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Table 1 Selected clinical OAI studies

From: Shedding light on pediatric diseases: multispectral optoacoustic tomography at the doorway to clinical applications

Anatomical region/organChromophoresWavelength (nm)Clinical outputReferences
Non-melanoma skin cancerHbR, HbO2, melanin700, 715, 730, 760, 780, 790, 800, 825, 850, 900Mapping and visualization of skin cancer[13, 14]
Skin (hair follicles)HbR, HbO2, melanin, lipids660–1300Measurement of the structural and physiological features of intact hair follicles[15]
VasculatureHbR, HbO2700–850Noninvasive diagnosis and monitoring of vascular malformations[16]
HbR, HbO2700–960Clinical flow-mediated dilatation measurements[17]
HbO2. HbR, SO2730, 750, 800, 830Visualization of blood vessels, microvasculature and the respective oxygen saturation[18]
HbO2, HbR, melanin730, 760, 790, 820, 850Real-time visualization of blood vessels in 3D[19, 20]
HbO2, HbR, SO2760, 850Movement correction and artifact-free imaging[21]
HbO2, HbR, melanin700, 720, 740, 760, 780, 800, 820, 840, 860Human angiography[22, 23]
HbO2, HbR680–950, 1064Visualization of human carotid artery[24]
Sentinel lymph node (SLN)Melanin, ICG700, 730, 760, 800, 850, 900Identification of SLNs[25]
Melanin, ICG700, 730, 760, 800, 850Metastatic status of lymph nodes[26]
Hb, methylene blue650, 1064Identification of SLNs[27]
Inflammatory bowel diseaseHbT, HbO2, HbR, SO2700, 730, 760, 800, 850, 900Inflammatory disease activity in Crohn’s disease[28, 29]
Breast (cancer)HbT, HbO2, HbR, SO2700, 730, 760, 800, 850Characterization of healthy tissue and malignant lesions[30]
HbO2, HbR, water, lipid700–970 (10 nm steps) [31]
HbO2, HbR730, 760, 850 [32]
ThyroidHbT, HbO2, HbR, SO2, water, lipids700, 730, 760, 800, 850, 900, 920, 950Non-invasive diagnostics by tissue characterization[33]
Optical features of thyroid anatomy[34]
HbO2, HbR, water, lipid760, 850, 930, 970Differentiation between malignant and benign thyroidal nodules[35]
HbO21064Photoacoustic/ultrasound dual imaging of human thyroid cancer[36]
Systemic sclerosisHbT, HbO2, HbR700, 730, 750, 800, 850Disease activity[37]
MuscleHbT, HbO2, HbR, lipids, collagens680, 700, 730, 760, 800, 850, 920, 1000, 1030, 1064, 1100Disease extent in DMD patients[38]
  1. HbR deoxygenated hemoglobin, HbO2 oxygenated hemoglobin, HbT total hemoglobin, SO2 MSOT-derived oxygen saturation