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Table 1 Intracellular calgranulin functions

From: The role of S100 proteins in the pathogenesis and monitoring of autoinflammatory diseases

  S100A8/A9 S100A12
Neutrophils
- Ca2+ store/sensor [2]
- ↑Phagocytosis [20]
- ↑ROS [31], S100A8: ↓ROS [23]
- Ca2+-dependent interaction with cytoskeleton [27, 29, 32]: ↑migration, ↑degranulation, ↑phagocytosis
- S100A9 ↓microtubule polymerization [32]
- Zn2+-homeostasis? [26]
Monocytes
- Ca2+ store/sensor [2]
- Ca2+-dependent interaction with cytoskeleton [27, 29, 32]: ↑migration, ↑degranulation, ↑phagocytosis
- S100A9 ↓microtubule polymerization [32]