From: Bronchopulmonary dysplasia - an overview about pathophysiologic concepts
Study | Species | Mode of injury | Main finding |
---|---|---|---|
Alvira et al. [27] | Mouse (PN 5, 16 weeks) | Intraperitoneal injection of lipopolysaccharides (LPS) | Persistent NF-kB activation in the fetal lung leads to reduced inflammation and apoptosis 24 h after LPS exposure in contrast to adult animals |
Asikainen et al. [23] | Baboons (E 125) | MV at room air or with oxygen supplementation as calculated by oxygenation index | Enhancement of angiogenesis by activation of HIF improves lung growth and function |
Blackwell et al. [14] | Mouse (E 15) | LPS in isolated macrophages | Macrophage depletion or targeted inactivation of the NF-κB signaling pathway protects airway branching from adverse LPS effects |
Bland et al. [15] | Mouse (PN 5 to 7) | MV at room air or with 40% oxygen | MV results in increased elastase activity, reduced abundance of proteins regulating elastic fiber assembly and scattered deposition of elastic fibres in the lung |
Compernolle et al. [24] | Mouse (E 18.5) | Transgenic mouse model (knock out of HIF 2α) | Intrauterine delivery or postnatal intratracheal instillation of VEGF stimulates surfactant synthesis and reduces respiratory distress |
Iosef et al. [16] | Mouse (PN 6) | Intraperitoneal injection of blocker of NF-κB (BAY 11-7082) | NF-κB promotes physiological angiogenesis and alveolarization in the developing lung |
Wallace et al. [12] | Lambs (E 125 and 132) | MV at room air | Increase in pulmonary pro-inflammatory cytokines transcription |