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Molecular and Cellular Pediatrics
Figure 7 | Molecular and Cellular Pediatrics

Figure 7

From: Propofol administration to the maternal-fetal unit improved fetal EEG and influenced cerebral apoptotic pathway in preterm lambs suffering from severe asphyxia

Figure 7

Activation and inhibition of apoptotic pathways in the fetal ovine brain. Propofol reduced expression of NMDA receptors and occurrence of reactive oxygen species (ROS). In addition, Propofol treatment resulted in activation of pSTAT-3 which inhibited release of cytochrome c from the mitochondria. Consequently, activation of caspases-9 and -3 was reduced. NMDA-R, N-methyl-d-aspartate-receptor; pSTAT-3, phosphorylated signal transducer and activator of transcription-3; Bcl-xL, B-cell lymphoma-extra large; caspase, cysteinyl aspartate-specific protease.

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