Fig. 4
TREG suppression assay. a Representative depiction of CFSE stainings of allogenic effector T cells (TEFF) incubated without regulatory T cells (TREG) (left chart), with TREG from an H1/H1 carrier (middle chart) and TREG from an H1/H2 carrier (right chart). Percentages of proliferated TEFF cells are indicated. b Proliferation rate of TEFF (%) coincubated with TREG from H1/H1 carriers (black bars, n = 2) and from H1/H2 carriers (gray bars, n = 2) in different TEFF/TREG ratios. Median and range are indicated. The dotted line indicates proliferation rate of TEFF incubated without TREG. p value for the effect of TEFF/TREG titration considering both haplotypes (Friedman test) is indicated as ** for p = 0.005