Fig. 2
From: How FGF23 shapes multiple organs in chronic kidney disease
Secondary diseases caused by high FGF23 in CKD. Patients with chronic kidney disease (CKD) show enhanced synthesis of fibroblast growth factor (FGF) 23 in the bone leading to increased FGF23 in the circulation. High FGF23 in CKD promotes CKD progression, left ventricular hypertrophy, vascular alterations, and cognitive impairment. Whether or not FGF23 contributes to mineralization defects in CKD is still unclear. Created with BioRender.com