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Table 1 Basic demographic and clinical data of the study population. Significant values are highlighted

From: DMBT1 expression and neutrophil-to-lymphocyte ratio during necrotizing enterocolitis are influenced by impaired perfusion due to cardiac anomalies

Clinical parameter Whole population (n = 28, 100%) Preterm patients without cardiac disease (n = 10) Patients with cardiac disease (n = 18) p value
Sex [n (%)]
 Male
 Female
17 (71%)
11 (39%)
6 (60%)
4 (40%)
11 (61%)
7 (39%)
1.000
Gestational age [weeks [median (range)]] 32.7 (23.6–39.6) 31.1 (25.3–35.6) 36.5 (23.6–39.6) 0.142
Weight at birth [g [median (range)]] 1940 (550–3300) 1670 (780–2160) 2205 (550–3300) 0.245
Leading cardiac malformations [n (%)]
 Persisting ductus arteriosus
 Atrial/ventricular septal defect
 Pulmonary stenosis with double outlet ventricle
 Transposition of the great arteries
 Hypoplastic left heart syndrome
 Tetralogy of Fallot
 Ebstein’s anomaly
18 (64%)
5 (18%)
2 (7%)
2 (7%)
3 (11%)
3 (11%)
2 (7%)
1 (3%)
0 18 (100%)
5 (28%)
2 (11%)
2 (11%)
3 (17%)
3 (17%)
2 (11%)
1 (6%)
< 0.0001
0.128
0.524
0.524
0.533
0.533
0.524
1.000
BELL-stage [n (%)]
 IIb
 IIIa
 IIIb
10 (36%)
2 (7%)
16 (57%)
4 (40%)
1 (10%)
5 (50%)
6 (33%)
1 (6%)
11 (61%)
0.854
Perforation [n (%)]
 Yes
 No
16 (57%)
12 (43%)
5 (50%)
5 (50%)
11 (61%)
7 (39%)
0.698
Localization of NEC [n (%)]
 Small bowels
 Colon
 Both localizations
10 (36%)
11 (39%)
7 (25%)
5 (50%)
3 (30%)
2 (20%)
5 (28%)
8 (44%)
5 (28%)
0.602
Proof of bacteria (intraperitoneal swabs) [n (%)]
 Yes
 No
12 (43%)
16 (57%)
1 (10%)
9 (90%)
11 (61%)
7 (39%)
0.016
Proof of bacteria (intraperitoneal swabs) [n (%), multiple answers possible/patient]
E. coli
Enterobacter cloacae
Enterococcus
Staphylococcus
Serratia marcescens
Citrobacter koseri
3 (11%)
1 (4%)
4 (14%)
7 (25%)
1 (4%)
1 (4%)
1 (10%)
1 (10%)
3 (17%)
1 (6%)
3 (17%)
6 (33%)
1 (6%)
1 (6%)
0.533
1.000
1.000
0.364
1.000
1.000
Fulminant NEC [n (%)]
 Yes
 No
8 (29%)
20 (71%)
2 (20%)
8 (80%)
6 (33%)
12 (67%)
0.669
Short bowel syndrome [n (%)]
 Yes
 No
5 (18%)
23 (82%)
2 (20%)
8 (80%)
3 (17%)
15 (83%)
1.000
Survival [n (%)]
 Yes
 No
20 (71%)
8 (29%)
9 (90%)
1 (10%)
11 (61%)
7 (39%)
0.194
pH at diagnosis [median (range)] 7.32
(7.04–7.53)
7.31
(7.10–7.53)
7.33
(7.04–7.50)
0.488
Base excess at diagnosis [mmol/l [median (range)]] − 4.3 (− 17.0 to 6.3) − 6.9 (− 17.0 to − 2.1) − 2.1 (− 9.3 to 6.3) 0.013
Lactate at diagnosis [mmol/l [median (range)]] 2.5 (1.0–11.4) 2.3 (1.4–8.8) 3.0 (1.0–11.4) 0.924
White blood cell count at diagnosis [n × 109/l [median (range)]] 4.5 (0.5–23.1) 4.5 (0.5–9.3) 4.5 (1.3–23.1) 0.796
Platelet count at diagnosis [n/μl [median (range)]] 193.0 (22.0–571.0) 214.0 (22.0–314.0) 188.0 (51.0–571.0) 0.832
CrP at diagnosis [mg/l [median (range)]] 40.9 (0.6–259.0) 10.2 (0.6–259.0) 52.7 (10.8–220.3) 0.160
  1. Includes basic demographic and clinical data of the 28 included patients