Skip to main content

Table 1 Summary of all observed marker on granulocyte and monocytes and their subpopulations

From: Functional analysis of granulocyte and monocyte subpopulations in neonates

 MarkerChange (compared with adult)Adult (median (Min–Max))Neonate (median (Min–Max))p value (Mann-Whitney test)
GranulocytesCD11b+ (%)98.94 (97.83–99.78)95.27 (29.87–97.73)0.0001
CD11b+ (MFI)-3423 (2274–6123)2936 (1847–5151)0.5974
CD16+ (%)98.05 (93.91–99.32)89.59 (28.21–96.12)0.0002
CD16+ (MFI)58.687 (40.735–76.909)26.939 (26.309–36.276)0.0001
CD32+ (%)99.53 (98.11–99.85)97.14 (32.18–99.41)0.0017
CD32+ (MFI)-16.466 (12.504–27.052)19.779 (11.886–24.551)0.3418
CD62L+ (%)96.55 (93.15–99.34)85.07 (32.05–92.36)0.0001
CD62L+ (MFI)43.841 (21.105–64.313)19.172 (12.638–31.370)0.0028
TLR2+ (%)2.9 (0.6–10.98)8.36 (3.32–72.73)0.0035
TLR2+ (MFI)-1506 (190.9–5427)778.7 (365.3–3335)0.8053
Granulocytes subsetsCD16+ CD62L+93.01 (87.46–96.55)74.37 (25.78–81.35)0.0001
CD16+ CD62L−-3.24 (0.54–8.1)6.68 (0.21–16.0)0.2453
CD16dim CD62L+0.425 (0.25–1.18)1.06 (0.37–3.8)0.0092
CD16+CD62L+ (classical)CD11b+ (%)-100.0 (98.67–100)99.40 (97.76–100)0.0545
CD11b+ (MFI)-3439 (2284–6139)2978 (1880–5259)0.5974
CD32+ (%)-100.0 (100.0–100.0)100.0 (99.97–100.0)-
CD32+ (MFI)-16.655 (12.794–27.373)20.943 (13.267–27.917)0.098
TLR2+ (%)0.985 (0.32–11.52)5.75 (0.46–79.95)0.0346
TLR2+ (MFI)-1598 (360.3–5217)1013 (613.4–3321)0.8603
CD16+CD62L- (anti-inflammatory)CD11b+ (%)-98.43 (94.62–99.85)98.17 (92.92–99.48)0.3787
CD11b+ (MFI)-3332 (2040–5834)2753 (1686–3902)0.3418
CD32+ (%)-99.99 (99.61–100.0)99.96 (54.96–100.0)0.0587
CD32+ (MFI)-15.244 (11.030–26.700)19.774 (13.674–27.184)0.0726
TLR2+ (%)0.98 (0.27–6.67)5.97 (0.57–81.36)0.0183
TLR2+ (MFI)-2028 (443.6–7026)941.5 (634.4–3216)0.4181
CD16dimCD62L+ (pro-inflammatory)CD11b+ (%)-98.46 (81.77–100)97.05 (82.95–99.86)0.5495
CD11b+ (MFI)-2457 (1516–5741)2731 (2171–4653)0.3787
CD32+ (%)-100 (98.5–100.0)99.97 (99.36–100.0)0.9697
CD32+ (MFI)-8236 (5792–16.004)7168 (4230–10.209)0.5035
TLR2+ (%)1.4 (0.0–5.5)9.18 (0.73–35.08)0.0043
TLR2+ (MFI)2625 (0.00–5333)657.8 (446.7–3439)0.0378
MonocytesCD11b+ (%)99.51 (98.50–99.96)98.64 (95.76–99.33)0.0137
CD11b+ (MFI)-2694 (1256–6598)2093 (993.4–4453)0.1489
CD16+ (%)9.33 (5.91–11.38)21.26 (10.97–49.66)0.0003
CD16+ (MFI)12.126 (5745–19.915)3684 (1817–5825)0.0002
CD32+ (%)-99.93 (99.04–99.98)99.65 (92.43–99.82)0.0724
CD32+ (MFI)-22.733 (12.835–31.849)19.335 (13.609–30.177)0.5035
CD62L (%)94.24 (55.77–96.31)80.15 (27.67–96.15)0.0083
CD62L+ (MFI)28.574 (15.121–61.757)11.974 (5130–25.963)0.0011
HLA-DR+ (%)99.51 (97.14–99.83)94.46 (85.72–97.56)0.0002
HLA-DR+ (MFI)5050 (3839–5678)2008 (1135–4030)0.0002
TLR2+ (%)99.07 (95.67–99.83)97.27 (92.02–99.30)0.0317
TLR2+ (MFI)-3693 (2511–5553)3166 (1271–5754)0.1131
Monocyte subsetsCD14+ CD16+5.925 (4.47–9.33)17.52 (9.89–45.38)0.0001
CD14+CD16-90.59 (88.62–94.09)79.4 (50.34–88.55)0.0001
CD14dim CD16+-2.1 (1.12–5.77)1.74 (0.35–5.34)0.1299
CD14+CD16- (classical)CD11b+ (%)99.77 (98.59–99.98)98.26 (94.89–99.29)0.0006
CD11b+ (MFI)-2709 (1250–6706)2025 (914.2–4189)0.13
CD32+ (%)99.94 (99.27–99.99)99.67 (93.55–99.8)0.0183
CD32+ (MFI)-22.650 (12.310–31.390)18.040 (12.880–27.480)0.2453
CD62L+ (%)96.81 (57.66–98.74)82.53 (26.2–98.1)0.0054
CD62L+ (MFI)29.690 (15.240–64.070)12.150 (5195–28.160)0.0014
HLA-DR+ (%)99.57 (98.29–99.87)95.59 (88.84–99.24)0.0003
HLA-DR+ (MFI)4260 (3050–4736)1833 (907.4–2658)0.0001
TLR2+ (%)99.69 (97.23–99.96)97.89 (94.51–99.29)0.0151
TLR2+ (MFI)-3671 (2465–5485)2944 (1225–5206)0.0845
CD14+CD16+ (anti-inflammatory)CD11b+ (%)-99.85 (97.72–100.0)99.92 (98.06–100.0)0.5714
CD11b+ (MFI)-3009 (1441–6496)2643 (1357–5016)0.4181
CD32+ (%)-99.93 (96.42–100.0)99.77 (90.23–99.94)0.4165
CD32+ (MFI)-24.030 (14.400–40.560)22.930 (16.130–34.550)0.6985
CD62L+ (%)-74.74 (35.97–86.96)75.91 (42.13–95.42)0.5973
CD62L+ (MFI)16.240 (11.660–23.330)12.150 (4641–20.090)0.0221
HLA-DR+ (%)99.16 (87.21–100.0)93.53 (64.45–96.81)0.0378
HLA-DR+ (MFI)14.880 (10.390–19.610)3219 (2243–7424)0.0001
TLR2+ (%)-98.54 (82.51–99.77)95.53 (87.48–99.86)0.5495
TLR2+ (MFI)-4893 (3280–6613)3546 (1492–6474)0.0528
CD14dimCD16+ (pro-inflammatory)CD11b+ (%)-98.17 (89.87–99.83)96.82 (86.89–98.53)0.3418
CD11b+ (MFI)-1523 (803.7–3416)1250 (1027–2207)0.5974
CD32+ (%)-98.87 (85.65–100.0)96.11 (83.81–100.0)0.09
CD32+ (MFI)-15.860 (10.070–34.790)14.650 (11.360–22.380)0.2178
CD62L+ (%)-32.15 (13.08–44.67)34.89 (5.3–53.33)0.8053
CD62L+ (MFI)-9512 (4503–31.870)16.650 (7670–25.480)0.1131
HLA-DR+ (%)92.48 (75.53–98.71)63.51 (46.67–95.24)0.0151
HLA-DR+ (MFI)12.550 (7028–15.170)8144 (3757–11.960)0.0017
TLR2+ (%)-84.39 (61.21–97.33)76.67 (41.11–91.01)0.1697
TLR2+ (MFI)-3529 (2709–5068)3104 (1390–4592)0.13