Fig. 3
From: Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE)
Neuromyelitis optica and retinitis in an 8-year-old jSLE patient. A Coronal MRI images showing perineural contrast enhancement of the right optic nerve in T1-weighted sequences (arrow). B Increased T2-weighted signal of the Nervus opticus and reduced signal of the nerve sheath (arrow) representing focal oedema of nerve and optic perineuritis. C Cotton-wool infiltrates resembling retinitis of the right eye in the same patient. The patient failed to respond to treatment with CPM and high-dose corticosteroids and was therefore treated with B cell depletion (rituximab), followed by repeated/cyclic immune-apheresis