The role of regulatory B cells in immune regulation and childhood allergic asthma

Molecular and Cellular Pediatrics

Table 1 Different subsets and functions of human Bregs

Name	Phenotype	Functions
B10 cells	CD27⁺CD24^hi	Regulate cytokine production by monocytes [60]
Immature transitional B cells	CD19⁺CD24^hiCD38^hi	Suppress T_H1 and T_H17 cell differentiation [15, 61] Induce conversion of Tregs [61] Regulate T cell immunity in CHB [62]
B_R1 cells	CD19⁺CD25⁺CD71⁺CD73⁻	Suppress CD4⁺ T cell proliferation Production of IgG₄ antibodies [63]
Plasmablasts	CD19⁺CD27^intCD38⁺	Inhibit DC functions to generate autoreactive T cells [16]
Plasma cells	IgA⁺PD-L1⁺IL-10⁺	Suppress anti-tumour immunity [64]
GrB⁺ B cells	CD19⁺CD38⁺CD1d⁺IgM⁺CD147⁺	Suppress T cell proliferation by degradation of TCR [65]
CD9⁺ B cells	CD19⁺CD9⁺	Induction of T cell apoptosis [66]
CD5⁺CD1d⁺ B cells	CD19⁺CD5⁺CD1d^hi	Suppress T_H17 response [67] and IL-22 production [68]