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Molecular and Cellular Pediatrics
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  1. The postnatal intestinal colonization of human milk-fed and formula-fed infants differs substantially, as does the susceptibility to infectious diseases during infancy. Specific ingredients in human milk, such...

    Authors: Antonia Nomayo, Andreas Schwiertz, Rainer Rossi, Katharina Timme, Janine Foster, Richard Zelenka, Josef Tvrdik and Frank Jochum
    Citation: Molecular and Cellular Pediatrics 2020 7:6
    Content type: Research Published on:

  2. Febrile neutropenia is a common and serious complication during treatment of childhood cancer. Empirical broad-spectrum antibiotics are usually administered until neutrophil cell count recovery. It was the aim...

    Authors: Mira Siegmund, Julia Pagel, Tasja Scholz, Jan Rupp, Christoph Härtel and Melchior Lauten
    Citation: Molecular and Cellular Pediatrics 2020 7:5
    Content type: Research Published on:

  3. To ascertain interactions of caffeine ingestion, food, medications, and environmental exposures during preterm human gestation, under informed consent, we studied a cohort of Mexican women with further preterm...

    Authors: M. R. Alcorta-García, C. N. López-Villaseñor, G. Sánchez-Ferrer, H. Flores-Mendoza, F. Castorena-Torres, M. A. Aguilar-Torres, C. M. Sepúlveda-Treviño, J. A. Hernández-Hernández, R. C. López-Sánchez and V. J. Lara-Díaz
    Citation: Molecular and Cellular Pediatrics 2020 7:4
    Content type: Research Published on:

  4. Optoacoustic imaging (OAI), or photoacoustic imaging (PAI), has fundamentally influenced basic science by providing high-resolution visualization of biological mechanisms. With the introduction of multispectra...

    Authors: Adrian P. Regensburger, Alexandra L. Wagner, Jing Claussen, Maximilian J. Waldner and Ferdinand Knieling
    Citation: Molecular and Cellular Pediatrics 2020 7:3
    Content type: Mini review Published on:

  5. X chromosome inactivation (XCI) is an indispensable process in the development of human female embryos. Reportedly, XCI occurs when a blastocyst contains 10–12 embryonic progenitor cells. To date, it remains u...

    Authors: Kenichi Kinjo, Tomoko Yoshida, Yoshitomo Kobori, Hiroshi Okada, Erina Suzuki, Tsutomu Ogata, Mami Miyado and Maki Fukami
    Citation: Molecular and Cellular Pediatrics 2020 7:1
    Content type: Short Communication Published on:

  6. The impairment of nephrogenesis is caused by noxae, all of which are significantly different in molecular composition. These can cause an early termination of nephron development in preterm and low birth weigh...

    Authors: Will W. Minuth
    Citation: Molecular and Cellular Pediatrics 2020 7:2
    Content type: Research Published on:

  8. In Western countries, vegetarian diets are associated with lower intakes of energy, saturated fatty acids and animal protein and higher intakes of fibre and phytochemicals, compared to omnivorous diets. Whethe...

    Authors: Silvia Rudloff, Christoph Bührer, Frank Jochum, Thomas Kauth, Mathilde Kersting, Antje Körner, Berthold Koletzko, Walter Mihatsch, Christine Prell, Thomas Reinehr and Klaus-Peter Zimmer
    Citation: Molecular and Cellular Pediatrics 2019 6:4
    Content type: Consensus Paper Published on:

  9. Low vitamin D serum concentrations have been associated with rickets and other disorders in observational studies. Since vitamin D serum concentrations in children and adolescents are frequently below referenc...

    Authors: Thomas Reinehr, Dirk Schnabel, Martin Wabitsch, Susanne Bechtold-Dalla Pozza, Christoph Bührer, Bettina Heidtmann, Frank Jochum, Thomas Kauth, Antje Körner, Walter Mihatsch, Christine Prell, Silvia Rudloff, Bettina Tittel, Joachim Woelfle, Klaus-Peter Zimmer and Berthold Koletzko
    Citation: Molecular and Cellular Pediatrics 2019 6:3
    Content type: Consensus Paper Published on:

  10. Pureed complementary feeding products packed in squeezable plastic pouches, usually with a spout and a screw cap, have been increasingly marketed. The Committee on Nutrition recommends that infants and young c...

    Authors: Berthold Koletzko, Christoph Bührer, Regina Ensenauer, Frank Jochum, Hermann Kalhoff, Burkhard Lawrenz, Antje Körner, Walter Mihatsch, Silvia Rudloff and Klaus-Peter Zimmer
    Citation: Molecular and Cellular Pediatrics 2019 6:2
    Content type: Consensus Paper Published on:

  11. Birth cohort studies can contribute substantially to the understanding of health and disease — in childhood and over the life course. The KUNO-Kids birth cohort study was established to investigate various asp...

    Authors: Susanne Brandstetter, Antoaneta A. Toncheva, Jakob Niggel, Christine Wolff, Silvia Gran, Birgit Seelbach-Göbel, Christian Apfelbacher, Michael Melter and Michael Kabesch
    Citation: Molecular and Cellular Pediatrics 2019 6:1
    Content type: Research Published on:

  12. β-Thalassemia is an inherited hematological disorder caused by mutations in the human hemoglobin beta (HBB) gene that reduce or abrogate β-globin expression. Although lentiviral-mediated expression of β-globin an...

    Authors: Justin S. Antony, Ngadhnjim Latifi, A. K. M. Ashiqul Haque, Andrés Lamsfus-Calle, Alberto Daniel-Moreno, Sebastian Graeter, Praveen Baskaran, Petra Weinmann, Markus Mezger, Rupert Handgretinger and Michael S. D. Kormann
    Citation: Molecular and Cellular Pediatrics 2018 5:9
    Content type: Short Communication Published on:

  13. Survival rates of children with cancer are steadily increasing. This urges our attention to neurocognitive and psychiatric outcomes, as these can markedly influence the quality of life of these children. Neuro...

    Authors: Chrysanthy Ikonomidou
    Citation: Molecular and Cellular Pediatrics 2018 5:8
    Content type: Mini review Published on:

  15. Outcome in treatment of childhood cancers has improved dramatically since the 1970s. This success was largely achieved by the implementation of cooperative clinical research trial groups that standardized and ...

    Authors: Stefan E. G. Burdach, Mike-Andrew Westhoff, Maximilian Felix Steinhauser and Klaus-Michael Debatin
    Citation: Molecular and Cellular Pediatrics 2018 5:6
    Content type: Review Published on:

  18. Antisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target a...

    Authors: Kelly M. Martinovich, Nicole C. Shaw, Anthony Kicic, André Schultz, Sue Fletcher, Steve D. Wilton and Stephen M. Stick
    Citation: Molecular and Cellular Pediatrics 2018 5:3
    Content type: Review Published on:

  19. Impaired regulatory T cell immunity plays a central role in the development of type 1 diabetes (T1D). Interleukin-2 receptor (IL-2R) signaling is essential for regulatory T cells (TREG), and cytokine-inducible SH...

    Authors: Julia Seyfarth, Heinz Ahlert, Joachim Rosenbauer, Christina Baechle, Michael Roden, Reinhard W. Holl, Ertan Mayatepek, Thomas Meissner and Marc Jacobsen
    Citation: Molecular and Cellular Pediatrics 2018 5:2
    Content type: Research Published on:

  20. Children with inflammatory bowel disease (IBD) or autoimmune hepatitis (AIH) are at risk for severe infections. This is partially a result of their chronic disease condition but, moreover, a side effect of the...

    Authors: Teresa Schleker, Eva-Maria Jacobsen, Benjamin Mayer, Gudrun Strauss, Klaus-Michael Debatin and Carsten Posovszky
    Citation: Molecular and Cellular Pediatrics 2018 5:1
    Content type: Research Published on:

  21. Numerous investigations are dealing with anlage of the mammalian kidney and primary development of nephrons. However, only few information is available about the last steps in kidney development leading at bir...

    Authors: Will W. Minuth
    Citation: Molecular and Cellular Pediatrics 2017 4:12
    Content type: Review Published on:

  23. Mutations in the leptin gene (LEP) can alter the secretion or interaction of leptin with its receptor, leading to extreme early-onset obesity. The purpose of this work was to estimate the prevalence of heteroz...

    Authors: Adriana Nunziata, Guntram Borck, Jan-Bernd Funcke, Katja Kohlsdorf, Stephanie Brandt, Anke Hinney, Barbara Moepps, Peter Gierschik, Klaus-Michael Debatin, Pamela Fischer-Posovszky and Martin Wabitsch
    Citation: Molecular and Cellular Pediatrics 2017 4:10
    Content type: Research Published on:

  24. Transcatheter closure has become the treatment of choice for secundum atrial septal defects (ASD II), but particularly in small children, there is concern regarding procedure-related complications.

    Authors: Roman Scheidmann, Thomas Paul and Matthias Sigler
    Citation: Molecular and Cellular Pediatrics 2017 4:9
    Content type: Case Study Published on:

  25. Autism spectrum disorders (ASDs) are neurodevelopmental disorders with impaired social interactions and communication and restrictive, repetitive patterns of behaviors, interests, and activities. A recent epid...

    Authors: Michaela Kuhlen, Julia Taeubner, Dagmar Wieczorek and Arndt Borkhardt
    Citation: Molecular and Cellular Pediatrics 2017 4:8
    Content type: Short Communication Published on:

  26. Chronic non-bacterial osteomyelitis (CNO) belongs to the growing spectrum of autoinflammatory diseases and primarily affects the skeletal system. Peak onset ranges between 7 and 12 years of age. The clinical s...

    Authors: Sigrun Ruth Hofmann, Franz Kapplusch, Katrin Mäbert and Christian Michael Hedrich
    Citation: Molecular and Cellular Pediatrics 2017 4:7
    Content type: Mini review Published on:

  27. Precursor B acute lymphoblastic leukemia (BCP-ALL), the most common childhood malignancy, arises from an expansion of malignant B cell precursors in the bone marrow. Epidemiological studies suggest that infect...

    Authors: Simone Bürgler and David Nadal
    Citation: Molecular and Cellular Pediatrics 2017 4:6
    Content type: Review Published on:

  28. Authors: Rhea van den Bruck, Patrick P. Weil, Thomas Ziegenhals, Philipp Schreiner, Stefan Juranek, Daniel Gödde, Silvia Vogel, Frauke Schuster, Valerie Orth, Johannes Dörner, Daniel Pembaur, Meike Röper, Stefan Störkel, Hubert Zirngibl, Stefan Wirth, Andreas C. W. Jenke…
    Citation: Molecular and Cellular Pediatrics 2017 4(Suppl 1):5
    Content type: Meeting abstracts Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  29. The intrauterine environment was long considered sterile. However, several infectious threats are already present during fetal life. This review focuses on the postnatal immunological consequences of prenatal ...

    Authors: Gijs T. J. van Well, Leonie A. Daalderop, Tim Wolfs and Boris W. Kramer
    Citation: Molecular and Cellular Pediatrics 2017 4:4
    Content type: Review Published on:

  30. Exposure to second-hand tobacco smoke (SHS) is one of the prime risk factors for chronic lung disease development. Smoking during pregnancy may lead to birth defects in the newborn that include pulmonary dysfu...

    Authors: Neel Patel, Christopher D. Trumph, Manish Bodas and Neeraj Vij
    Citation: Molecular and Cellular Pediatrics 2017 4:3
    Content type: Short Communication Published on:

  31. The developmental origin of health and disease concept identifies the brain, cardiovascular, liver, and kidney systems as targets of fetal adverse programming with adult consequences. As the limits of viabilit...

    Authors: Amelie Stritzke, Sumesh Thomas, Harish Amin, Christoph Fusch and Abhay Lodha
    Citation: Molecular and Cellular Pediatrics 2017 4:2
    Content type: Review Published on:

  33. The pathological course of several chronic inflammatory diseases, including cystic fibrosis, chronic obstructive pulmonary disease, and rheumatoid arthritis, features an aberrant innate immune response dominat...

    Authors: Camilla Margaroli and Rabindra Tirouvanziam
    Citation: Molecular and Cellular Pediatrics 2016 3:38
    Content type: Review Published on:

  34. Rett syndrome is best known due to its severe and devastating symptoms in the central nervous system. It is produced by mutations affecting the Mecp2 gene that codes for a transcription factor. Nevertheless, evid...

    Authors: Pamela Millar-Büchner, Amber R. Philp, Noemí Gutierrez, Sandra Villanueva, Bredford Kerr and Carlos A. Flores
    Citation: Molecular and Cellular Pediatrics 2016 3:37
    Content type: Research Published on:

  35. Wilms’ tumor is an embryonal neoplasm of the kidney that accounts for approximately 6 % of all childhood tumors. The chemokine CXCL12 (C-X-C chemokine ligand 12) and its ligand CXCR4 (C-X-C chemokine receptor ...

    Authors: Patricia Midori Murobushi Ozawa, Carolina Batista Ariza, Roberta Losi-Guembarovski, Alda Losi Guembarovski, Carlos Eduardo Coral de Oliveira, Bruna Karina Banin-Hirata, Marina Okuyama Kishima, Diego Lima Petenuci and Maria Angelica Ehara Watanabe
    Citation: Molecular and Cellular Pediatrics 2016 3:36
    Content type: Research Published on:

  36. Impaired cellular innate immune defense accounts for susceptibility to sepsis and its high morbidity and mortality in preterm infants. Leukocyte recruitment is an integral part of the cellular immune response ...

    Authors: Katinka Karenberg, Hannes Hudalla and David Frommhold
    Citation: Molecular and Cellular Pediatrics 2016 3:35
    Content type: Mini review Published on:

  37. Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due...

    Authors: Chiharu Ota, Hoeke A. Baarsma, Darcy E. Wagner, Anne Hilgendorff and Melanie Königshoff
    Citation: Molecular and Cellular Pediatrics 2016 3:34
    Content type: Review Published on:

  38. Neonatal leukemia is a rare disease with an estimated prevalence of about one to five in a million neonates. The majority being acute myeloid leukemia (AML), neonatal leukemia can present with a variety of sym...

    Authors: Tobias Gyárfás, Juergen Wintgens, Wolfgang Biskup, Ilske Oschlies, Wolfram Klapper, Reiner Siebert, Susanne Bens, Claudia Haferlach, Roland Meisel, Michaela Kuhlen and Arndt Borkhardt
    Citation: Molecular and Cellular Pediatrics 2016 3:30
    Content type: Short Communication Published on:

  39. Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limited recurrent attacks of fever and serositis. Patients may develop renal amyloidosis. Colchicine prevents attacks ...

    Authors: Betul Sozeri, Nesrin Gulez, Malik Ergin and Erkin Serdaroglu
    Citation: Molecular and Cellular Pediatrics 2016 3:33
    Content type: Case Study Published on:

  41. Asthma is the most common chronic disease starting in childhood and persisting into adulthood in many cases. During childhood, different forms of asthma and wheezing disorders exist that can be discriminated b...

    Authors: Michael Kabesch
    Citation: Molecular and Cellular Pediatrics 2016 3:31
    Content type: Mini review Published on:

  42. Influenza viruses (IVs) circulate seasonally and are a common cause of respiratory infections in pediatric and adult patients. Additionally, recurrent pandemics cause massive morbidity and mortality worldwide....

    Authors: Barbara Rösler and Susanne Herold
    Citation: Molecular and Cellular Pediatrics 2016 3:29
    Content type: Mini review Published on:

  43. Retinoic acid (RA), the active form of vitamin A, regulates key developmental processes in multiple organs. In the developing lung, RA is crucial for normal growth and differentiation of airways. Disruption in...

    Authors: Hector A. Marquez and Wellington V. Cardoso
    Citation: Molecular and Cellular Pediatrics 2016 3:28
    Content type: Mini review Published on:

  44. Asthma represents the most common chronic childhood disease worldwide. Whereas preschool children present with wheezing triggered by different factors (multitrigger and viral wheeze), clinical asthma manifesta...

    Authors: Katja Landgraf-Rauf, Bettina Anselm and Bianca Schaub
    Citation: Molecular and Cellular Pediatrics 2016 3:27
    Content type: Mini review Published on:

  48. Bronchopulmonary dysplasia is a chronic lung disease of preterm infants. It is caused by the disturbance of physiologic lung development mainly in the saccular stage with lifelong restrictions of pulmonary fun...

    Authors: Tayyab Shahzad, Sarah Radajewski, Cho-Ming Chao, Saverio Bellusci and Harald Ehrhardt
    Citation: Molecular and Cellular Pediatrics 2016 3:23
    Content type: Mini review Published on:

  49. Neonatal lactic acidosis can be associated to severe inborn errors of metabolism. Rapid identification of the underlying disorder may improve the clinical management through reliable counseling of the parents ...

    Authors: Walid Fazeli, Mert Karakaya, Peter Herkenrath, Anne Vierzig, Jörg Dötsch, Jürgen-Christoph von Kleist-Retzow and Sebahattin Cirak
    Citation: Molecular and Cellular Pediatrics 2016 3:22
    Content type: Research Published on:

  50. The gut mucosa is continuously exposed to food and microbial antigens. Both enterocytes and intraepithelial lymphocytes have a pivotal role in maintaining the integrity of intestinal mucosa, as these cells gua...

    Authors: Serena Vitale, Stefania Picascia and Carmen Gianfrani
    Citation: Molecular and Cellular Pediatrics 2016 3:20
    Content type: Mini review Published on:
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