Table 1 Characteristics of SCFN in newborns

Age at diagnosis of SCFN [days after birth]

N

297

42

136

8

108

mean ± SD

11.3 ± 11.6

11.1 ± 9.1

11.8 ± 12.0

6.3 ± 5.8

11.4 ± 12.3

Size of skin lesion (cm²)

N

83

20

36

1

26

mean ± SD

17.3 ± 38.1

19.0 ± 33.8

24.3 ± 50.3

3.8 ± 0

8.1 ± 9.8

Symptoms at time of diagnosis

N

285

22

194

6

63

Radial paresis

N (%)

30 (10.5)

1 (4.5)

0 (0.0)

0 (0.0)

29 (46.0)

Vomiting, diarrhoea

N (%)

29 (10.2)

1 (4.5)

25 (12.9)

0 (0.0)

3 (4.8)

Failure to thrive

N (%)

28 (9.8)

1 (4.5)

27 (13.9)

0 (0.0)

0 (0.0)

Fever

N (%)

25 (8.8)

3 (13.6)

17 (8.7)

0 (0.0)

5 (7.9)

Heart disease

N (%)

21 (7.4)

6 (27.3)

13 (6.7)

2 (33.3)

0 (0.0)

Weight loss

N (%)

18 (6.3)

1 (4.5)

16 (8.2)

0 (0.0)

1 (1.6)

Poor feeding (breast milk/formula)

N (%)

18 (6.3)

2 (9)

15 (7.7)

0 (0.0)

1 (1.6)

Increased excitability

N (%)

17 (6.0)

0 (0.0)

16 (8.2)

0 (0.0)

1 (1.6)

Muscular hypotonia

N (%)

11 (3.9)

0 (0.0)

8 (4.1)

1 (16.7)

2 (3.2)

Lethargy

N (%)

11 (3.9)

0 (0.0)

8 (4.1)

0 (0.0)

3 (4.8)

Dehydration

N (%)

10 (3.5)

0 (0.0)

8 (4.1)

0 (0.0)

3 (4.8)

Further^a

N (%)

37 (23.5)

6 (27.3)

41 (21.1)

3 (50.0)

17 (27.0)

Serum calcium concentration [mmol/l]

N

–

–

111

–

–

Mean ± SD

–

–

3.6 ± 0.6

–

–

Ionised calcium [mmol/l]

N

–

–

19

–

–

Mean ± SD

–

–

1.8 ± 1.0

–

–

Vitamin D concentration (25(oH)D3) [ng/ml]

N

33

–

–

–

–

Mean ± SD

23.9 ± 15.8

–

–

–

–

1,25(OH)2D3 [pmol/l]

N

39

–

–

–

–

Mean ± SD

212.9 ± 135.3

–

–

–

–

Parathormon concentration [pmol/l]

N

28

–

–

–

–

Mean ± SD

14.1 ± 38.5

–

–

–

–

Serum triglycerid concentration [mg/dl]

N

18

2

14

2

–

Mean ± SD

346.3 ± 177.9

214 ± 75

383.3 ± 183.5

219.2 ± 12.7

–

Time between diagnosis of SCFN and electrolyte disturbance

N

122

–

114

8

–

Mean ± SD

18.6 ± 32.2

–

19.3 ± 32.7

8.8 ± 24.0

–

Calcifications in relation to localisation

N

97

5

85

1

6

Kidney

N (%)

46 (47.4)

0 (0.0)

45 (53.0)

0 (0.0)

1 (16.7)

subcutanous

N (%)

36 (37.1)

5 (100)

26 (30.6)

1 (100)

4 (66.7)

Brain

N (%)

4 (4.1)

0 (0.0)

4 (4.7)

0 (0.0)

0 (0.0)

Myocard

N (%)

3 (3.1)

0 (0.0)

2 (2.4)

0 (0.0)

1 (16.7)

Liver

N (%)

3 (3.1)

0 (0.0)

3 (3.5)

0 (0.0)

0 (0.0)

Blood vessels

N (%)

2 (2.1)

0 (0.0)

2 (2.4)

0 (0.0)

0 (0.0)

Stomach

N (%)

1 (1.0)

0 (0.0)

1 (1.2)

0 (0.0)

0 (0.0)

Bronchia

N (%)

1 (1.0)

0 (0.0)

1 (1.2)

0 (0.0)

0 (0.0)

Metaphyses

N (%)

1 (1.0)

0 (0.0)

1 (1.2)

0 (0.0)

0 (0.0)

Symptoms and course of SCFN

N

140

26

65

8

41

duration until healing [days]

Mean ± SD

90.8 ± 65.1

90.8 ± 60.2

100.6 ± 78.3

79.5 ± 43.9

77.3 ± 41.8