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Molecular and Cellular Pediatrics
Fig. 1 | Molecular and Cellular Pediatrics

Fig. 1

From: Shaping of the nephron – a complex, vulnerable, and poorly explored backdrop for noxae impairing nephrogenesis in the fetal human kidney

Fig. 1

View of a nephrogenic compartment (framed) located in the nephrogenic zone (NZ) of the fetal human kidney by optical microscopy. The outer border is the renal capsule (C). The proximal pole (PP) of an S-shaped body (SSB) represents the inner border (dotted line). The medial border is the distal end of a collecting duct (CD) tubule dilating into a CD ampulla (A). It consists of a tip (T), head (H), conus (CO), and neck (N). The lateral border is a vertically lining perforating radiate artery (short black arrow). Epithelial progenitor cells in the tip of a CD ampulla, an interface (black asterisk), and nephrogenic mesenchymal progenitor cells (MES) indicate a nephrogenic niche. Induced mesenchymal progenitor cells become angular and develop the pretubular aggregate (PTA) along the tip of the CD ampulla

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