Fig. 2

Proteasome inhibition induced HIF-1α level is controlled by autophagy inducing drug, cysteamine. a, b Western blots showing the changes in HIF-1α expression in total protein lysates isolated from Beas2b cells treated with MG-132 (5 μM) and/or cysteamine (250 μM) for 12 h. The data (mean ± SEM, n = 3) indicates that MG-132 treatment significantly elevates HIF-1α levels that were reduced by co-treatment with autophagy-inducing drug, cysteamine. (**p < 0.01; ***p < 0.001)