Table 1 Biomarker studies of human blood and enriched immune cell populations

Wang et al. 2011 [13]

miRNA, array (955 miRNAs)

6 TB patients, 6 LTBIs

6 between TB and LTBI miR-21^a miR-223 miR-302a miR-424 miR-451 miR-486-5p

miR-130b^a

miR-424

Spinelli et al. 2013 [14]

Candidate approach (6 miRNAs)

24 TB patients, 20 TSTneg

miR-424

miR-146a

Wang et al. 2011 [13]

miRNA, array (955 miRNAs)

6 TB patients, 3 TSTneg

4 miRNAs miR-144 miR-365 miR-133a miR-424

3 miRNAs miR-500 miR-661 miR-892b

miR-144

Liu et al. 2011 [16]

miRNA array

3 TB patients, 3 controls (not further defined)

28 miRNA nv miR-144^a

2 miRNAs nv

Kleinsteuber et al. 2013 [18]

Candidate approach (29 miRNAs) enriched blood T cells

7 TB patients, 6 LTBIs, 3 TSTneg

No

4 miRNAs miR-21 miR-26a miR-29a miR-142-3p

Fu et al. 2013 [17]

miRNA array (≈1,223 miRNAs) enriched blood T cells pooled from 4 donors

4 TB patients, 4 LTBIs, 4 TSTneg

6 miRNAs^b miR-340-5p miR-451a miR-32-5p miR-27a-3p miR-29a miR-29b

4 miRNAs^b miR-136-5p miR-4292 miR-H8^a miR-1915-3p miR-4258

miR-451 (Wang et al. 2011)