Table 1 Intracellular calgranulin functions
From: The role of S100 proteins in the pathogenesis and monitoring of autoinflammatory diseases
S100A8/A9 | S100A12 | |
|---|---|---|
Neutrophils
| - Ca2+ store/sensor [2] - ↑Phagocytosis [20] - ↑ROS [31], S100A8: ↓ROS [23] - Ca2+-dependent interaction with cytoskeleton [27, 29, 32]: ↑migration, ↑degranulation, ↑phagocytosis - S100A9 ↓microtubule polymerization [32] | - Zn2+-homeostasis? [26] |
Monocytes
| - Ca2+ store/sensor [2] - Ca2+-dependent interaction with cytoskeleton [27, 29, 32]: ↑migration, ↑degranulation, ↑phagocytosis - S100A9 ↓microtubule polymerization [32] |
