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Molecular and Cellular Pediatrics
Fig. 5 | Molecular and Cellular Pediatrics

Fig. 5

From: Concepts for a therapeutic prolongation of nephrogenesis in preterm and low-birth-weight babies must correspond to structural-functional properties in the nephrogenic zone

Fig. 5

Schematic illustration informs about the incomplete vascular supply of the nephrogenic zone (NZ) in a neonatal rabbit kidney. Label by antibody EC1 [58] depicts that endothelial cells arise from cortical radiate arteries (arrow) lining in parallel to the collecting duct (CD) tubules. Endothelial cells (arrow heads) migrate to the lateral aspect of an ureteric bud derived CD ampulla (A) and to the lower cleft of a S-shaped body (S). In addition, cells of the tunica muscularis within the organ capsule (C) form intracellular and extracellular tunnels (asterisks) for production of interstitial fluid [10]. It is obvious that the area of the niche including the tip of a CD ampulla with epithelial (EPI) cells and neighboring mesenchymal cells (MES) is avascular. PA pretubular aggregate, RV renal vesicle

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