Table 2 Biomarker studies of human blood serum and plasma

Abd-El-Fattah et al. 2013 [23]

Custom array for unspecified number of miRNAs (single samples)

29 TB, 37 healthy controls (no definition)

miR-182 miR-197

miR-197

Qi et al. 2012 [22]

Array for 667 miRNAs (pooled for study groups)

30 TB, 65 healthy controls (negative chest X-ray and IGRA, free from clinical symptoms of infection)

miR-361-5p miR-889 miR-576-3p

miR-25 miR-590-5p miR-885-5p

Miotto et al. 2013 [24]

Array for 671 miRNAs (pools of 10 individuals)

154 pulmonary TB, 105 healthy controls (negative IGRA or TST, no risk-factors for LTBI, no clinically significant condition) over 2 cohorts

miR-148a miR-16 miR-192 miR-193a-5p miR-25 miR-365 miR-451 miR-532-5p miR-590-5p miR-660 miR-885-5p miR-223^a miR-30e

let-7e miR-146

miR-365

Fu et al. 2011 [20]

Array for 1,223 miRNAs (pooled for study groups)

75 TB, 52 healthy controls (defined as `free of active and latent TB')

miR-93^a

miR-29a

miR-3125

miR-483-5p miR-22

Zhang et al. 2013 [25]

Deep sequencing (20 individual samples for each group)

128 pulmonary TB, 108 healthy controls (no definition)

miR-378 miR-483-5p miR-22 miR-29c

miR-101 miR-320b