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Fig. 1 | Molecular and Cellular Pediatrics

Fig. 1

From: The interstitium at the developing nephron in the fetal kidney during advanced pregnancy — a microanatomical inventory

Fig. 1

ae View onto the renal capsule (C light blue/zigzag) and the external part of the nephrogenic zone (NZ) in the a fetal human kidney during advanced pregnancy and be the neonatal rabbit kidney. a By the optical microscope, one can recognize in the external capsula fibrosa (CF) arterial, venous, and lymphatic vessels between the bundles of collagen. In the subjacent tunica muscularis (TM), smooth muscle cells are seen. Between the inner side of the renal capsule and the tip of a CD ampulla (A dark blue/vertical double arrow), a transverse outer layer of interstitial/stromal (SP) and 2 to 3 inner layers of nephrogenic (NP) progenitor cells are present. The innermost layer is separated by a clear interface (black asterisks) from the subjacent tip of a collecting duct (CD) ampulla (A). b Immunohistochemical label for collagen type 3 depicts that the tip of a CD ampulla is linked via microfibers (arrow head) with the inner side of the renal capsule. c Contrasting by tannic acid for transmission electron microscopy illustrates a pronounced label at the interface, which surrounds the tip of a CD ampulla. Higher magnification of d tannic acid or e cupromeronic blue contrasted specimens indicates that textured extracellular matrix is contained at the lamina rara (Lr), densa (Ld), and fibroreticularis (Lf) of the here occurring basal lamina. PTA, pretubular aggregate (black arrow, PRA), perforating radiate artery

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