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Table 1 Overview of cells relevant for alveologenesis

From: Alveologenesis: key cellular players and fibroblast growth factor 10 signaling

Name of cell Name of progenitor cell Localization of cell Function of cell for alveologenesis Interaction with other cells
Alveolar epithelial cell type I (AEC I) Bipotent progenitor (Sftpc+, Pdpn+) [1] Epithelium Providing the majority of alveolar surface area AEC II (during regeneration) [16]
Alveolar epithelial cell type II (AEC II) Bipotent progenitor (Sftpc+, Pdpn+) [1] Epithelium, close proximity to lipofibroblast Surfactant production, transdifferentiation to AEC I after lung injury [16] Formation and maintenance of Lipofibroblast via Pthrp (parathyroid hormone-related protein)/Pparg (peroxisome proliferator-activated receptor gamma) signaling pathway [35, 37]
Alveolar myofibroblast Alveolar myofibroblast progenitor; Pdgfra + LIF (to be validated) [25] Mesenchyme, Tip of growing secondary septae Deposition of Elastin in the apex of secondary septae and secondary septae formation [30, 55] Not known
Lipofibroblast Fgf10+ mesenchymal cell [32, 33] Mesenchyme, close proximity to AEC II Secretion of triglycerides and leptin for AEC II [37] postnatal niche for AEC II [34] AEC II [35, 37], epithelium (Pdgfa) [31]
Endothelial cell Endothelial progenitor cell (hemangioblasts) Subepithelial mesenchyme (SEM) Angio-/vasculogenesis important for alveologenesis [47] Epithelium [43, 45]