Fig. 1

Primary granule mobilization and functional fates of human neutrophils. Recent studies have revealed the existence of multiple functional fates of neutrophils, which lead to different interactions with incoming bacteria (in red). Fusion of primary granules (in blue) to the phagosome drives neutrophils toward the classical phagocytic fate (1), while their mobilization to the nucleus drives them toward the extrusion of DNA-based extracellular traps in a process called “NETosis” (2). By contrast, primary granule fusion with the plasma membrane instead leads to hyperexocytosis and potential reprogramming (3), a third fate that further emphasizes the functional plasticity of human neutrophils