Association of immune cell recruitment and BPD development

Heydarian, Motaharehsadat; Schulz, Christian; Stoeger, Tobias; Hilgendorff, Anne

doi:10.1186/s40348-022-00148-w

Molecular and Cellular Pediatrics

Table 1 Selected research on the role of neutrophils and monocytes in BPD

From: Association of immune cell recruitment and BPD development

Year	Model/specimen	Main findings on the role of neutrophils and monocytes in BPD	Ref
1984	Human neonatal BAL	Neutrophil influx and imbalance between elastase and alpha 1-proteinase inhibitor contribute to BPD development.	[134]
2001	Human neonatal TA	MCP-1 and IL-8 increase describes BPD and is correlated to oxygen exposure and duration of MV.	[135]
2003	Fetal and neonatal lamb	Monocytes from preterm and term lambs differ from the adult cells regarding inflammation initiation and resolution.	[124]
2004	Human neonatal cells	Decreased CD18 expression on neutrophils and monocytes and CD62L on neutrophils are early predictors of BPD.	[76]
2004	Neonatal rat	The combination of hyperoxia exposure and neutrophil accumulation has a pivotal role in the development of BPD.	[67]
2007	Human placenta and cord blood	Neonatal monocytic IL-10 production is below the needed for inhibition of release of IL-8. Suggesting exogenous IL-10 as a BPD treatment strategy.	[136]
2008	Human neonatal blood	Low neutrophil counts in the systemic circulation might predict BPD severity.	[142]
2009	Neonatal sheep	Prenatal inflammation affects fetal immune responses including the maturation of monocytes to AMs.	[13]
2011	Neonatal mice	MV-O₂ leads to an increased accumulation of neutrophils and monocytes/macrophages in the lung.	[143]
2013	Neonatal mice	Perinatal inflammation and postnatal hyperoxia mark the activation of the macrophages which can be enhanced by IL-1Ra.	[144]
2015	Neonatal mice	Increased TGFβ1 expression in leads to apoptosis and monocyte and macrophage infiltration.	[145]
2016	Neonatal mice	MV increases the infiltrating monocytes and cytokine expression in the lungs of TNFα^-/- mice in comparison to the WT.	[138]
2018	Neonatal mice	Csf1r expressing monocyte/macrophage lineage are critical mediators of arrested alveolarization.	[83]
2019	Human neonatal blood	The elevated neutrophil-to-lymphocyte ratio is an early predictor of BPD.	[12]
2019	Neonatal mice and human neonatal TA	The presence of neutrophil-derived pathogenic in BPD lung secretion promotes extracellular matrix destruction.	[66]
2019	Human neonatal TA	Association between early changes in monocyte-specific IL-1 cytokine and evolving BPD.	[24]
2019	Neonatal mice and human neonatal TA	Inhibition of miR199a-5p improves lung vascular leak and decreased BALF total cell counts including macrophages and neutrophil influx.	[146]
2020	Neonatal rat	Long-term hyperoxia exposure reduced the number of peripheral blood neutrophils in BPD.	[77]
2020	Human neonatal TA	Identify higher expression of inflammatory mediator genes on the first day of life as a predictive BPD signature.	[123]
2021	Neonatal rat	Upregulated monocyte and neutrophil chemotaxis genes and involvement of the pulmonary T cell receptor signaling pathway in BPD.	[147]

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