Morphogen | Function | Expression site | Receptor in target | References |
---|---|---|---|---|
Wnt9b | Induction of nephrogenesis, mesenchymal-to-epithelial transition (MET) | CD ampulla | FZD (Frizzled)/LRP receptor-related protein in mesenchyme | [97] |
BMP4 | Prevention of ectopic branching of CD tubule | Mesenchyme | Activin-like kinase 3/6 (Alk)/type II receptor in CD ampulla | [131] |
BMP7 | Branching of CD ampulla, competence and receptivity in mesenchyme | Mesenchyme | Activin-like kinase 3/6 (Alk)/type II receptor in CD ampulla in mesenchyme | |
GDNF | Elongation of CD tubule, branching of CD ampulla, site-specific cell proliferation | Mesenchyme | Receptor tyrosine-protein kinase (Ret)/GDNF f-mily receptor Alpha 1 (GFRα1) in CD ampulla | [80] |
Wnt5a | Clear position of mesenchyme, induction of nephrogenesis | CD ampulla | FZD (Frizzled)/LRP receptor-related protein In mesenchyme | [132] |
Wnt4 | Induction of nephrogenesis, mesenchymal-to-epithelial transition (MET) | Condensing mesenchyme Pretubular aggregate | FZD (Frizzled)/LRP receptor-related protein in mesenchyme | |
Fgf8 | Transition of induced mesenchyme into pretubular aggregate and renal vesicle | Mesenchyme Renal vesicle | Fibroblast growth factor receptor 1 and 2 (Fgfr1/2) in mesenchyme |