Fig. 5

A, B Illustration of individual BMI z scores in children (A) and adults (B) depending on LEPR genotype (wt/wt vs. wt/- vs. wt/-; *p ≤ 0.05). A Children: LEPR wt/wt (n = 13): mean 0.5 (range 0.4–0.6); LEPR wt/- (n = 7): mean 0.9 (range − 1.6–2.4); LEPR-/- (n = 17): mean 5.7 (range 3.3–10.6); B Adults: LEPR wt/wt (n = 10): mean 2.5 (range 0.4–5.0); LEPR wt/- (n = 60): mean 1.2 (range − 1.0–3.8); LEPR-/- (n = 30): mean 4.5 (range 0.4–6.1); C BMI z scores in association with LEPR variant (green circle: wt/wt subject; blue square: wt/- subject; red triangle: -/- subject; unfilled red triangle: compound wt/- subject) (Only variants reported to be carried by wt/- are shown). However, not always a BMI z score for the wt/- carrier could be calculated. It is not distinguished between children and adults. Subjects reported in different studies, but showing the same variant are grouped together. If wt/wt subjects in one family with two different wt/- variants were described, they BMI z scores were plotted for both variants)