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Molecular and Cellular Pediatrics
Fig. 3 | Molecular and Cellular Pediatrics

Fig. 3

From: A fresh look to the phenotype in mono-allelic likely pathogenic variants of the leptin and the leptin receptor gene

Fig. 3

Illustration of individual body fat (BF) values [%] for children and adults in association with genotype for LEP (A, B) or LEPR (C, D) (wt/wt vs. wt/- vs. -/-; *p < 0.05). A Children: LEP wt/wt (n = 3): mean 17% (range 14–20%); LEP wt/- (n = 2): mean 19% (range 15–23%); LEP-/- (n = 6): mean 53% (range 50–57%). B Adults: LEP wt/wt (n = 0) LEP wt/- (n = 11): mean 28% (range 15–36%); LEP-/- (n = 2): mean 50.4% (range 42.8–57.9%); C Children: LEPR wt/wt (n = 7) mean 31% (range 18–49%); LEPR wt/- (n = 2): mean 20.5% (range 20–21%); LEPR-/- (n = 13): mean 54% (range 41–68%); D Adults: LEPR wt/wt (n = 7) mean 38% (range 20–52%); LEPR wt/- (n = 22) mean: 35% (range 18–48%); LEPR-/- (n = 7): mean 57% (range 50.7–66%)

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