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Table 1 LncRNAs implicated in pediatric acute myeloid leukemia

From: Long noncoding RNAs as regulators of pediatric acute myeloid leukemia

Name Role in pediatric AML Cellular function Clinical significance in pediatric AML References
HOTTIP Oncogenic in NPM1-mutated and KMT2A-r AML Activation of posterior HOXA genes and other hematopoietic genes High expression correlates with poor survival [59]
CDK6-AS1 Oncogenic Silencing of RUNX1 transcription and activation of mitochondrial biogenesis High expression correlates with poor treatment response [60]
UCA1 Oncogenic Binding of various miRNAs Unknown [61,62,63,64,65]
MONC Oncogenic in AMKL Unknown Unknown [66]
MIR100HG Oncogenic in AMKL Unknown Unknown [66]
MEG3 Tumor suppressive Activation of p53 expression and DNMT3A High expression correlates with better survival [67,68,69]
HOXA10-AS Oncogenic in KMT2A-r AML Activation of the NF-κB pathway High expression correlates with poor survival [70]
LINC00998 Tumor suppressive ZFP36 binding and reduction of mTORC2 mRNA stability Low expression correlates with poor survival [71]
LINC01257 Oncogenic in t(8;21) AML Unknown High expression correlates with poor survival [72]
MVIH Oncogenic Unknown High expression correlates with poor treatment response and survival [73]
GAS6-AS1 Oncogenic Decoy for tumor-suppressive miRNA miR-370-3p Unknown [74]
FBXL19-AS1 Oncogenic Unknown High expression correlates with poor survival [75]
SNHG14 Oncogenic Decoy for tumor-suppressive miRNA miR-193-3p Unknown [76]
DARS-AS1 Oncogenic Decoy for tumor-suppressive miRNA miR-425 High expression correlates with poor survival [77]
TUG1 Oncogenic Decoy for tumor suppressive miRNA miR-221-3p Unknown [78]
LINC00909 Oncogenic Decoy for tumor-suppressive miRNA miR-625 High expression correlates with poor survival [79]
LAMP5-AS1 Oncogenic in KMT2A-r AML Activation of DOT1L and global H3K79 methylation High expression correlates with poor survival [80]
LINC0064 Oncogenic Decoy for tumor-suppressive miRNA miR-378a Unknown [81]
Lnc-SOX6-1 Oncogenic Unknown High expression correlates with poor survival [82]
CCAT1 Oncogenic in t(8;21) AML Unknown High expression correlates with poor survival [83]
PVT1 Oncogenic in t(8;21) AML Unknown High expression correlates with poor survival [83]
CASC15 Oncogenic in t(8;21) AML Regulation of YY1-mediated transcription of SOX4 No correlation to prognosis [84]
DLEU2 Tumor suppressive in AML M5 Unknown No correlation to prognosis [85]