Fig. 3From: Role of second-hand smoke (SHS)-induced proteostasis/autophagy impairment in pediatric lung diseasesSchema showing novel mechanism for SHS-induced pediatric lung dysfunction. Exposure to SHS during early lung development (neonates/pediatric population) may potentiate initiation of chronic lung disease via oxidative stress mediated proteostasis/autophagy impairment and/or induction of HIF-1α levels. Therapeutic intervention using proteostasis/autophagy inducing drugs may mitigate the SHS exposure-mediated pathogenic changes initiating pediatric lung diseases such as bronchopulmonary dysplasia (BPD) or adult COPD-emphysema-like childhood conditionBack to article page