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Fig. 1 | Molecular and Cellular Pediatrics

Fig. 1

From: Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality

Fig. 1

Epidermal knockout of Ruvbl1 leads to severe skin development defects. a Although no living animals were observed, Ruvbl1 epidermal knockout embryos (Ruvbl1fl/flK14:Cretg) are found in normal Mendelian ratios. The quantification summarizes mice from all embryonic stages examined. b Specific numbers of genotyped animals from different embryonic stages examined do not show a clear-cut pattern (E12.5, E14.5, E16.5, E18.5). c Immunostainings for Ruvbl1 on day E14.5 confirms loss of Ruvbl1 protein in Ruvbl1 knockout mice. Control mice were Ruvbl1fl/flK14:Creneg. d Macroscopic images of Ruvbl1fl/flK14:Cretg mice and control littermates demonstrate very thin skin and lacking skin folds in Ruvbl1fl/flK14:Cretg mice during the course of development. e A skin barrier assay shows a strong defect in the skin barrier in Ruvbl1fl/flK14:Cretg mice. f Histological HE staining show defects in general skin development in Ruvbl1fl/flK14:Cretg mice starting in early embryonic development. g Immunostaining against K14 shows almost complete loss of epidermal tissue during late embryonic phases in Ruvbl1fl/flK14:Cretg mice

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