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  1. Mini review

    Mechanism of human rhinovirus infections

    About 150 human rhinovirus serotypes are responsible for more than 50 % of recurrent upper respiratory infections. Despite having similar 3D structures, some bind members of the low-density lipoprotein recepto...

    Dieter Blaas and Renate Fuchs

    Molecular and Cellular Pediatrics 2016 3:21

    Published on: 1 June 2016

  2. Mini review

    The cross-talk between enterocytes and intraepithelial lymphocytes

    The gut mucosa is continuously exposed to food and microbial antigens. Both enterocytes and intraepithelial lymphocytes have a pivotal role in maintaining the integrity of intestinal mucosa, as these cells gua...

    Serena Vitale, Stefania Picascia and Carmen Gianfrani

    Molecular and Cellular Pediatrics 2016 3:20

    Published on: 1 June 2016

  3. Mini review

    Alveologenesis: key cellular players and fibroblast growth factor 10 signaling

    Alveologenesis is the last stage in lung development and is essential for building the gas-exchanging units called alveoli. Despite intensive lung research, the intricate crosstalk between mesenchymal and epit...

    Cho-Ming Chao, Alena Moiseenko, Klaus-Peter Zimmer and Saverio Bellusci

    Molecular and Cellular Pediatrics 2016 3:17

    Published on: 21 April 2016

  4. Review

    Inhaled protein/peptide-based therapies for respiratory disease

    Asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) are all chronic pulmonary diseases, albeit with different etiologies, that are characterized by airflow limitation, chronic inflam...

    Robert C. Fellner, Shawn T. Terryah and Robert Tarran

    Molecular and Cellular Pediatrics 2016 3:16

    Published on: 20 April 2016

  5. Mini review

    Can the preterm lung recover from perinatal stress?

    After birth, adequate lung function is necessary for the successful adaptation of a preterm baby. Both prenatal and postnatal insults and therapeutic interventions have an immediate effect on lung function and...

    Matthias C. Hütten, Tim G. A. M. Wolfs and Boris W. Kramer

    Molecular and Cellular Pediatrics 2016 3:15

    Published on: 13 April 2016

  6. Mini review

    The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens

    The maintenance of oxygen homeostasis in human tissues is mediated by several cellular adaptations in response to low-oxygen stress, called hypoxia. A decrease in tissue oxygen levels is initially counteracted...

    Nathalie E. Zeitouni, Sucheera Chotikatum, Maren von Köckritz-Blickwede and Hassan Y. Naim

    Molecular and Cellular Pediatrics 2016 3:14

    Published on: 22 March 2016

  7. Mini review

    Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis

    Cystic fibrosis (CF) is a lethal monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that entails the (diagnostic) increase in sweat electrolyte concent...

    Speranza Esposito, Antonella Tosco, Valeria R. Villella, Valeria Raia, Guido Kroemer and Luigi Maiuri

    Molecular and Cellular Pediatrics 2016 3:13

    Published on: 14 March 2016

  8. Mini review

    Update on host-pathogen interactions in cystic fibrosis lung disease

    Bacterial and fungal infections are hallmarks of cystic fibrosis (CF) lung disease. In the era of long-term inhaled antibiotics and increasing CF patient survival, new “emerging” pathogens are detected in CF a...

    Andreas Hector, Nina Frey and Dominik Hartl

    Molecular and Cellular Pediatrics 2016 3:12

    Published on: 23 February 2016

  9. Mini review

    Fructose malabsorption

    Incomplete intestinal absorption of fructose might lead to abdominal complaints such as pain, flatulence and diarrhoea. Whether defect fructose transporters such as GLUT5 or GLUT2 are involved in the pathogene...

    Karolin Ebert and Heiko Witt

    Molecular and Cellular Pediatrics 2016 3:10

    Published on: 16 February 2016

  10. Mini review

    Endocytosis and transcytosis of gliadin peptides

    Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Some gliadin peptides are not digested by intestinal proteases and can have diff...

    M. Vittoria Barone and K. Peter Zimmer

    Molecular and Cellular Pediatrics 2016 3:8

    Published on: 16 February 2016

  11. Mini review

    Diverse roles of endoplasmic reticulum stress sensors in bacterial infection

    Bacterial infection often leads to cellular damage, primarily marked by loss of cellular integrity and cell death. However, in recent years, it is being increasingly recognized that, in individual cells, there...

    Helena Pillich, Maria Loose, Klaus-Peter Zimmer and Trinad Chakraborty

    Molecular and Cellular Pediatrics 2016 3:9

    Published on: 16 February 2016

  12. Mini review

    Genetics of irritable bowel syndrome

    Irritable bowel syndrome (IBS) is a common condition with a complex and largely unknown etiology. There is no cure, and treatment options are mainly directed to the amelioration of symptoms. IBS causes reduced...

    Maria Henström and Mauro D’Amato

    Molecular and Cellular Pediatrics 2016 3:7

    Published on: 12 February 2016

  13. Mini review

    Mesenchymal stem/stromal cells—a key mediator for regeneration after perinatal morbidity?

    Perinatal complications in both term- and preterm-born infants are a leading cause of neonatal morbidities and mortality. Infants face different challenges in the neonatal intensive care unit with long-term mo...

    Martin Mueller, Tim G. A. Wolfs, Andreina Schoeberlein, Antonio W. D. Gavilanes, Daniel Surbek and Boris W. Kramer

    Molecular and Cellular Pediatrics 2016 3:6

    Published on: 11 February 2016

  14. Mini review

    The clinical consequences of sucrase-isomaltase deficiency

    Primary sucrase-isomaltase deficiency, originally thought to be a homozygous recessive disorder, has been found to have numerous genetic variants that alone or in combination (compound heterozygosity) express ...

    Stanley A. Cohen

    Molecular and Cellular Pediatrics 2016 3:5

    Published on: 8 February 2016

  15. Mini review

    Milk glucosidase activity enables suckled pup starch digestion

    Starch requires six enzymes for digestion to free glucose: two amylases (salivary and pancreatic) and four mucosal maltase activities; sucrase-isomaltase and maltase-glucoamylase. All are deficient in suckling...

    B. L. Nichols, M. Diaz-Sotomayor, S. E. Avery, S. K. Chacko, D. L. Hadsell, S. S. Baker, B. R. Hamaker, L. K. Yan, H. M. Lin and R. Quezada-Calvillo

    Molecular and Cellular Pediatrics 2016 3:4

    Published on: 1 February 2016

  16. Mini review

    Towards understanding microvillus inclusion disease

    Microvillus inclusion disease (MVID) is characterised by onset of intractable life-threatening watery diarrhoea during infancy. Transmission electron microscopy demonstrates shortening or absence of apical mic...

    Georg F. Vogel, Michael W. Hess, Kristian Pfaller, Lukas A. Huber, Andreas R. Janecke and Thomas Müller

    Molecular and Cellular Pediatrics 2016 3:3

    Published on: 29 January 2016

  17. Mini review

    The multiple roles of sucrase-isomaltase in the intestinal physiology

    Osmotic diarrhea and abdominal pain in humans are oftentimes associated with carbohydrate malabsorption in the small intestine due to loss of function of microvillar disaccharidases. Disaccharidases are crucia...

    Birthe Gericke, Mahdi Amiri and Hassan Y. Naim

    Molecular and Cellular Pediatrics 2016 3:2

    Published on: 26 January 2016

  18. Mini review

    The role of hypoxia in intestinal inflammation

    Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the intestine. IBD is a multifactorial disorder, and IBD-associated genes are critical in innate immune response, inflammatory re...

    Yatrik M. Shah

    Molecular and Cellular Pediatrics 2016 3:1

    Published on: 26 January 2016

  19. Minireview

    Post stroke hemi-dystonia in children: a neglected area of research

    Childhood arterial ischemic stroke (CAIS) is increasingly recognized as an important cause of significant long-term morbidity in the pediatric population. Post stroke movement disorders, above all hemi-dystoni...

    Daniel Tibussek, Ertan Mayatepek, Dirk Klee and Anne Koy

    Molecular and Cellular Pediatrics 2015 2:14

    Published on: 11 December 2015

  20. Review

    Airway reactivity and sphingolipids—implications for childhood asthma

    Asthma is a clinically heterogeneous disorder, whose onset and progression results from a complex interplay between genetic susceptibility, allergens, and viral triggers. Sphingolipids and altered sphingolipid...

    Jennie G. Ono, Tilla S. Worgall and Stefan Worgall

    Molecular and Cellular Pediatrics 2015 2:13

    Published on: 4 December 2015

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