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Molecular and Cellular Pediatrics
Fig. 1 | Molecular and Cellular Pediatrics

Fig. 1

From: The mutual patterning between the developing nephron and its covering tissues—valid reasons to rethink the search for traces left by impaired nephrogenesis

Fig. 1

View of the stages of nephron anlage, restricted to the nephrogenic zone in the fetal human kidney during late gestation through the optical microscope. The development of a single nephron takes place in a nephrogenic compartment. Within its district of progenitor cell recruitment, a the nephrogenic niche (black asterisk) and the pretubular aggregate (PTA), b the mesenchymal to epithelial transition, and c the appearance of the primitive renal vesicle (RV) is registered. In its underlying area of nephron shaping the d mature, e extending, and f extended renal vesicles are seen. Then, the g early, h mid, and i late comma-shaped bodies (CSB) and the j early, k mid and l late S-shaped bodies (SSB) develop. Renal capsule (C), collecting duct (CD) tubule, CD ampulla (A) composed of a tip (T), head (H), conus (CO) and neck (N), perforating radiate artery (PRA, short black arrow), lumen of the arising nephron + . Transverse double line: border between the district of progenitor cell recruitment and the area of nephron shaping. Dotted line: border between the external nephrogenic zone and the subjacent maturation zone. Individual images have been previously published [10]

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