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Molecular and Cellular Pediatrics
Fig. 3 | Molecular and Cellular Pediatrics

Fig. 3

From: Perinatal origins of chronic lung disease: mechanisms–prevention–therapy—sphingolipid metabolism and the genetic and perinatal origins of childhood asthma

Fig. 3

Schematic model for the genetic and extrinsic exposures affecting sphingolipid-driven asthma pathogenesis in children. 17q21 asthma risk alleles induce suboptimal de novo sphingolipid synthesis, which is exacerbated by perinatal and early life exposures including maternal obesity, mode of delivery, and intrapartum care, alterations to the host microbiome and respiratory viral infections. Together, these factors appear to tip the homeostatic balance away from the protective effects of a normal sphingolipid synthesis and toward the pathogenic effects of decreased de novo synthesis and increased S1P. Pregnant woman illustration author Sudowoodo, title "Bathroom and medical people icons stock illustration, USA, icon, people, women, men." Child with inhaler illustration author Irina_Strelnikova title "Asthma stock illustration: Asthmatic, Child, Inhaling, Illness, Asthma Inhaler", both provided by istockphoto.com

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