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Fig. 2 | Molecular and Cellular Pediatrics

Fig. 2

From: The mutual patterning between the developing nephron and its covering tissues—valid reasons to rethink the search for traces left by impaired nephrogenesis

Fig. 2

Graphical sketches depicting the translocation of the developing nephron in a nephrogenic compartment of the fetal human kidney during late gestation. In the district of progenitor cell recruitment (light) the a nephrogenic niche (black asterisk) with the pretubular aggregate (PTA), b the mesenchymal to epithelial transition, and c the primitive renal vesicle (RV) are visible. In the underlying area of nephron shaping (dark), the d mature, e extending, f extended renal vesicles, the g early, h mid, and i late comma-shaped body (CSB) and the j early, k mid, and l late S-shaped body (SSB) are registered. While the district of progenitor cell recruitment maintains a constant size, the area of nephron shaping continues to expand during the formation of c the matured renal vesicle (15 × 20 µm) to l the late S-shaped body (100 × 100 µm). Renal capsule (C), collecting duct (CD) tubule, CD ampulla (A), perforating radiate artery (PRA, short black arrow), and lumen of the arising nephron + 

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