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Figure 5 | Molecular and Cellular Pediatrics

Figure 5

From: Propofol administration to the maternal-fetal unit improved fetal EEG and influenced cerebral apoptotic pathway in preterm lambs suffering from severe asphyxia

Figure 5

Western blot in frontal cortex of fetal brain. Western blot for (A) NMDA receptors, (B) pSTAT-3, (C) Bcl-xL, (D) cytochrome c, (E) cleaved caspase-9, and (F) cleaved caspase-3 in frontal cortex of fetal brain normalized to β-actin. Levels of the gestational age control group were set to 1 in all panels. Depicted are mean and SEM. Significant differences (p < 0.05) compared to gestational age control groups are marked by (*). Significant differences (p < 0.05) between asphyxiated and corresponding non-asphyxiated drug control group are marked by § and significant differences between asphyxiated propofol and asphyxiated isoflurane treated lambs are marked by ‡. NMDA-R, N-methyl-d-aspartate-receptor; GA, gestational age; pSTAT-3, phosphorylated signal transducer and activator of transcription-3; Bcl-xL, B-cell lymphoma-extra large; caspase, cysteinyl aspartate-specific protease.

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