Table 1 Leukocyte adhesion molecules
Endothelial adhesion molecule | Leukocyte ligand | Endothelial ligand | Functions |
|---|---|---|---|
E-selectin | PSGL-1, CD44, ESL-1 | None | Capturing, rolling, integrin activation |
P-selectin | PSGL-1 | None | Capturing, rolling, integrin activation |
ICAM-1 | LFA-1, Mac-1 | None | Rolling, adhesion, crawling |
VCAM-1 | VLA4 | None | Rolling, adhesion, crawling |
RAGE | Mac-1 | None | Adhesion, crawling, transmigration |
ICAM-2 | LFA-1, Mac-1 | None | Crawling, initiating diapedesis |
JAM-A | LFA-1 | JAM-A | Leukocyte diapedesis |
JAM-B | VLA-4 | JAM-B, JAM-C | Prevention of reverse TEM |
JAM-C | Mac-1 | JAM-C, JAM-B | Prevention of reverse TEM |
ESAM | Unknown | ESAM | Diapedesis |
PECAM-1 | PECAM-1 | PECAM-1 | Promoting TEM |
CD99 | CD99 | CD99 | Promoting TEM |
CD99L2 | CD99L2 | CD99L2 | Promoting TEM |
VE-cadherin | None | VE-cadherin | Preventing diapedesis |