Fig. 2From: Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortalityThe pathophysiological mechanism of the Ruvbl1 epidermal phenotype may involve reduced proliferation and accumulation of p53. Immunohistochemical staining was performed on epidermal tissue of Ruvbl1 knockout embryos and control littermates on day E14.5. Ki67 staining (upper panel), a marker for proliferation, was decreased in Ruvbl1 epidermal knockout mice. In addition, an increased expression of p53 in the epidermal cells of Ruvbl1 epidermal knockout mice was observed. There were no obvious differences in the staining of cleaved caspase 3, yH2AX, ß-catenin, or c-mycBack to article page