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  1. The immunogenicity and limited stability of conventional messenger RNA (mRNA) has traditionally restricted its potential therapeutic use. In 1992, the first clinical application of mRNA was reported as a poten...

    Authors: Justin S. Antony, Alexander Dewerth, Ashiqul Haque, Rupert Handgretinger and Michael S.D. Kormann
    Citation: Molecular and Cellular Pediatrics 2015 2:11
  2. Stent implantation into the tracheo-bronchial system may be life-saving in selected pediatric patients with otherwise intractable stenosis of the upper airways. Following implantation, significant tissue proli...

    Authors: Matthias Sigler, Julia Klötzer, Thomas Quentin, Thomas Paul and Oliver Möller
    Citation: Molecular and Cellular Pediatrics 2015 2:10
  3. Cystic fibrosis is a mono-genetic multi-system disease; however, respiratory manifestations cause the main morbidity and mortality where chronic bacterial infections lead to bronchiectasis and ultimately respi...

    Authors: Marianne S. Muhlebach and Wei Sha
    Citation: Molecular and Cellular Pediatrics 2015 2:9
  4. Authors: Miguel A Alejandre Alcazar, Mark Kaschwich, Stefanie Preuss, Robert Ertsey, Sana Mujahid, Eva Rother, Katharina Dinger, Jörg Dötsch, Marlene Rabinovitch and Richard Bland
    Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A30

    This article is part of a Supplement: Volume 2 Supplement 1

  5. Authors: AleÅ¡ Janda, Klaus Schwarz, Mirjam van der Burg, Werner Vach, Hanna Ijspeert, Myriam Ricarda Lorenz, Magdeldin Elgizouli, Kathrin Pieper, Paul Fisch, Joachim Hagel, Raquel Lorenzetti, Maximilian Seidl, Joachim Roesler, Fabian Hauck, Elisabetta Traggiai, Carsten Speckmann…
    Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A23

    This article is part of a Supplement: Volume 2 Supplement 1

  6. Authors: Christian Klemann, Arne Schröder, Anika Dreier, Nora Moehn, Stephanie Dippel, Thomas Winterberg, Anne Wilde, Yi Yu, Faikah Gueler, Anne Joerns, Eva Tolosa, Johannes Leonhardt, Jan D Haas, Immo Prinz, Claus Petersen and Joachim F Kuebler
    Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A21

    This article is part of a Supplement: Volume 2 Supplement 1

  7. Authors: J Wallmeier, M Boon, D Al Mutairi, NT Loges, L Ma, C-T Chen, H Olbrich, P Pennekamp, T Menchen, G Dougherty, C Werner, M Jaspers, M Griese, E Horak, C Körner-Rettberg, S Schmitt-Grohé…
    Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A15

    This article is part of a Supplement: Volume 2 Supplement 1

  8. Authors: Johannes Fabian, Desirée Opitz, Kristina Althoff, Marco Lodrini, Kathy Astrahantseff, Barbara Hero, Ruth Volland, Anneleen Beckers, Katleen de Preter, Nitin S Patil, Mohammed L Abba, Theresa M Thole, Jasmin Wünschel, Annette Künkele, Jamie Hu, Leonille Schweizer…
    Citation: Molecular and Cellular Pediatrics 2015 2(Suppl 1):A13

    This article is part of a Supplement: Volume 2 Supplement 1

  9. Childhood obesity and incidence of asthma are increasing globally. The parallel increase of the two suggests that obesity and asthma may be related and that abnormalities in the lipid and/or glucose metabolism...

    Authors: Hartmut Grasemann
    Citation: Molecular and Cellular Pediatrics 2015 2:6
  10. Sodium channels predominantly expressed in brain are expressed in myocardial tissue and play an important role in cardiac physiology. Alterations of sodium channels are known to result in neurological disease ...

    Authors: Ulrich Krause, Christian Alflen, Michael Steinmetz, Matthias J Müller, Thomas Quentin and Thomas Paul
    Citation: Molecular and Cellular Pediatrics 2015 2:5
  11. Term and near-term infants are at high risk of developing brain injury and life-long disability if they have suffered from severe perinatal asphyxia. We hypothesized that propofol administration to the materna...

    Authors: Matthias Seehase, Ward Jennekens, Alex Zwanenburg, Peter Andriessen, Jennifer JP Collins, Elke Kuypers, Luc J Zimmermann, Johan SH Vles, Antonio WD Gavilanes and Boris W Kramer
    Citation: Molecular and Cellular Pediatrics 2015 2:4
  12. Chitin, after cellulose, the second most abundant biopolymer on earth, is a key component of insects, fungi, and house-dust mites. Lower life forms are endowed with chitinases to defend themselves against chit...

    Authors: Ines Mack, Andreas Hector, Marlene Ballbach, Julius Kohlhäufl, Katharina J Fuchs, Alexander Weber, Marcus A Mall and Dominik Hartl
    Citation: Molecular and Cellular Pediatrics 2015 2:3
  13. MicroRNA (miRNA) and messenger RNA (mRNA) expression differs in cystic fibrosis (CF) versus non-CF bronchial epithelium. Here, the role of miRNA in basal regulation of the transcription factor ATF6 was investi...

    Authors: Irene K Oglesby, Raman Agrawal, Marcus A Mall, Noel G McElvaney and Catherine M Greene
    Citation: Molecular and Cellular Pediatrics 2015 2:1
  14. Protein homeostasis describes the tight supervision of protein synthesis, correct protein maturation and folding, as well as the timely disposal of unwanted and damaged proteins by the ubiquitin-proteasome pat...

    Authors: Silke Meiners and Korbinian Ballweg
    Citation: Molecular and Cellular Pediatrics 2014 1:11
  15. Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia. However, despite our clinical and ...

    Authors: Katharina Rose Luise Schmitt, Giang Tong and Felix Berger
    Citation: Molecular and Cellular Pediatrics 2014 1:7
  16. Matrix metalloproteinases are vital drivers of synaptic remodeling in health and disease. It is suggested that at early stages of epileptogenesis, inhibition of matrix metalloproteinases may help ameliorate ce...

    Authors: Chrysanthy Ikonomidou
    Citation: Molecular and Cellular Pediatrics 2014 1:6
  17. Most cancer therapies are devised for adult or even elder patients. However, when dealing with pediatric cancers, additional considerations are needed.

    Authors: Mike-Andrew Westhoff, Oliver Brühl and Klaus-Michael Debatin
    Citation: Molecular and Cellular Pediatrics 2014 1:10
  18. MicroRNAs (miRNAs) are crucial regulators of human immunity e.g. against Mycobacterium tuberculosis. Against the background of still alarming high mortality of tuberculosis effective biomarkers to improve diagnos...

    Authors: Bianca Ueberberg, Malte Kohns, Ertan Mayatepek and Marc Jacobsen
    Citation: Molecular and Cellular Pediatrics 2014 1:8
  19. Deficiency of very long-chain acyl-CoA dehydrogenase (VLCAD) is the most common disorder of mitochondrial β-oxidation of long-chain fatty acids. In order to maintain glucose homeostasis, the kidney and liver a...

    Authors: Sara Tucci, Antonia Krogmann, Diran Herebian and Ute Spiekerkoetter
    Citation: Molecular and Cellular Pediatrics 2014 1:5