Leukocyte recruitment in preterm and term infants

Molecular and Cellular Pediatrics

Table 2 Expression of leukocyte adhesion molecules in neonates and adults

Molecule	Cell type	Expression in fetuses/premature neonates compared to adults and respective references
Mac-1	PMN	↓ Reduced ↑ Increased ↔ Equal	[26, 31, 36] [37] [30, 33]
LFA-1	PMN	↓ Reduced ↔ Equal	[26, 45] [30, 31, 36, 37]
CXCR2	PMN	↔ Equal	[31]
CD 18	PMN	↓ Reduced	[26]
L-selectin	PMN	↓ Reduced ↔ Equal	[26, 33, 37, 45, 46] [47]
E-selectin	Skin EC Yolk sac vessels	↓ Reduced ↓ Reduced ↓ Reduced	[38] [31] [29]
P-selectin	EC Fetal skin PMN Yolk sac vessels	↓ Reduced ↓ Reduced ↓ Reduced ↓ Reduced	[34] [38] [39] [29]
RAGE	PMN	↑ Increased	[30]
ICAM-1	Skin EC Yolk sac vessels	↓ Reduced ↓ Reduced ↓ Reduced	[38] [31] [29]
ICAM-2	Yolk sac vessels	↓ Reduced	[29]
VCAM-1	Skin Yolk sac vessels	↓ Reduced ↓ Reduced	[38] [29]
PSGL-1	PMN Yolk sac vessels	↓ Reduced ↓ Reduced	[31, 39] [29]
PECAM-1	EC Yolk sac vessels	↔ Equal ↔ Equal	[31] [29]
VE-cadherin	EC	↔ Equal	[31]
VLA-4	PMN	↓ Reduced	[45]

PECAM-1 platelet endothelial cell adhesion molecule 1, VE-cadherin vascular endothelial cadherin, VLA4 very late antigen 4, EC endothelial cells