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Table 1 MMP substrates in synapses

From: Matrix metalloproteinases and epileptogenesis

Target MMP Receptors/binding partners Synaptic effect
ECM proteins    
Laminin MMP2,3,7,9,11,12,19,25 Integrins Synapse formation and remodeling, NMDA-R activity, hippocampal LTP
Brevican MMP1,2,3,7,8,10,13 Tenascin-R, hyaluronan Hippocampal LTP
Tenascin-R MMP14,15 Brevican Synapse formation, hippocampal LTP, learning and memory
MMP1,2,3,7,8,13
Growth factors    
TNF-α MMP14,15,16 TNFR1, TNFR2 AMPA receptor trafficking, synaptic scaling
MMP1,2,3,7,8,9,12,13
BDNF MMP2,3,7,9 trkB, p75 Hippocampal LTP, learning and memory
ProBDNF MMP9
ProNGF MMP7 p75 Cell survival
Membrane proteins    
N-Cadherin MMP24 N-Cadherin, catenin Synapse formation and stability, LTP
β-Dystroglycan MMPs α-Dystroglycan, dystrophin Hippocampal LTP
Ephrin-B2 MMPs EphB receptors Synapse formation and stability, hippocampal LTP, learning and memory
  1. Adapted and modified from Ethel and Ethel [5].