Fig. 1

Schematic overview of human and zebrafish urinary tract. A Schematics of human urinary system. Topological subdivisions of the phenotypic complexity of BEEC (red) and LUTO (blue) are depicted. B Overview of zebrafish urinary system. It is composed of 2 nephrons with a pair of glomeruli (bright red) and tubules that can be divided in a proximal and distal segment. The proximal part is subdivided into neck (orange), proximal convoluted (yellow) and proximal straight tubule (green). The distal portion is divided in distal early (blue), corpuscle of Stannius (brown) and distal late (purple). The last segment depicts the pronephric duct (pink) that distally fuses with the cloaca (dark red). C Schematic depiction of cloacal region at 120 hpf. The hindgut (green) opens to the exterior, adjacent to the pronephric duct (pink), both fusing with the cloaca (dark red). Created with BioRender.com