Long noncoding RNAs as regulators of pediatric acute myeloid leukemia

Neyazi, Sina; Ng, Michelle; Heckl, Dirk; Klusmann, Jan-Henning

doi:10.1186/s40348-022-00142-2

Molecular and Cellular Pediatrics

Table 1 LncRNAs implicated in pediatric acute myeloid leukemia

From: Long noncoding RNAs as regulators of pediatric acute myeloid leukemia

Name	Role in pediatric AML	Cellular function	Clinical significance in pediatric AML	References
HOTTIP	Oncogenic in NPM1-mutated and KMT2A-r AML	Activation of posterior HOXA genes and other hematopoietic genes	High expression correlates with poor survival	[59]
CDK6-AS1	Oncogenic	Silencing of RUNX1 transcription and activation of mitochondrial biogenesis	High expression correlates with poor treatment response	[60]
UCA1	Oncogenic	Binding of various miRNAs	Unknown	[61,62,63,64,65]
MONC	Oncogenic in AMKL	Unknown	Unknown	[66]
MIR100HG	Oncogenic in AMKL	Unknown	Unknown	[66]
MEG3	Tumor suppressive	Activation of p53 expression and DNMT3A	High expression correlates with better survival	[67,68,69]
HOXA10-AS	Oncogenic in KMT2A-r AML	Activation of the NF-κB pathway	High expression correlates with poor survival	[70]
LINC00998	Tumor suppressive	ZFP36 binding and reduction of mTORC2 mRNA stability	Low expression correlates with poor survival	[71]
LINC01257	Oncogenic in t(8;21) AML	Unknown	High expression correlates with poor survival	[72]
MVIH	Oncogenic	Unknown	High expression correlates with poor treatment response and survival	[73]
GAS6-AS1	Oncogenic	Decoy for tumor-suppressive miRNA miR-370-3p	Unknown	[74]
FBXL19-AS1	Oncogenic	Unknown	High expression correlates with poor survival	[75]
SNHG14	Oncogenic	Decoy for tumor-suppressive miRNA miR-193-3p	Unknown	[76]
DARS-AS1	Oncogenic	Decoy for tumor-suppressive miRNA miR-425	High expression correlates with poor survival	[77]
TUG1	Oncogenic	Decoy for tumor suppressive miRNA miR-221-3p	Unknown	[78]
LINC00909	Oncogenic	Decoy for tumor-suppressive miRNA miR-625	High expression correlates with poor survival	[79]
LAMP5-AS1	Oncogenic in KMT2A-r AML	Activation of DOT1L and global H3K79 methylation	High expression correlates with poor survival	[80]
LINC0064	Oncogenic	Decoy for tumor-suppressive miRNA miR-378a	Unknown	[81]
Lnc-SOX6-1	Oncogenic	Unknown	High expression correlates with poor survival	[82]
CCAT1	Oncogenic in t(8;21) AML	Unknown	High expression correlates with poor survival	[83]
PVT1	Oncogenic in t(8;21) AML	Unknown	High expression correlates with poor survival	[83]
CASC15	Oncogenic in t(8;21) AML	Regulation of YY1-mediated transcription of SOX4	No correlation to prognosis	[84]
DLEU2	Tumor suppressive in AML M5	Unknown	No correlation to prognosis	[85]

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