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Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia. However, despite our clinical and ...
Matrix metalloproteinases are vital drivers of synaptic remodeling in health and disease. It is suggested that at early stages of epileptogenesis, inhibition of matrix metalloproteinases may help ameliorate ce...
Fanconi anemia is one of the best studied inherited cancer-prone diseases. Greatly improved protocols for hematopoietic stem cell transplantation increasingly save the lives of these young patients. However, i...
Most cancer therapies are devised for adult or even elder patients. However, when dealing with pediatric cancers, additional considerations are needed.
MicroRNAs (miRNAs) are crucial regulators of human immunity e.g. against Mycobacterium tuberculosis. Against the background of still alarming high mortality of tuberculosis effective biomarkers to improve diagnos...
Deficiency of very long-chain acyl-CoA dehydrogenase (VLCAD) is the most common disorder of mitochondrial β-oxidation of long-chain fatty acids. In order to maintain glucose homeostasis, the kidney and liver a...
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
No abstract.
Congenital leptin deficiency is a rare autosomal recessive monogenic obesity syndrome caused by mutations in the leptin gene. This review describes the molecular and cellular characteristics of the eight disti...
Perinatal programming, i.e., the (epigenetic) modification of (genetic) functions throughout lifetime, suffers from the notion of premature theories and difficult and extensive research strategies.
Fragile X is the most common form of inherited intellectual disability and the leading known genetic cause of autism. There is currently no cure or approved medication for fragile X although various drugs targ...
