Fig. 1

Elevated S100A12 levels in FMF patients despite inactive disease. Clinically inactive (CRP negative) FMF patients from our outpatient clinic (Table 1) were measured routinely for S100A8/A9 (A) and neutrophil count (B), showing significantly elevated levels compared to healthy controls. In a homogeneous FMF cohort (Table 1) from the AID-Net biorepository, S100A8/A9 (C) and S100A12 (D) levels were measured in homozygous and heterozygous FMF patients with the M694V genotype indicating a gene-dose effect with higher levels in homozygous patients (*p < 0.05, ***p < 0.001)