Skip to main content

Articles

Page 3 of 5

  1. Autism spectrum disorders (ASDs) are neurodevelopmental disorders with impaired social interactions and communication and restrictive, repetitive patterns of behaviors, interests, and activities. A recent epid...

    Authors: Michaela Kuhlen, Julia Taeubner, Dagmar Wieczorek and Arndt Borkhardt
    Citation: Molecular and Cellular Pediatrics 2017 4:8
  2. Chronic non-bacterial osteomyelitis (CNO) belongs to the growing spectrum of autoinflammatory diseases and primarily affects the skeletal system. Peak onset ranges between 7 and 12 years of age. The clinical s...

    Authors: Sigrun Ruth Hofmann, Franz Kapplusch, Katrin Mäbert and Christian Michael Hedrich
    Citation: Molecular and Cellular Pediatrics 2017 4:7
  3. Precursor B acute lymphoblastic leukemia (BCP-ALL), the most common childhood malignancy, arises from an expansion of malignant B cell precursors in the bone marrow. Epidemiological studies suggest that infect...

    Authors: Simone Bürgler and David Nadal
    Citation: Molecular and Cellular Pediatrics 2017 4:6
  4. Authors: Rhea van den Bruck, Patrick P. Weil, Thomas Ziegenhals, Philipp Schreiner, Stefan Juranek, Daniel Gödde, Silvia Vogel, Frauke Schuster, Valerie Orth, Johannes Dörner, Daniel Pembaur, Meike Röper, Stefan Störkel, Hubert Zirngibl, Stefan Wirth, Andreas C. W. Jenke…
    Citation: Molecular and Cellular Pediatrics 2017 4(Suppl 1):5

    This article is part of a Supplement: Volume 4 Supplement 1

  5. The intrauterine environment was long considered sterile. However, several infectious threats are already present during fetal life. This review focuses on the postnatal immunological consequences of prenatal ...

    Authors: Gijs T. J. van Well, Leonie A. Daalderop, Tim Wolfs and Boris W. Kramer
    Citation: Molecular and Cellular Pediatrics 2017 4:4
  6. Exposure to second-hand tobacco smoke (SHS) is one of the prime risk factors for chronic lung disease development. Smoking during pregnancy may lead to birth defects in the newborn that include pulmonary dysfu...

    Authors: Neel Patel, Christopher D. Trumph, Manish Bodas and Neeraj Vij
    Citation: Molecular and Cellular Pediatrics 2017 4:3
  7. The developmental origin of health and disease concept identifies the brain, cardiovascular, liver, and kidney systems as targets of fetal adverse programming with adult consequences. As the limits of viabilit...

    Authors: Amelie Stritzke, Sumesh Thomas, Harish Amin, Christoph Fusch and Abhay Lodha
    Citation: Molecular and Cellular Pediatrics 2017 4:2
  8. The pathological course of several chronic inflammatory diseases, including cystic fibrosis, chronic obstructive pulmonary disease, and rheumatoid arthritis, features an aberrant innate immune response dominat...

    Authors: Camilla Margaroli and Rabindra Tirouvanziam
    Citation: Molecular and Cellular Pediatrics 2016 3:38
  9. Rett syndrome is best known due to its severe and devastating symptoms in the central nervous system. It is produced by mutations affecting the Mecp2 gene that codes for a transcription factor. Nevertheless, evid...

    Authors: Pamela Millar-Büchner, Amber R. Philp, Noemí Gutierrez, Sandra Villanueva, Bredford Kerr and Carlos A. Flores
    Citation: Molecular and Cellular Pediatrics 2016 3:37
  10. Wilms’ tumor is an embryonal neoplasm of the kidney that accounts for approximately 6 % of all childhood tumors. The chemokine CXCL12 (C-X-C chemokine ligand 12) and its ligand CXCR4 (C-X-C chemokine receptor ...

    Authors: Patricia Midori Murobushi Ozawa, Carolina Batista Ariza, Roberta Losi-Guembarovski, Alda Losi Guembarovski, Carlos Eduardo Coral de Oliveira, Bruna Karina Banin-Hirata, Marina Okuyama Kishima, Diego Lima Petenuci and Maria Angelica Ehara Watanabe
    Citation: Molecular and Cellular Pediatrics 2016 3:36
  11. Impaired cellular innate immune defense accounts for susceptibility to sepsis and its high morbidity and mortality in preterm infants. Leukocyte recruitment is an integral part of the cellular immune response ...

    Authors: Katinka Karenberg, Hannes Hudalla and David Frommhold
    Citation: Molecular and Cellular Pediatrics 2016 3:35
  12. Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due...

    Authors: Chiharu Ota, Hoeke A. Baarsma, Darcy E. Wagner, Anne Hilgendorff and Melanie Königshoff
    Citation: Molecular and Cellular Pediatrics 2016 3:34
  13. Neonatal leukemia is a rare disease with an estimated prevalence of about one to five in a million neonates. The majority being acute myeloid leukemia (AML), neonatal leukemia can present with a variety of sym...

    Authors: Tobias Gyárfás, Juergen Wintgens, Wolfgang Biskup, Ilske Oschlies, Wolfram Klapper, Reiner Siebert, Susanne Bens, Claudia Haferlach, Roland Meisel, Michaela Kuhlen and Arndt Borkhardt
    Citation: Molecular and Cellular Pediatrics 2016 3:30
  14. Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limited recurrent attacks of fever and serositis. Patients may develop renal amyloidosis. Colchicine prevents attacks ...

    Authors: Betul Sozeri, Nesrin Gulez, Malik Ergin and Erkin Serdaroglu
    Citation: Molecular and Cellular Pediatrics 2016 3:33
  15. Asthma is the most common chronic disease starting in childhood and persisting into adulthood in many cases. During childhood, different forms of asthma and wheezing disorders exist that can be discriminated b...

    Authors: Michael Kabesch
    Citation: Molecular and Cellular Pediatrics 2016 3:31
  16. Influenza viruses (IVs) circulate seasonally and are a common cause of respiratory infections in pediatric and adult patients. Additionally, recurrent pandemics cause massive morbidity and mortality worldwide....

    Authors: Barbara Rösler and Susanne Herold
    Citation: Molecular and Cellular Pediatrics 2016 3:29
  17. Retinoic acid (RA), the active form of vitamin A, regulates key developmental processes in multiple organs. In the developing lung, RA is crucial for normal growth and differentiation of airways. Disruption in...

    Authors: Hector A. Marquez and Wellington V. Cardoso
    Citation: Molecular and Cellular Pediatrics 2016 3:28
  18. Asthma represents the most common chronic childhood disease worldwide. Whereas preschool children present with wheezing triggered by different factors (multitrigger and viral wheeze), clinical asthma manifesta...

    Authors: Katja Landgraf-Rauf, Bettina Anselm and Bianca Schaub
    Citation: Molecular and Cellular Pediatrics 2016 3:27
  19. Bronchopulmonary dysplasia is a chronic lung disease of preterm infants. It is caused by the disturbance of physiologic lung development mainly in the saccular stage with lifelong restrictions of pulmonary fun...

    Authors: Tayyab Shahzad, Sarah Radajewski, Cho-Ming Chao, Saverio Bellusci and Harald Ehrhardt
    Citation: Molecular and Cellular Pediatrics 2016 3:23
  20. Neonatal lactic acidosis can be associated to severe inborn errors of metabolism. Rapid identification of the underlying disorder may improve the clinical management through reliable counseling of the parents ...

    Authors: Walid Fazeli, Mert Karakaya, Peter Herkenrath, Anne Vierzig, Jörg Dötsch, Jürgen-Christoph von Kleist-Retzow and Sebahattin Cirak
    Citation: Molecular and Cellular Pediatrics 2016 3:22
  21. About 150 human rhinovirus serotypes are responsible for more than 50 % of recurrent upper respiratory infections. Despite having similar 3D structures, some bind members of the low-density lipoprotein recepto...

    Authors: Dieter Blaas and Renate Fuchs
    Citation: Molecular and Cellular Pediatrics 2016 3:21
  22. The gut mucosa is continuously exposed to food and microbial antigens. Both enterocytes and intraepithelial lymphocytes have a pivotal role in maintaining the integrity of intestinal mucosa, as these cells gua...

    Authors: Serena Vitale, Stefania Picascia and Carmen Gianfrani
    Citation: Molecular and Cellular Pediatrics 2016 3:20
  23. Alveologenesis is the last stage in lung development and is essential for building the gas-exchanging units called alveoli. Despite intensive lung research, the intricate crosstalk between mesenchymal and epit...

    Authors: Cho-Ming Chao, Alena Moiseenko, Klaus-Peter Zimmer and Saverio Bellusci
    Citation: Molecular and Cellular Pediatrics 2016 3:17
  24. Asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) are all chronic pulmonary diseases, albeit with different etiologies, that are characterized by airflow limitation, chronic inflam...

    Authors: Robert C. Fellner, Shawn T. Terryah and Robert Tarran
    Citation: Molecular and Cellular Pediatrics 2016 3:16
  25. After birth, adequate lung function is necessary for the successful adaptation of a preterm baby. Both prenatal and postnatal insults and therapeutic interventions have an immediate effect on lung function and...

    Authors: Matthias C. Hütten, Tim G. A. M. Wolfs and Boris W. Kramer
    Citation: Molecular and Cellular Pediatrics 2016 3:15
  26. The maintenance of oxygen homeostasis in human tissues is mediated by several cellular adaptations in response to low-oxygen stress, called hypoxia. A decrease in tissue oxygen levels is initially counteracted...

    Authors: Nathalie E. Zeitouni, Sucheera Chotikatum, Maren von Köckritz-Blickwede and Hassan Y. Naim
    Citation: Molecular and Cellular Pediatrics 2016 3:14
  27. Cystic fibrosis (CF) is a lethal monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that entails the (diagnostic) increase in sweat electrolyte concent...

    Authors: Speranza Esposito, Antonella Tosco, Valeria R. Villella, Valeria Raia, Guido Kroemer and Luigi Maiuri
    Citation: Molecular and Cellular Pediatrics 2016 3:13
  28. Bacterial and fungal infections are hallmarks of cystic fibrosis (CF) lung disease. In the era of long-term inhaled antibiotics and increasing CF patient survival, new “emerging” pathogens are detected in CF a...

    Authors: Andreas Hector, Nina Frey and Dominik Hartl
    Citation: Molecular and Cellular Pediatrics 2016 3:12
  29. Incomplete intestinal absorption of fructose might lead to abdominal complaints such as pain, flatulence and diarrhoea. Whether defect fructose transporters such as GLUT5 or GLUT2 are involved in the pathogene...

    Authors: Karolin Ebert and Heiko Witt
    Citation: Molecular and Cellular Pediatrics 2016 3:10
  30. Bacterial infection often leads to cellular damage, primarily marked by loss of cellular integrity and cell death. However, in recent years, it is being increasingly recognized that, in individual cells, there...

    Authors: Helena Pillich, Maria Loose, Klaus-Peter Zimmer and Trinad Chakraborty
    Citation: Molecular and Cellular Pediatrics 2016 3:9
  31. Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Some gliadin peptides are not digested by intestinal proteases and can have diff...

    Authors: M. Vittoria Barone and K. Peter Zimmer
    Citation: Molecular and Cellular Pediatrics 2016 3:8
  32. Irritable bowel syndrome (IBS) is a common condition with a complex and largely unknown etiology. There is no cure, and treatment options are mainly directed to the amelioration of symptoms. IBS causes reduced...

    Authors: Maria Henström and Mauro D’Amato
    Citation: Molecular and Cellular Pediatrics 2016 3:7
  33. Perinatal complications in both term- and preterm-born infants are a leading cause of neonatal morbidities and mortality. Infants face different challenges in the neonatal intensive care unit with long-term mo...

    Authors: Martin Mueller, Tim G. A. Wolfs, Andreina Schoeberlein, Antonio W. D. Gavilanes, Daniel Surbek and Boris W. Kramer
    Citation: Molecular and Cellular Pediatrics 2016 3:6
  34. Primary sucrase-isomaltase deficiency, originally thought to be a homozygous recessive disorder, has been found to have numerous genetic variants that alone or in combination (compound heterozygosity) express ...

    Authors: Stanley A. Cohen
    Citation: Molecular and Cellular Pediatrics 2016 3:5
  35. Starch requires six enzymes for digestion to free glucose: two amylases (salivary and pancreatic) and four mucosal maltase activities; sucrase-isomaltase and maltase-glucoamylase. All are deficient in suckling...

    Authors: B. L. Nichols, M. Diaz-Sotomayor, S. E. Avery, S. K. Chacko, D. L. Hadsell, S. S. Baker, B. R. Hamaker, L. K. Yan, H. M. Lin and R. Quezada-Calvillo
    Citation: Molecular and Cellular Pediatrics 2016 3:4
  36. Microvillus inclusion disease (MVID) is characterised by onset of intractable life-threatening watery diarrhoea during infancy. Transmission electron microscopy demonstrates shortening or absence of apical mic...

    Authors: Georg F. Vogel, Michael W. Hess, Kristian Pfaller, Lukas A. Huber, Andreas R. Janecke and Thomas Müller
    Citation: Molecular and Cellular Pediatrics 2016 3:3
  37. Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the intestine. IBD is a multifactorial disorder, and IBD-associated genes are critical in innate immune response, inflammatory re...

    Authors: Yatrik M. Shah
    Citation: Molecular and Cellular Pediatrics 2016 3:1
  38. Childhood arterial ischemic stroke (CAIS) is increasingly recognized as an important cause of significant long-term morbidity in the pediatric population. Post stroke movement disorders, above all hemi-dystoni...

    Authors: Daniel Tibussek, Ertan Mayatepek, Dirk Klee and Anne Koy
    Citation: Molecular and Cellular Pediatrics 2015 2:14