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Table 1 Phenotypic categorization of SI mutants

From: The multiple roles of sucrase-isomaltase in the intestinal physiology

Phenotype of SI mutants Transport and function
I Blocked in the ER, enzymatically inactive
II Blocked in the ER, ER-Golgi intermediate compartment, and cis-Golgi, inactive
III Normal intracellular protein transport but absent activities
IV Sorting defects, enzymatically active
V Intracellular proteolytic cleavage and degradation of sucrase, normal transport and partial activity
VI Intracellular proteolytic cleavage and secretion of SI, complete activity
VII Altered trafficking and increased turnover rate, partially active