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Table 1 Endocrine investigations for monitoring children with isolated GHD

From: Evolving pituitary hormone deficits in primarily isolated GHD: a review and experts’ consensus

Pituitary hormone Baseline investigation Second-line investigation
TSH fT4, TSH Not needed
ACTH Morning cortisol (7–9 am) Synacthen test, insulin-hypoglycemia test
LH/FSH Inhibin B, LH, FSH, testosterone/estradiol GnRH agonist test
ADH Early morning serum/urine osmolality Water deprivation test, desmopressin test