive care unit?
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A17 -
Singleton-Merten Syndrome: a rare autoimmune disorder caused by a specific IFIH1 mutation
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A12 -
Neuroprotection after infection-sensitized neonatal hypoxic-ischemic brain injury
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A11 -
Integrated genomics elucidates relative spatial homogeneity of embryonal brain tumors
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A10 -
Mutations in the NKX2.1 and the PAX8 genes in a boy with thyroid dysgenesis, respiratory and neurological disorders
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A9 -
Nexilin mutations are associated with left ventricular noncompaction cardiomyopathy
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A7 -
Differential expression of mucosal trefoil factors and mucins in pediatric inflammatory bowel diseases
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A5 -
Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A3 -
Novel orphan medicines and abandoned pathways - the US Orphan Drug Act of 1983 and the impact on rare rheumatologic diseases and lysosomal storage disorders
Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A1
- ISSN: 2194-7791 (electronic)