Fig. 1

HOXA10-AS, an example of a lncRNA regulator of hematopoiesis and pediatric leukemia. A HOXA10-AS, is overexpressed in pediatric AML with KMT2A rearrangements, where it increases leukemic proliferation via activation of the NF-κB signaling pathway. B Knockdown of HOXA10-AS using shRNAs leads to reduced growth of KMT2A-r AML patient blasts in vivo. C HOX10-AS is specifically expressed in hematopoietic stem cells and downregulated during hematopoietic differentiation. D Upon overexpression in hematopoietic stem and progenitor cells (HSPCs), HOXA10-AS impairs monocytic differentiation through the activation of NF-κB target genes