Fig. 7
From: Installation of the developing nephron in the fetal human kidney during advanced pregnancy
View onto the installation of the extended renal vesicle (extdRV) in the fetal human kidney during advanced pregnancy by the optical microscope. During this developmental phase, the vertical elongation of the CD ampulla (A) coincides with the internal folding. This causes that interstitial cleft lines from the connecting tubule (CNT) along the progenitor cell strand (white arrow heads) to the pretubular aggregate (PTA). While it elongates, it forms a deep oblique pocket. This step of installation enables the defoliation of the glomerulus (white triangles) at the lateral aspect of its proximal pole (PP). In contrast, the medial aspect of the extended renal vesicle shows a close course along the conus (CO) of the CD ampulla, which is later replaced by a narrow interstitial cleft (white circles). It expands in vertical direction. C renal capsule, PRA perforating radiate artery, black asterisk clear interface between the mesenchymal and epithelial progenitor cells in the nephrogenic niche, white asterisks adhesion, N neck of CD ampulla, CD collecting duct tubule, DP distal pole, C renal capsule