From: Long noncoding RNAs as regulators of pediatric acute myeloid leukemia
Name | Role in pediatric AML | Cellular function | Clinical significance in pediatric AML | References |
---|---|---|---|---|
HOTTIP | Oncogenic in NPM1-mutated and KMT2A-r AML | Activation of posterior HOXA genes and other hematopoietic genes | High expression correlates with poor survival | [59] |
CDK6-AS1 | Oncogenic | Silencing of RUNX1 transcription and activation of mitochondrial biogenesis | High expression correlates with poor treatment response | [60] |
UCA1 | Oncogenic | Binding of various miRNAs | Unknown | |
MONC | Oncogenic in AMKL | Unknown | Unknown | [66] |
MIR100HG | Oncogenic in AMKL | Unknown | Unknown | [66] |
MEG3 | Tumor suppressive | Activation of p53 expression and DNMT3A | High expression correlates with better survival | |
HOXA10-AS | Oncogenic in KMT2A-r AML | Activation of the NF-κB pathway | High expression correlates with poor survival | [70] |
LINC00998 | Tumor suppressive | ZFP36 binding and reduction of mTORC2 mRNA stability | Low expression correlates with poor survival | [71] |
LINC01257 | Oncogenic in t(8;21) AML | Unknown | High expression correlates with poor survival | [72] |
MVIH | Oncogenic | Unknown | High expression correlates with poor treatment response and survival | [73] |
GAS6-AS1 | Oncogenic | Decoy for tumor-suppressive miRNA miR-370-3p | Unknown | [74] |
FBXL19-AS1 | Oncogenic | Unknown | High expression correlates with poor survival | [75] |
SNHG14 | Oncogenic | Decoy for tumor-suppressive miRNA miR-193-3p | Unknown | [76] |
DARS-AS1 | Oncogenic | Decoy for tumor-suppressive miRNA miR-425 | High expression correlates with poor survival | [77] |
TUG1 | Oncogenic | Decoy for tumor suppressive miRNA miR-221-3p | Unknown | [78] |
LINC00909 | Oncogenic | Decoy for tumor-suppressive miRNA miR-625 | High expression correlates with poor survival | [79] |
LAMP5-AS1 | Oncogenic in KMT2A-r AML | Activation of DOT1L and global H3K79 methylation | High expression correlates with poor survival | [80] |
LINC0064 | Oncogenic | Decoy for tumor-suppressive miRNA miR-378a | Unknown | [81] |
Lnc-SOX6-1 | Oncogenic | Unknown | High expression correlates with poor survival | [82] |
CCAT1 | Oncogenic in t(8;21) AML | Unknown | High expression correlates with poor survival | [83] |
PVT1 | Oncogenic in t(8;21) AML | Unknown | High expression correlates with poor survival | [83] |
CASC15 | Oncogenic in t(8;21) AML | Regulation of YY1-mediated transcription of SOX4 | No correlation to prognosis | [84] |
DLEU2 | Tumor suppressive in AML M5 | Unknown | No correlation to prognosis | [85] |