TY - JOUR AU - Patel, Neel AU - Trumph, Christopher D. AU - Bodas, Manish AU - Vij, Neeraj PY - 2017 DA - 2017/02/02 TI - Role of second-hand smoke (SHS)-induced proteostasis/autophagy impairment in pediatric lung diseases JO - Molecular and Cellular Pediatrics SP - 3 VL - 4 IS - 1 AB - Exposure to second-hand tobacco smoke (SHS) is one of the prime risk factors for chronic lung disease development. Smoking during pregnancy may lead to birth defects in the newborn that include pulmonary dysfunction, increased susceptibility to opportunistic pathogens, or initiation of childhood respiratory manifestations such as bronchopulmonary dysplasia (BPD). Moreover, exposure to SHS in early childhood can have negative impact on lung health, although the exact mechanisms are unclear. Autophagy is a crucial proteostatic mechanism modulated by cigarette smoke (CS) in adult lungs. Here, we sought to investigate whether SHS exposure impairs autophagy in pediatric lungs. SN - 2194-7791 UR - https://doi.org/10.1186/s40348-017-0069-7 DO - 10.1186/s40348-017-0069-7 ID - Patel2017 ER -