Matrix metalloproteinases and epileptogenesis

Molecular and Cellular Pediatrics

Table 1 MMP substrates in synapses

Target	MMP	Receptors/binding partners	Synaptic effect
ECM proteins
Laminin	MMP2,3,7,9,11,12,19,25	Integrins	Synapse formation and remodeling, NMDA-R activity, hippocampal LTP
Brevican	MMP1,2,3,7,8,10,13	Tenascin-R, hyaluronan	Hippocampal LTP
Tenascin-R	MMP14,15	Brevican	Synapse formation, hippocampal LTP, learning and memory
Tenascin-R	MMP1,2,3,7,8,13	Brevican	Synapse formation, hippocampal LTP, learning and memory
Growth factors
TNF-α	MMP14,15,16	TNFR1, TNFR2	AMPA receptor trafficking, synaptic scaling
TNF-α	MMP1,2,3,7,8,9,12,13	TNFR1, TNFR2	AMPA receptor trafficking, synaptic scaling
BDNF	MMP2,3,7,9	trkB, p75	Hippocampal LTP, learning and memory
ProBDNF	MMP9	trkB, p75	Hippocampal LTP, learning and memory
ProNGF	MMP7	p75	Cell survival
Membrane proteins
N-Cadherin	MMP24	N-Cadherin, catenin	Synapse formation and stability, LTP
β-Dystroglycan	MMPs	α-Dystroglycan, dystrophin	Hippocampal LTP
Ephrin-B2	MMPs	EphB receptors	Synapse formation and stability, hippocampal LTP, learning and memory