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Table 1 Biomarker studies of human blood and enriched immune cell populations

From: Are microRNAs suitable biomarkers of immunity to tuberculosis?

Study Study type Study group sizes Upregulated Downregulated Overlap of differentially expressed miRNAs
Wang et al. 2011 [13] miRNA, array (955 miRNAs) 6 TB patients, 6 LTBIs 6 between TB and LTBI miR-21a miR-223 miR-302a miR-424 miR-451 miR-486-5p miR-130ba miR-424
Spinelli et al. 2013 [14] Candidate approach (6 miRNAs) 24 TB patients, 20 TSTneg miR-424 miR-146a
Wang et al. 2011 [13] miRNA, array (955 miRNAs) 6 TB patients, 3 TSTneg 4 miRNAs miR-144 miR-365 miR-133a miR-424 3 miRNAs miR-500 miR-661 miR-892b miR-144
Liu et al. 2011 [16] miRNA array 3 TB patients, 3 controls (not further defined) 28 miRNA nv miR-144a 2 miRNAs nv
Kleinsteuber et al. 2013 [18] Candidate approach (29 miRNAs) enriched blood T cells 7 TB patients, 6 LTBIs, 3 TSTneg No 4 miRNAs miR-21 miR-26a miR-29a miR-142-3p  
Fu et al. 2013 [17] miRNA array (≈1,223 miRNAs) enriched blood T cells pooled from 4 donors 4 TB patients, 4 LTBIs, 4 TSTneg 6 miRNAsb miR-340-5p miR-451a miR-32-5p miR-27a-3p miR-29a miR-29b 4 miRNAsb miR-136-5p miR-4292 miR-H8a miR-1915-3p miR-4258 miR-451 (Wang et al. 2011)
  1. nv not verified by rtPCR, TB tuberculosis, LTBI latently M. tuberculosis-infected, TSTneg tuberkulin skin test negative individuals, miRNAs microRNAs.
  2. aIndicates a mature miRNA species found at low levels from the opposite arm of a pre-miRNA hairpin.
  3. bWithin the miRNA candidate gene group differentially expressed as compared to TSTneg.