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Table 2 Indirect targets of NE-dependent regulation and cognate signaling pathways

From: Neutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway disease

Regulatory target

Modulation by NE

Signaling pathway

β-defensin 2 [193]

Activation

Unknown

Cathepsin B [194]

Activation

TLR4/IRAK

CFTR [97]

Inhibition

Calpain

P. aeruginosa flagellin [81]

Inhibition

Unknown

IL-12 p40 [195]

Activation

PAR-2/EGFR/TLR4

IL-8 [83, 192, 196, 197]

Activation

TLRs/MyD88/IRAK/TRAF-6

MHC I [198]

Activation

Unknown

MMP-2 [194]

Activation

TLR4/IRAK

MUC5AC [199, 200]

Activation

EGFR

  1. EGFR epidermal growth factor receptor, ERK extracellular-regulated kinase, IRAK-1 IL-1 receptor associated kinase-1, MHC I major histocompatibility complex I, PAR-2 protease-activated receptor-2, TLR4 Toll-like receptor 4